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1.
Article in English | MEDLINE | ID: mdl-38896214

ABSTRACT

According to William Anthony's "Recovery from mental illness: the guiding vision of the mental health service system in the 1990s," mental health recovery means "changing one's attitudes, values, feelings, goals, and skills in order to live a satisfying life within the limitations caused by illness." This seminal work served as an overarching goal, a call to action, and a roadmap for the enhancement of psychiatric recovery. Unfortunately, from many viewpoints, the goals encouraged by Anthony have not been achieved. Through semi-structured interviews with psychiatry clinicians and senior faculty members, this article aims to elucidate the current status of psychiatric recovery, how the movement progressed to this point, and where we could go from here. The development of the recovery movement will be discussed, along with its assumptions and explicit goals. The interviews focus on the extent to which these goals have been achieved, barriers to progress, whether goals should be revised, and how to achieve these goals.

2.
Community Ment Health J ; 60(5): 885-897, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38431704

ABSTRACT

Individuals with psychiatric illness believe that voting is important. However, these individuals have lower rates of voting when compared to the general population. A survey of psychiatrically hospitalized adult patients was conducted to assess perceptions of and barriers to voting in patients with psychiatric illness. Data from 113 surveys was analyzed. A majority of survey participants agreed that they cared about voting, that their vote made a difference, and that their vote was important. 74% of individuals reported previously experiencing at least one barrier when exercising their right to vote. The most commonly experienced barriers reported were not having enough information to make an informed choice, not knowing where to vote, not having transportation, and not being registered to vote. Individuals who encountered a higher number of barriers in the past had a higher chance of encountering barriers more often. In conclusion, a high percentage of individuals with mental illness severe enough to warrant hospitalization have experienced barriers to voting, with many experiencing multiple barriers. Reduction of these barriers is important, as voting and the resultant public policies can directly affect this population's mental health and access to both mental and physical healthcare services.


Subject(s)
Inpatients , Mental Disorders , Politics , Humans , Female , Male , Adult , Middle Aged , Mental Disorders/psychology , Mental Disorders/therapy , Inpatients/psychology , Surveys and Questionnaires , Power, Psychological , Aged , Young Adult , Voting
3.
J Nerv Ment Dis ; 211(12): 910-918, 2023 12 01.
Article in English | MEDLINE | ID: mdl-37983367

ABSTRACT

ABSTRACT: The COVID-19 pandemic has had extensive impacts on mental health care delivery. Anecdotal observations of inpatient care teams at Pennsylvania Psychiatric Institute suggested increased patient acuity during the pandemic. The authors found no consensus definition for measuring psychiatric acuity in the literature. We performed an interrupted time series analysis to identify whether COVID-19 was associated with changes in several hospital parameters that might reflect our patients' access to psychiatric services and acuity. We found increases in inpatient parameters for length of stay, rates of involuntary admissions, and the incidence of restraints, seclusion, and 1:1 observation orders. Observing these increasing trends can inform mitigation efforts to improve the quality of mental health care treatment and care delivery. We suggest the use of these metrics for objective measurements of psychiatric acuity.


Subject(s)
COVID-19 , Mental Disorders , Humans , COVID-19/epidemiology , Hospitals, Psychiatric , Pandemics , Hospitalization , Delivery of Health Care , Mental Disorders/epidemiology , Mental Disorders/therapy
4.
Psychiatr Serv ; 74(12): 1291-1293, 2023 Dec 01.
Article in English | MEDLINE | ID: mdl-37287229

ABSTRACT

The American Medical Association adopted a resolution in June 2022 recognizing voting as a social determinant of health. As psychiatric professionals and trainees with experience in civic health, the authors argue that psychiatrists must consider the relationship between voting and mental health as part of care delivery. People with psychiatric illness can experience unique barriers to voting and garner mental health benefits from civic engagement. Provider-led activities to promote voting are accessible and simple. Given the benefits of voting, and the availability of interventions to foster voter engagement, psychiatrists have an obligation to promote voting access among their patients.


Subject(s)
Mental Disorders , Psychiatry , United States , Humans , Mental Disorders/therapy , Mental Health , Politics
5.
Community Ment Health J ; 59(3): 498-506, 2023 04.
Article in English | MEDLINE | ID: mdl-36315332

ABSTRACT

Individuals with mental illness often face barriers to voting. One of the primary barriers is not being registered to vote. This paper describes voter support activities (VSAs) provided to hospitalized adults on the acute inpatient psychiatric units at Pennsylvania Psychiatric Institute. During the six weeks preceding the 2020 general election, adult inpatients were offered six VSAs and an optional survey examining previous voting behaviors and barriers encountered to voting. VSAs included checking voter registration status and polling location, completing a paper or electronic voter registration application, and requesting a mail-in ballot. Of 189 patients approached, 119 individuals participated in the survey and 60 individuals utilized at least one VSA. This project demonstrates that VSAs are a welcome and feasible resource for psychiatrically hospitalized adults. Psychiatric providers can serve an important role in promoting access to voting-related activities for their patients.


