ABSTRACT
BACKGROUND: Distal duodenal and duodenojejunal flexure tumors are rare. They present late due to vague symptomatology and difficulties in establishing a diagnosis. Due to vague symptoms, these tumors would have had spread locally or metastasized to regional nodes or distant organs at presentation. Though the present standard is to achieve R0 resection for any tumor, it is quite difficult in these tumors because of their proximity to many important named vessels and viscera. Role of neoadjuvant and adjuvant therapy is not established yet. METHODS: Medical records of patients searched who were admitted and diagnosed to have duodenal tumors between January, 2011 and March, 2014. Patients with duodenal tumors arising from third or fourth part were analysed. Radiological, endoscopic findings were noted and compared with operative and histopathological report. RESULTS: Nine patients (seven males and two females) were found to have tumor in the third and fourth part of the duodenum. All had undergone laparotomy with curative intention in eight patients. R0 resection was feasible only in five (55%) patients. The most common histopathological type is adenocarcinoma in 66% patients. CONCLUSIONS: Segmental resection is feasible and may be curative in most of the patients with duodenojejunal flexure tumors, without the need for vascular resections and reconstructions. Adenocarcinomas are the most common variant. Lymph node involvement and microvascular invasion indicates poor prognosis.
ABSTRACT
Botryoid odontogenic cyst (BOC) is considered to be a polycystic variant of the lateral periodontal cyst (LPC) as the specimen resembled a cluster of grapes. It is a non-inflammatory odontogenic cyst. The BOCs can be unicystic or multicystic. These cysts have potential to extend in the bone and become multilocular and they have a high recurrence rate. Till now, only 73 cases of BOC have been reported. The pathogenesis of BOC is still debatable. We review different pathogenesis proposed for BOC and discuss a rare case of BOC developing from lining of an abnormally large LPC which showed aggressive behaviour in terms of growth and size.
ABSTRACT
We report a rare case of osteoglophonic dysplasia affecting father and daughter. Osteoglophonic dysplasia is a very rare skeletal dysplasia with craniosynostosis, multiple radiolucencies of bone and clinical anodontia. It is an autosomal dominant disorder characterised by short stature. The affected children have normal intelligence. Close association with missense mutation of fibroblast growth factor receptor-1 has been reported. Life expectancy depends on the degree of cranial malformation. In previous reports, bone defects usually resolved by adulthood, but multiple tooth impaction may cause aesthetic and masticatory problems. Cytogenetic studies and routine laboratory tests were all within normal limits.
