1.
Biochem Soc Trans
; 22(1): 18S, 1994 Feb.
Article
in English
| MEDLINE
| ID: mdl-7515829
Subject(s)
Bone Neoplasms/enzymology , Bone Neoplasms/pathology , Endopeptidases/metabolism , Neoplasm Invasiveness , Osteosarcoma/enzymology , Osteosarcoma/pathology , Aminocaproic Acid/pharmacology , Aprotinin/pharmacology , Biocompatible Materials , Cell Line , Collagen , Drug Combinations , Humans , Laminin , Proteoglycans , Tumor Cells, Cultured
2.
Am J Surg
; 162(6): 620-2; discussion 622-3, 1991 Dec.
Article
in English
| MEDLINE
| ID: mdl-1670238
ABSTRACT
This study compared the healing of midline fascial incisions made with either scalpel or electrocautery and inoculated with Escherichia coli in 57 Sprague-Dawley rats. At 7 days, tensile strength was significantly less when incisions were made with electrocautery than with a scalpel. Additionally, would strength was inversely related to the concentration of the inoculum of E coli. The use of electrocautery was also associated with more frequent bacteremia at 48 hours and higher mortality at 7 days. Our results suggest that the technique used to incise the abdominal fascia influences subsequent wound healing, particularly in contaminated wounds.