Subject(s)
Neurilemmoma/diagnosis , Aged, 80 and over , Dermoscopy/methods , Humans , Male , Neurilemmoma/diagnostic imagingSubject(s)
Vulvar Lichen Sclerosus/immunology , Aged, 80 and over , Eosinophilia/etiology , Female , HumansSubject(s)
Acute Generalized Exanthematous Pustulosis/pathology , Skin/pathology , Stevens-Johnson Syndrome/pathology , Acute Generalized Exanthematous Pustulosis/chemically induced , Acute Generalized Exanthematous Pustulosis/drug therapy , Administration, Oral , Adult , Anticonvulsants/adverse effects , Biopsy , Drug Administration Schedule , Glucocorticoids/administration & dosage , Humans , Lamotrigine , Male , Predictive Value of Tests , Prednisolone/administration & dosage , Skin/drug effects , Stevens-Johnson Syndrome/drug therapy , Stevens-Johnson Syndrome/etiology , Time Factors , Treatment Outcome , Triazines/adverse effectsSubject(s)
Fabry Disease/pathology , Hemangioma/ultrastructure , Microscopy, Electron , Skin Neoplasms/ultrastructure , Adult , Early Diagnosis , Enzyme Replacement Therapy , Fabry Disease/drug therapy , Humans , Isoenzymes/therapeutic use , Male , Predictive Value of Tests , alpha-Galactosidase/therapeutic useSubject(s)
GTP Phosphohydrolases/genetics , Melanoma/pathology , Membrane Proteins/genetics , Nevus, Pigmented/pathology , Skin Neoplasms/pathology , Adult , Cell Transformation, Neoplastic/genetics , Humans , Male , Melanoma/genetics , Nevus, Pigmented/congenital , Nevus, Pigmented/genetics , Skin Neoplasms/geneticsSubject(s)
Foot Diseases/pathology , Nevus, Pigmented/pathology , Skin Neoplasms/pathology , Female , Humans , Middle AgedSubject(s)
Lymphomatoid Papulosis/therapy , Neoplasm Recurrence, Local/therapy , Skin Neoplasms/therapy , Adult , Humans , Ichthyosis/complications , Lymphatic Metastasis , Lymphomatoid Papulosis/complications , Lymphomatoid Papulosis/pathology , Male , Neoplasm Recurrence, Local/pathology , Skin Neoplasms/complications , Skin Neoplasms/pathology , ThighSubject(s)
Foot/pathology , Melanoma/pathology , Skin Neoplasms/pathology , Dermoscopy/methods , Female , Humans , Middle Aged , Nevus, Pigmented/pathology , PressureABSTRACT
We present two cases of spindle cell squamous cell carcinoma, which were derived from solar keratosis and burn scar in two elderly Japanese patients, respectively. The tumors involved the whole dermis and subcutis in connection with the overlying epidermis. They were composed mainly of anaplastic spindle cells partially forming storiform patterns. The tumor cells were diffusely positive for vimentin and cytokeratin 8/18 (clone CAM5.2, simple epithelial cytokeratin), but negative for cytokeratin 1/5/10/14 (clone 34ßE12, stratified epithelial cytokeratin). Ultrastructural analysis of a patient demonstrated desmosomes and tonofilaments in the tumor cells. Although spindle cell squamous cell carcinoma is usually positive for vimentin, detailed cytokeratin profile is controversial. The present cases revealed immunohistochemistry not expressing stratified but simple epithelial cytokeratin and vimentin. We should be reminded of the efficacy of simple epithelial cytokeratin immunoreactivity in spindle cell squamous cell carcinoma.
