Subject(s)
Pemphigus/diagnosis , Tongue Diseases/etiology , Administration, Oral , Anti-Bacterial Agents/administration & dosage , Drug Therapy, Combination/methods , Humans , Male , Middle Aged , Mouth Mucosa/pathology , Pemphigus/complications , Pemphigus/drug therapy , Prednisolone/administration & dosage , Tongue/pathology , Tongue Diseases/diagnosis , Tongue Diseases/drug therapy , Treatment OutcomeABSTRACT
Periorbital pigmentation is a commonly encountered condition which presents clinically as bilateral round, oval or semicircular homogenous dark brown pigmented macules in the periocular region. It may influence quality of life of an individual with its strong psychological impact. We present a case of middle-aged female patient, who had periorbital pigmentation as a manifestation of acanthosis nigricans. On evaluation, she was found to have hypertension, hyperglycemia, and dyslipidemia and she fulfilled the criteria for metabolic syndrome. We believe, it is important to evaluate the patients who present as periorbital pigmentation with clinical features of acanthosis nigricans for underlying metabolic syndrome.
ABSTRACT
Pigmented transverse nasal band (PTNB) is an interesting morphological entity mainly of cosmetic concern. It is believed to be related to a defect in the development of the nasal cartilages and bones from childhood to adolescence. Some patients may have genetic predisposition. It is asymptomatic in nature and may be associated with certain dermatological conditions such as seborrheic diathesis, dermatosis papulosa nigra, ichthyosis, atopic dermatitis, acne vulgaris, psoriasis, and seborrheic melanosis.
Subject(s)
Facial Dermatoses , Hyperpigmentation , Nose , Facial Dermatoses/drug therapy , Facial Dermatoses/etiology , Female , Humans , Hyperpigmentation/drug therapy , Hyperpigmentation/etiology , Nose/embryology , Young AdultABSTRACT
INTRODUCTION: Chronic spontaneous urticaria (CSU) is a challenging condition to treat and it significantly affects quality of life. Bacterial, viral, parasitic, and fungal infections have been associated with triggering and/or perpetuating urticaria in certain individuals. There is a paucity of literature on CSU associated with Malassezia infection. METHODS AND RESULTS: We present a case series of five patients with CSU without angioedema in whom we observed temporal association of Malassezia infection with CSU. The presence of Malassezia was confirmed by clinical examination, Wood's lamp, and KOH examination. The patients with CSU experienced improvement after specific antifungal therapy. CONCLUSIONS: Malassezia infection may be associated with recurrent and chronic urticaria in a certain group of susceptible patients and thus specific targeted therapy against it might result in complete remission of urticaria along with clearing of the infection.
Subject(s)
Dermatomycoses/diagnosis , Dermatomycoses/microbiology , Malassezia , Urticaria/diagnosis , Urticaria/microbiology , Adolescent , Adult , Angioedema , Antifungal Agents/therapeutic use , Chronic Disease , Dermatomycoses/drug therapy , Female , Humans , Male , Urticaria/drug therapySubject(s)
Angioedema/diagnosis , Developing Countries , Facial Dermatoses/diagnosis , Leprosy, Multibacillary/diagnosis , Sinusitis/diagnosis , Adolescent , Angioedema/drug therapy , Angioedema/pathology , Biopsy , Chronic Disease , Clofazimine/therapeutic use , Dapsone/therapeutic use , Diagnosis, Differential , Drug Therapy, Combination , Facial Dermatoses/drug therapy , Facial Dermatoses/pathology , Follow-Up Studies , Humans , India , Leprosy, Multibacillary/drug therapy , Leprosy, Multibacillary/pathology , Male , Rifampin/therapeutic use , Sinusitis/drug therapy , Sinusitis/pathology , Skin/pathologyABSTRACT
Leprosy is a chronic granulomatous infectious multisystem disease that may present with protean manifestations. It mimics many systemic and dermatological disorders. Here we report a case in which an elderly female presented with malar rash, intermittent fever, and arthralgia. Her diagnosis was significantly delayed due to a close clinical resemblance to systemic lupus erythematosus. It is important to be aware of such manifestations of leprosy and improve awareness of it in clinicians to avoid misdiagnosis and delay in treatment.
Subject(s)
Leprosy, Tuberculoid/diagnosis , Leprosy, Tuberculoid/drug therapy , Antibiotics, Antitubercular/therapeutic use , Diagnosis, Differential , Female , Humans , Leprostatic Agents/therapeutic use , Lupus Erythematosus, Systemic/diagnosis , Middle Aged , Skin Diseases/diagnosis , Treatment OutcomeABSTRACT
Nail involvement in pemphigus vulgaris (PV) is an unusual clinical finding. The most common clinical manifestations include chronic paronychia and onychomadesis. We report an adult female patient with PV who initially presented with chronic paronychia of multiple fingernails and toenails before the onset of vesiculobullous eruptions. Later on, after complete resolution, there was recurrence of pemphigus presenting as hemorrhagic paronychia of the left index finger. Systemic treatment with corticosteroids and azathioprine led to complete resolution of mucocutaneous lesions as well as nail manifestations. Thus, chronic treatment-resistant paronychia may be an early and important sign of generalized pemphigus in certain patients.
