1.
Chem Biodivers
; 15(11): e1800277, 2018 Nov.
Article
in English
| MEDLINE
| ID: mdl-30187628
ABSTRACT
Novel 2,3-dihydrofuran derivatives were synthesized through a tandem Knoevenagel-Michael cyclization in good yield by reacting α-tosyloxy ketone, 5,5-dimethyl-1,3-cyclohexanedione, and various aldehydes in the presence of phthalazine in acetonitrile. These compounds were subjected to inâ vitro antibacterial screening against eight micro-organisms by using diffusion method and also inâ vitro cytotoxicity screening against four human cancerous cell lines by applying MTT assay. Some of the compounds showed impressive activities.