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1.
Hernia ; 2024 May 09.
Article in English | MEDLINE | ID: mdl-38722399

ABSTRACT

PURPOSE: While research on inguinal hernias is well-documented, ventral/incisional hernias still require investigation. In India, opinions on laparoscopic ventral hernia repair (LVHR) techniques are contested. The current consensus aims to standardize LVHR practice and identify gaps and unfulfilled demands that compromise patient safety and therapeutic outcomes. METHODS: Using the modified Delphi technique, panel of 14 experts (general surgeons) came to a consensus. Two rounds of consensus were conducted online. An advisory board meeting was held for the third round, wherein survey results were discussed and the final statements were decided with supporting clinical evidence. RESULTS: Experts recommended intraperitoneal onlay mesh (IPOM) plus/trans-abdominal retromuscular/extended totally extraperitoneal/mini- or less-open sublay operation/transabdominal preperitoneal/trans-abdominal partial extra-peritoneal/subcutaneous onlay laparoscopic approach/laparoscopic intracorporeal rectus aponeuroplasty as valid minimal access surgery (MAS) options for ventral hernia (VH). Intraperitoneal repair technique is the preferred MAS procedure for primary umbilical hernia < 4 cm without diastasis; incisional hernia in the presence of a vertical single midline incision; symptomatic hernia, BMI > 40 kg/m2, and defect up to 4 cm; and for MAS VH surgery with grade 3/4 American Society of Anaesthesiologists. IPOM plus is the preferred MAS procedure for midline incisional hernia of width < 4 cm in patients with a previous laparotomy. Extraperitoneal repair technique is the preferred MAS procedure for L3 hernia < 4 cm; midline hernias < 4 cm with diastasis; and M5 hernia. CONCLUSION: The consensus statements will help standardize LVHR practices, improve decision-making, and provide guidance on MAS in VHR in the Indian scenario.

2.
Indian J Physiol Pharmacol ; 39(2): 145-8, 1995 Apr.
Article in English | MEDLINE | ID: mdl-7649603

ABSTRACT

The biochemical effect of S-1,3-butanediol on streptozotocin induced diabetic rats was studied. Rats were made diabetic by the intraperitoneal injection of 40 mg/kg body weight streptozotocin in sodium citrate buffer. A dosage of 25 mmol/kg body weight of S-1,3-butanediol was injected intraperitoneally for treatment. The streptozotocin induced diabetic rats showed a marked increase in blood glucose level, and significant increase in the level of cholesterol, triglycerides and free fatty acids. The glycogen levels in liver and kidney were greatly decreased in diabetic rats. Treatment with butanediol normalised the glucose and glycogen level but had no significant effect on protein and lipid levels.


Subject(s)
Blood Glucose/drug effects , Butylene Glycols/pharmacology , Diabetes Mellitus, Experimental/drug therapy , Animals , Blood Glucose/analysis , Blood Glucose/metabolism , Blood Proteins/drug effects , Blood Proteins/metabolism , Butylene Glycols/administration & dosage , Butylene Glycols/therapeutic use , Cholesterol/blood , Diabetes Mellitus, Experimental/blood , Disease Models, Animal , Fatty Acids, Nonesterified/blood , Glycogen/metabolism , Injections, Intraperitoneal , Kidney/drug effects , Kidney/metabolism , Liver/drug effects , Liver/metabolism , Male , Rats , Stereoisomerism , Streptozocin/administration & dosage , Streptozocin/toxicity , Triglycerides/blood
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