Subject(s)
Health Equity , Mental Disorders , Adult , Humans , Inpatients , Politics , Mental Disorders/therapy , Pennsylvania
6.
J Subst Abuse Treat ; 121: 108199, 2021 02.
Article in English | MEDLINE | ID: mdl-33357608

ABSTRACT

Since 2000, opioid use disorder (OUD) has become an epidemic in the United States with more than 600,000 total deaths and a $51 billion annual cost. Patients with OUD require services from community-based organizations, local and state health departments, and health systems, all of which necessitate communication and collaboration among these groups to develop an effective strategy for diagnosis, treatment, and coordination of care. Academic health centers (AHCs) are poised to make significant contributions to the care of patients with OUD given in-house expertise across multiple medical specialties and the mission to care for patients in need. Despite the potential for AHCs to provide necessary services and address this public health crisis, progress has been slow. Many AHCs lack a clear roadmap for moving this agenda forward in their local regions. In response to rising deaths due to OUD, the authors' AHC undertook a significant redesign effort to facilitate the necessary processes and interdepartmental collaboration to provide patient-centered, comprehensive care for patients with OUD. In this article, using an organizational development framework (McKinsey 7S model), the authors describe their transformation process, and articulate strategies and potential barriers to implementing this framework. The goal of the article is to highlight the structural, procedural, and cultural changes that have occurred in one AHC so we can assist other AHCs in addressing the opioid epidemic.


Subject(s)
Academic Medical Centers/organization & administration , Analgesics, Opioid , Change Management , Opioid Epidemic , Academic Medical Centers/trends , Humans , Opioid-Related Disorders/epidemiology , Organizational Innovation , Organizational Objectives , Public Health , Quality Assurance, Health Care , United States
7.
Psychosomatics ; 59(4): 349-357, 2018.
Article in English | MEDLINE | ID: mdl-29449024

ABSTRACT

BACKGROUND: Diagnosis and treatment of alcohol use disorders and their sequelae are common clinical questions for the consultation-liaison psychiatrist. At an urban, academic medical center, the authors consulted on several patients whose consumption of alcohol included nonbeverage forms of alcohol, (described in the literature as surrogate alcohols, nonbeverage alcohols, e.g., mouthwash). METHODS: The authors describe 4 patients who presented with surrogate alcohol consumption. The authors review the clinical issues and literature related to surrogate alcohol use. The authors describe the array of substances, which either contain ethanol, but are not intended for drinking, or which contain other intoxicating alcohols (e.g., methanol), that are consumed in lieu of traditional beverage alcohol. Furthermore, the authors discuss standard medical treatment interventions for ethanol and non-ethanol based alcohols. The authors propose a screening tool, the surrogate alcohol questionnaire, a tool to facilitate better recognition of surrogate alcohol use.


Subject(s)
Alcohol Drinking/psychology , Alcoholism/diagnosis , Ethanol/poisoning , Methanol/poisoning , Mouthwashes/poisoning , Surveys and Questionnaires , Adult , Alcoholism/psychology , Female , Humans , Male , Middle Aged
8.
J Patient Exp ; 2(1): 13-20, 2015 May.
Article in English | MEDLINE | ID: mdl-28725811

ABSTRACT

OBJECTIVES: Acquiring communication and interpersonal skills is an important part of providing patient-centered care and improving patient satisfaction. This study explores whether residents' own values about patient communication can be influenced by training. METHODS: As part of service excellence, a three-hour communication skills training in AIDET™ (Acknowledge, Introduce, Duration, Explanation, Thank You) was delivered to first and second Post-Graduate Year (PGY) residents (n = 123). A survey was designed to measure the value of patient communication and administered pre/post communication skills training. RESULTS: Residents' scores about communication values improved significantly for all areas pre- to post-training for patient communication skills (p<0.04). After training, there was little difference by medical specialty, other than surgical specialties, which showed the greatest increase in valuing requesting permission (p=0.034). Gender was also not associated with differences in values, except men showed a greater increase in valuing sitting down (p=0.021) and introductions (p=0.005) than women who already valued these specific behaviors prior to training. CONCLUSIONS: Residents value communication, and AIDET™ training is a useful tool to increase the values of good communication and interpersonal skills to enhance service excellence.

