Subject(s)
Cauda Equina/pathology , Neuroectodermal Tumors, Primitive, Peripheral/physiopathology , Neuroectodermal Tumors, Primitive, Peripheral/surgery , Neurosurgical Procedures/methods , Peripheral Nervous System Neoplasms/physiopathology , Peripheral Nervous System Neoplasms/surgery , Aged , Antigens, CD/metabolism , Cauda Equina/diagnostic imaging , Cauda Equina/surgery , Databases, Bibliographic , Humans , Magnetic Resonance Imaging , Male , Mucin-1/metabolism , Neuroectodermal Tumors, Primitive, Peripheral/diagnostic imaging , Peripheral Nervous System Neoplasms/diagnostic imaging , Prostate-Specific Antigen/metabolismABSTRACT
BACKGROUND: Treatment options for recurrent glioma of the brain include chemotherapy, radiotherapy, surgery, and palliation. Temozolomide appears to be effective in patients with recurrent high-grade gliomas. CASE DESCRIPTION: A middle-aged woman presented with a high-grade glioma of corpus callosum. The tumor, a grade 3 anaplastic oligodendroglioma, was excised, and chemoradiotherapy was administered. The patient presented with significant recurrence 5 years later. Repeat surgery and radiation were suggested but refused. She was given temozolomide and dexamethasone intermittently, and levetiracetam was continued. Magnetic resonance imaging performed at 10-month follow-up showed 90% remission. CONCLUSIONS: There are a few reports in the literature of similar response to temozolomide and levetiracetam. Similar reports give more hope in the treatment of recurrent high grade glioma.
