ABSTRACT
Pesticide usage is one of the significant issues in modern agricultural practices; hence, monitoring pesticide content and its degradation is of utmost importance. A novel and simple one-pot deep eutectic solvent-based solvothermal method has been developed for the synthesis of FeVO4/reduced graphene oxide (FeV/RGO) nanocomposite. The band gap of FeV decreased upon anchoring with RGO. Enhanced activity in the detection and photocatalytic degradation has been achieved in the FeV/RGO nanocomposite compared to pure FeV and RGO. FeV/RGO was used to modify glassy carbon electrode (GCE), and the fabricated electrode was evaluated for its electrochemical detection of methyl parathion (MP). The amperometric technique was found to be more sensitive with a 0.001-260 µM (two linear ranges; 0.001-20 and 25-260 µM) wide linear range and low limit of detection value (0.70 nM). The practical applicability of modified GCE is more selective and sensitive to real samples like river water and green beans. Photocatalytic degradation of MP has been examined using FeV, RGO, and FeV/RGO nanocomposite. FeV/RGO managed to degrade 95% of MP under solar light in 80 min. Degradation parameters were optimized carefully to attain maximum efficiency. Degradation intermediates were identified using liquid chromatography-mass spectrometry analysis. The degradation mechanism has been studied in detail. FeV/RGO could serve as a material of choice in the field of electrochemical sensors as well as heterogeneous catalysis toward environmental remediation.
ABSTRACT
A MoS2-supported-calix[4]arene (MoS2-CA4) nanocatalyst was used for efficient synthesis of 2,4,5-trisubstituted imidazole derivatives from 1-(4-nitrophenyl)-2-(4-(trifluoromethyl)phenyl)ethane-1,2-dione, aldehydes and ammonium acetate under solvent-free conditions. Reusability of the catalyst up to five cycles without any significant loss in the yields of the product is the unique feature of this heterogeneous solid catalysis. Furthermore, the noteworthy highlights of this method are safe reaction profiles, broad substrate scope, excellent yields, economical, solvent-free, and simple workup conditions. All synthesized compounds were evaluated for their in vitro antitubercular (TB) activity against Mycobacterium tuberculosis (Mtb) H37Rv. Among the screened compounds 3c, 3d, 3f, 3m, and 3r had MIC values of 2.15, 2.78, 5.75, 1.36, and 0.75 µM, respectively, and exhibited more potency than the reference drugs pyrazinamide (MIC: 3.12 µM), ciprofloxacin (MIC: 4.73 µM), and ethambutol (7.61 µM). Besides, potent compounds (3c, 3d, 3f, 3m, and 3r) have been tested for inhibition of MabA (ß-ketoacyl-ACP reductase) enzyme and cytotoxic activity against mammalian Vero cell line. A molecular docking study was carried out on the MabA (PDB ID: 1UZN) enzyme to predict the interactions of the synthesized compounds. The results of the in vitro anti-TB activity and docking study showed that synthesized compounds have a strong anti-TB activity and can be adapted and produced more effectively as a lead compound.