10.
Psychooncology ; 22(11): 2565-75, 2013 Nov.
Article in English | MEDLINE | ID: mdl-23873790

ABSTRACT

OBJECTIVE: It is well documented that stress is associated with negative health outcomes in cancer patients. The purpose of this study was to assess the effects of a novel mindfulness intervention called mindfulness-based art therapy (MBAT) versus standard educational support, on indices of stress and quality of life in breast cancer patients with high stress levels. METHODS: A total of 191 women were enrolled, stratified by age and stress level, and randomized to receive either an 8-week MBAT intervention or a breast cancer educational support program of equal time and duration. Psychosocial stress was measured using the Symptoms Checklist-90-Revised, and quality of life was measured using the Medical Outcomes Study Short-Form Health Survey at baseline, immediately post-intervention, and at 6 months. RESULTS: Results showed overall significant improvements in psychosocial stress and quality of life in both the MBAT and educational support groups immediately post-intervention; however, participants with high stress levels at baseline had significantly improved overall outcomes only in the MBAT group, both immediately post-intervention and at 6 months. In addition, at 6 months follow-up, participants attending five or more sessions trended toward retaining treatment effects better in the MBAT than in the control group. Finally, black women and white women were similar in terms of how they benefited from the MBAT intervention, even though white participants tended to have higher educational level and marital status. CONCLUSIONS: In conclusion, MBAT is associated with significant, sustained benefits across a diverse range of breast cancer patients, particularly those with high stress levels.


Subject(s)
Art Therapy/methods , Breast Neoplasms/therapy , Mindfulness/methods , Patient Education as Topic/methods , Quality of Life/psychology , Stress, Psychological/therapy , Adaptation, Psychological , Adult , Aged , Aged, 80 and over , Breast Neoplasms/psychology , Female , Follow-Up Studies , Health Status , Humans , Middle Aged , Socioeconomic Factors , Stress, Psychological/diagnosis , Stress, Psychological/psychology , Treatment Outcome
11.
Stress Health ; 28(5): 397-407, 2012 Dec.
Article in English | MEDLINE | ID: mdl-23129559

ABSTRACT

This study employed functional magnetic resonance imaging to evaluate changes in cerebral blood flow (CBF) associated with the Mindfulness-based Art Therapy (MBAT) programme and correlate such changes to stress and anxiety in women with breast cancer. Eighteen breast cancer patients were randomized to the MBAT or education control group. The patients received the diagnosis of breast cancer between 6 months and 3 years prior to enrollment and were not in active treatment. The age of participants ranged from 52 to 77 years. A voxel-based analysis was performed to assess differences at rest, during meditation and during a stress task. The anxiety sub-scale of the Symptoms Checklist-90-Revised was compared with changes in resting CBF before and after the programmes. Subjects in the MBAT arm demonstrated significant increases in CBF at rest and during meditation in multiple limbic regions, including the left insula, right amygdala, right hippocampus and bilateral caudate. Patients in the MBAT programme also had a significant correlation between increased CBF in the left caudate and decreased anxiety scores. In the MBAT group, responses to a stressful cue resulted in reduced activation of the posterior cingulate. The results demonstrate that the MBAT programme was associated with significant changes in CBF, which correlated with decreased anxiety over an 8-week period.


Subject(s)
Anxiety/therapy , Brain/physiopathology , Breast Neoplasms/physiopathology , Cerebrovascular Circulation/physiology , Meditation/psychology , Stress, Psychological/therapy , Aged , Anxiety/psychology , Breast Neoplasms/psychology , Female , Humans , Magnetic Resonance Imaging , Middle Aged , Stress, Psychological/psychology , Treatment Outcome
12.
Med Decis Making ; 32(2): 327-36, 2012.
Article in English | MEDLINE | ID: mdl-21685377

ABSTRACT

PURPOSE: To measure the extent of informed decision making (IDM) about prostate cancer screening in physician-patient encounters, describe the coding process, and assess the reliability of the IDM measure. METHODS: Audiorecoded encounters of 146 older adult men and their primary care physicians were obtained in a randomized controlled trial of mediated decision support related to prostate cancer screening. Each encounter was dual coded for the presence or absence of 9 elements that reflect several important dimensions of IDM, such as information sharing, patient empowerment, and engaging patients in preference clarification. An IDM-9 score (range = 0-9) was determined for each encounter by summing the number of elements that were coded as present. Estimates of coding reliability and internal consistency were calculated. RESULTS: Male patients tended to be white (59%), married (70%), and between the ages of 50 and 59 (70%). Physicians tended to be white (90%), male (74%), and have more than 10 years of practice experience (74%). IDM-9 scores ranged from 0 to 7.5 (mean [SD], 2.7 [2.1]). Reliability (0.90) and internal consistency (0.81) of the IDM-9 were both high. The IDM dimension observed most frequently was information sharing (74%), whereas the dimension least frequently observed was engagement in preference clarification (3.4%). CONCLUSIONS: In physician-patient encounters, the level of IDM concerning prostate cancer screening was low. The use of a dual-coding approach with audiorecorded encounters produced a measure of IDM that was reliable and internally consistent.