Subject(s)
Carcinoma, Squamous Cell/metabolism , Keratins/metabolism , Skin Neoplasms/metabolism , Vimentin/metabolism , Aged , Female , Humans , Immunohistochemistry , MaleSubject(s)
Facial Neoplasms/genetics , Nevus, Epithelioid and Spindle Cell/genetics , Proto-Oncogene Proteins p21(ras)/genetics , Skin Neoplasms/genetics , Facial Neoplasms/pathology , Facial Neoplasms/surgery , Genetic Testing , Humans , Male , Middle Aged , Mutation , Nevus, Epithelioid and Spindle Cell/pathology , Nevus, Epithelioid and Spindle Cell/surgery , Skin Neoplasms/pathology , Skin Neoplasms/surgeryABSTRACT
Erythema multiforme is a relatively common skin disorder; the most common cause is herpes simplex infection, but topical sensitivities reportedly also provoke this reaction. We report here a case that progressed to toxic epidermal necrolysis due to contact with ultraviolet (UV)-cured inks. The diagnosis was confirmed by patch tests to acrylates in the UV-cured inks, histopathological studies of the lesions, and positive patch test to 1,6-hexanediol diacrylate.
Subject(s)
Dermatitis, Occupational/etiology , Ink , Occupational Exposure/adverse effects , Stevens-Johnson Syndrome/etiology , Acrylates/adverse effects , Adult , Dermatitis, Allergic Contact/etiology , Dermatitis, Allergic Contact/pathology , Dermatitis, Occupational/pathology , Female , Glucocorticoids/therapeutic use , Humans , Prednisolone/therapeutic use , Stevens-Johnson Syndrome/drug therapy , Stevens-Johnson Syndrome/pathologyABSTRACT
PURPOSE: To investigate the risk factors associated with work-related allergy-like symptoms in medical doctors. METHODS: Self-administered questionnaire survey and CAP test were conducted among medical school students in the 4th grade of their 6-year medical course in 1993-1996 and 1999-2001. Follow-up questionnaires were sent in 2004 to the graduates. These questionnaires enquired into personal and family history of allergic diseases, lifestyle, history of allergy-like symptoms including work-relatedness and occupational history as medical doctors. Relationships between allergy-like symptoms and relevant factors were evaluated by multivariate logistic regression analysis. RESULTS: Of 261 respondents at the follow-up survey, 139 (53.3%) and 54 (20.7%) had a history of any allergy-like symptoms and any work-related allergy-like symptoms, respectively. Female gender and family history of allergic diseases were significantly associated with any allergy-like symptoms. Personal history of allergic disease, exposure to domestic animals, eczema caused by rubber gloves, metallic accessories, or cosmetics during schooling days, and membership of the surgical profession were significant risk factors for work-related allergy-like symptoms. On the contrary, to work-related allergy-like symptoms, gender, age, and smoking status were not significantly related, and consumption of prepared foods was inversely related. CONCLUSIONS: Personal history of atopy and eczema induced by common goods and the history of keeping domestic animals may be predictors of work-related allergy-like symptoms in doctors. After graduation from medical school, physicians start with exposure to various allergens and irritants at work, which relate to work-related allergy-like symptoms, especially for surgeons.
Subject(s)
Eczema/etiology , Hypersensitivity/etiology , Occupational Diseases/etiology , Occupational Exposure/statistics & numerical data , Adult , Animals , Animals, Domestic , Female , Follow-Up Studies , Humans , Logistic Models , Male , Physicians , Risk Factors , Skin Tests , Specialties, Surgical , Students, Medical , Surveys and Questionnaires , Young AdultABSTRACT
63-year-old man presented with a dome-shaped, black nodule on his right forehead, where hairs were preserved. The black surface tone measured 7 mm in diameter and spread irregularly from the periphery of the nodule. He had been conscious of the preceding, black macule for approximately 50 years. A snap shot of the patient in adolescence showed a tiny, black macule, which was a few millimeters in diameter. Histological examination demonstrated irregular proliferation of melanoma cells from the epidermis to the dermis. Partially, there were well-circumscribed, oval nests composed of nevus cells in the acanthotic epidermis and follicles. Nevus cells were also seen in the dermal component, presenting a burnt-out appearance. In this case, the small final size, the preserved hairs and the snap shot suggested a preceding, acquired melanocytic nevus. Malignant melanoma could arise from acquired melanocytic nevus.
