[The pathogenetic problems of gastric and duodenal peptic ulcer]. / Nekotorye voprosy patogeneza iazvennoi bolezni zheludka i dvenadtsatiperstnoi kishki.

Studies into the content of nonspecific defense factors, secretory and serum immunoglobulins in blood and biological fluids (saliva, gastric juice, duodenal contents) in patients suffering from peptic ulcer have demonstrated significant changes in local and general immunity. Exacerbation of the disease was marked by a decrease of the titer of complement, C3-component of complement, and lysozyme level. At the same time there was an increase of the concentration of secretory immunoglobulins and immunoglobulins in blood serum and external secretions. The data obtained attest to the tension of humoral immunity and nonspecific defense in peptic ulcer patients, giving rise to the consideration of the changes in the humoral component as one of potential mechanisms by which ulcer is formed.

[Changes in secretory immunoglobulin A level in the blood serum of patients with peptic ulcer]. / Izmenenie soderzhaniia sekretornykh immunoglobulinov A v syvorotke krovi u bol'nykh iazvennoi bolezn'iu.

Serum levels of secretory IgA were measured in 66 patients with aggravation of peptic ulcer versus 52 healthy subjects. IgA concentrations in the patients were found elevated, the rise being dependent on the ulcer site, standing and severity of course. Treatment-induced decline of the ulcer exacerbation was accompanied by a fall in IgA levels. It is hold that serum IgA can serve a marker of gastroduodenal ulcer exacerbation.

[The status of general and local humoral immunity in patients with peptic ulcer and chronic gastroduodenitis]. / Sostoianie obshchego i lokal'nogo gumoral'nogo immuniteta u bol'nykh iazvennoi bolezn'iu i khronicheskim gastroduodenitom.

The content of secretory immunoglobulins A and serum immunoglobulins A, M, G, D in the blood serum and biological. fluids (saliva, gastric juice and duodenal contents) was examined in 108 patients with gastric and duodenal ulcer and in 68 patients with chronic gastroduodenitis. The obtained data evidence tense states of the general and local humoral immunity in all patients with gastric and duodenal ulcer and chronic gastroduodenitis. Monotypical changes in patients with diseases of the gastroduodenal zone, apparently, reflect the participation of the immunological component of the ulcerogenic situation already at the stage of preulcer condition.

[Functional state of the hypothalamo-hypophyseal-gonadal system in patients with duodenal ulcer]. / Funktsional'noe sostoianie gipotalamo-gipofizarno-gonadnoi sistemy u bol'nykh iazvennoi bolezn'iu dvenadsatiperstnoi kishki.

The paper considers common phase-specific trends in hypothalamic-hypophyseal-gonadal function observed in duodenal ulcer. Progesterone and estradiol levels as well as testosterone/estradiol relationship correlated with frequency of duodenal ulcer recurrences.

[General and local humoral immunity in patients with peptic ulcer]. / Obshchii i mestnyi gumoral'nyi immunitet u bol'nykh iazvennoi bolezn'iu.

Systemic and local humoral immunity and nonspecific defense factors were investigated in 88 patients with duodenal peptic ulcers and 18 patients with gastric ulcers. In acute conditions, nonspecific defence was depressed and blood IgG level was increased in peptic ulcer patients. An increase in complement titre, C3 and lysozyme, and a decrease in IgG were recorded after treatment, although normal levels were never attained. Salivary, gastric-juice and duodenal-content secretory IgA levels were characteristically increased during acute phases of peptic ulcer; salivary IgA declined after treatment. The disturbance of nonspecific defence, systemic and local humoral immunity, demonstrated in patients with peptic ulcers, may be regarded as a possible ulcerogenic mechanism.