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1.
J Assoc Physicians India ; 72(7): 25-28, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38990583

ABSTRACT

BACKGROUND: Recent research has shown that low serum levels of magnesium are often linked to both microvascular and macrovascular complications in individuals with diabetes mellitus. Hence, monitoring of serum magnesium levels is needed in diabetic patients. Furthermore, the addition of magnesium through supplementation may present a novel therapeutic strategy for mitigating vascular complications in individuals with diabetes. OBJECTIVES: To assess the prevalence of hypomagnesemia in type 2 diabetes mellitus patients and to assess the association between hypomagnesemia and microvascular complications of diabetes mellitus in a tertiary care hospital in North Kerala. MATERIALS AND METHODS: An analytical cross-sectional study was conducted at a tertiary care hospital involving 230 diabetic patients receiving outpatient and inpatient care in the Department of Internal Medicine at Government Medical College, Kozhikode, Kerala. The study took place from January 2018 to December 2018, during which serum magnesium levels were assessed and analyzed in relation to the patients' microvascular complications and glycemic control. RESULTS: We observed that 19.13% of the participants had hypomagnesemia. This condition was found to be more common among older individuals with diabetes, as indicated by a p-value of 0.022. However, there were no significant differences in serum magnesium levels based on gender (p-value 0.18), body mass index (BMI) (p-value 0.223), or the duration of diabetes (p-value 0.36). The prevalence of diabetic retinopathy, diabetic neuropathy, and diabetic nephropathy was higher in diabetics with hypomagnesemia than their counterparts with normal magnesium, with a p-value of 0.001, 0.001, and 0.001, respectively. There was a significant negative correlation obtained between serum magnesium and glycated hemoglobin (HbA1C) values (Pearson coefficient = -0.240 and p-value = <0.01) and fasting blood sugar (FBS) values (Pearson coefficient = -0.265 and p-value = <0.01). CONCLUSION: Hypomagnesemia is negatively correlated with HbA1C and FBS but not related to duration of diabetes and gender. The prevalence of microvascular complications was higher among the diabetics with hypomagnesemia.


Subject(s)
Diabetes Mellitus, Type 2 , Magnesium , Humans , Diabetes Mellitus, Type 2/complications , Diabetes Mellitus, Type 2/blood , Diabetes Mellitus, Type 2/epidemiology , Male , Female , Cross-Sectional Studies , Middle Aged , Magnesium/blood , Prevalence , Magnesium Deficiency/epidemiology , Magnesium Deficiency/blood , Magnesium Deficiency/complications , Aged , India/epidemiology , Adult , Diabetic Angiopathies/epidemiology , Diabetic Angiopathies/etiology , Diabetic Angiopathies/blood , Glycated Hemoglobin/analysis
3.
Emerg Infect Dis ; 25(5): 1007-1010, 2019 05.
Article in English | MEDLINE | ID: mdl-31002050

ABSTRACT

We conducted a serosurvey of 155 healthcare workers and 124 household and community members who had close contact with 18 patients who had laboratory-confirmed Nipah virus infections in Kerala, India. We detected 3 subclinical infections; 2 persons had IgM and IgG and 1 only IgM against Nipah virus.


Subject(s)
Disease Outbreaks , Henipavirus Infections/epidemiology , Henipavirus Infections/transmission , Nipah Virus , Adolescent , Adult , Child , Female , Henipavirus Infections/virology , Humans , India/epidemiology , Male , Middle Aged , Nipah Virus/classification , Nipah Virus/genetics , Nipah Virus/immunology , Public Health Surveillance , Young Adult
4.
J Assoc Physicians India ; 66(10): 63-67, 2018 Oct.
Article in English | MEDLINE | ID: mdl-31317711

ABSTRACT

During May 2018 there occurred an outbreak in Kerala, which started in Soopikkada Village, Changarothu Grama Panchayath in Perambra Taluk, Kozhikode district, of a febrile illness with altered sensorium and ARDS. The diagnosis was made from the second case that it is the dreaded nipah infection. Following that 18 cases tested positive for nipah virus infection of which 2 survived. Also there were four deaths with similar clinical picture but which occurred before the virus was identified. They were considered as probable cases.


Subject(s)
Epidemics , Henipavirus Infections/epidemiology , Nipah Virus , Disease Outbreaks , Humans , India , Research Design
5.
Ann Indian Acad Neurol ; 15(2): 141-4, 2012 Apr.
Article in English | MEDLINE | ID: mdl-22566732

ABSTRACT

Scrub typhus is a rickettsial disease caused by Orientia tsutsugamushi, one of the most common infectious diseases in the Asia-Pacific region. It has been reported from northern, eastern, and southern India, and its presence has been documented in at least 11 Indian states. However, scrub typhus meningoencephalitis has not been well documented in Kerala. We report two cases of scrub typhus meningoencephalitis from northern Kerala. The diagnosis was made based on the clinical pictures, presence of eschar, and a positive Weil-Felix test with a titer of > 1:320. The first patient succumbed to illness due to respiratory failure and the second patient improved well.

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