ABSTRACT
An unprecedented union of multi-component reactions to construct pyrazole- and pyranopyrazole-adorned 4H-chromene from simple reactants in water at ambient temperature is reported. This innovative tactic has integrated two distinct four-component reactions (4CRs) that occur transiently to form four new heterocycles via ten covalent bonds in a single step.
ABSTRACT
Synthesis of the 2-aza analogues of pyrrolizidine and spirooxindole-2-azapyrrolizidine hybrid, a spiro-tetracyclic scaffold possessing multiple contiguous stereocenters, by an exclusive regio-, chemo-, and diastereoselective multicomponent reaction in water is reported. This logical and didactical tactic has integrated the principles of an ideal organic synthesis, privileged substructure-based diversity-oriented synthesis, and biology-oriented synthesis to access hybrid heterocyclic scaffolds.
Subject(s)
Aza Compounds/chemical synthesis , Pyrrolizidine Alkaloids/chemical synthesis , Water/chemistry , Catalysis , Cyclization , Molecular Structure , Solubility , StereoisomerismABSTRACT
In the title compound, C(15)H(14)N(4)O, the pyrazole ring is aligned at 88.23â (4)° with respect to the aromatic ring and at 3.75â (4)° with respect to the pyran ring. In the crystal, N-Hâ¯N hydrogen bonds link adjacent mol-ecules into a linear chain motif. C-Hâ¯N inter-actions are also observed.
ABSTRACT
In he title compound, C(13)H(16)N(4)O(3), the pyrazole ring is planar (r.m.s. deviation = 0.054â Å). The pyran ring is not planar; the mean plane makes a dihedral angle of 1.9â (1)° with the pyrazole ring. In the crystal structure, inter-molecular N-Hâ¯N and N-Hâ¯O inter-actions lead to a linear chain motif.
ABSTRACT
In the title compound, C(23)H(22)N(2)O(3), the pyran ring adopts a twisted boat conformation. The tolyl rings and carboxyl-ate group are attached to the pyran ring with torsion angles of -77.1â (2), 59.5â (3) and 17.8â (3)°, respectively. The ethyl group is disordered over two orientations with a site-occupancy ratio of 0.508â (5):0.492â (5). In the crystal, mol-ecules are linked by N-Hâ¯N and N-Hâ¯O hydrogen bonds, generating a chain running the a axis. Weak C-Hâ¯O, C-Hâ¯N and C-Hâ¯π inter-actions are also observed.