Subject(s)
Decision Making , Early Detection of Cancer , Patient Education as Topic , Patient Participation , Prostatic Neoplasms/diagnosis , Aged , Comprehension , Humans , Male , Middle Aged , Physician-Patient Relations , Primary Health Care
13.
Patient Educ Couns ; 83(2): 240-6, 2011 May.
Article in English | MEDLINE | ID: mdl-20619576

ABSTRACT

OBJECTIVE: This randomized trial was conducted to assess the impact of a mediated decision support intervention on primary care patient prostate cancer screening knowledge, decisional conflict, informed decision making (IDM), and screening. METHODS: Before a routine office visit, 313 male patients eligible for prostate cancer screening completed a baseline telephone survey and received a mailed brochure on prostate cancer screening. At the visit, participants were randomized to either an enhanced intervention (EI) or a standard intervention (SI) group. Before meeting with their physician, EI Group men had a nurse-led "decision counseling" session, while SI Group men completed a practice satisfaction survey. An endpoint survey was administered. Survey data, encounter audio-recordings, and chart audit data were used to assess study outcomes. RESULTS: Knowledge increased in the EI Group (mean difference of +0.8 on a 10-point scale, p=0.001), but decisional conflict did not change (mean difference of -0.02 on a 4-point scale, p=0.620). The EI Group had higher IDM (rate ratio=1.30, p=0.029) and lower screening (odds ratio=0.67, p=0.102). CONCLUSION: Nurse-mediated decision counseling increased participant prostate cancer screening knowledge, and influenced informed decision making and screening. PRACTICE IMPLICATIONS: Nurses trained in decision counseling can facilitate shared decision making about screening.


Subject(s)
Decision Support Systems, Clinical/instrumentation , Diagnosis, Differential , Early Detection of Cancer/methods , Patient Education as Topic/methods , Physician-Patient Relations , Prostatic Neoplasms/diagnosis , Adult , Aged , Communication , Early Detection of Cancer/instrumentation , Health Care Surveys , Humans , Male , Men's Health , Middle Aged , Multivariate Analysis , Patient Satisfaction , Risk , Risk Assessment/methods , Social Support , Tape Recording
14.
Psychosomatics ; 51(6): 520-7, 2010.
Article in English | MEDLINE | ID: mdl-21051685

ABSTRACT

BACKGROUND: The treatment of psychiatric illnesses, prevalent in the general hospital, requires broadly trained providers with expertise at the interface of psychiatry and medicine. Since each hospital operates under different economic constraints, it is difficult to establish an appropriate ratio of such providers to patients. OBJECTIVE: The authors sought to determine the current staffing patterns and ratios of Psychosomatic Medicine practitioners in general hospitals, to better align manpower with clinical service and educational requirements on consultation-liaison psychiatry services. METHOD: Program directors of seven academic Psychosomatic Medicine (PM) programs in the Northeast were surveyed to establish current staffing patterns and patient volumes. Survey data were reviewed and analyzed along with data from the literature and The Academy of Psychosomatic Medicine (APM) fellowship directory. RESULTS: Staffing patterns varied widely, both in terms of the number and disciplines of staff providing care for medical and surgical inpatients. The ratio of initial consultations performed per hospital bed varied from 1.6 to 4.6. CONCLUSION: Although staffing patterns vary, below a minimum staffing level, there is likely to be significant human and financial cost. Efficient sizing of a PM staff must be accomplished in the context of a given institution's patient population, the experience of providers, the presence/absence and needs of trainees, and the financial constraints of the department and institution. National survey data are needed to provide benchmarks for both academic and nonacademic PM services.


Subject(s)
Hospitals, General , Physicians/supply & distribution , Psychosomatic Medicine , Humans , New England , Pilot Projects , Surveys and Questionnaires , Workforce
15.
Psychiatr Clin North Am ; 33(2): 409-22, 2010 Jun.
Article in English | MEDLINE | ID: mdl-20385344

ABSTRACT

Breast cancer is a relatively common diagnosis for American women and depressive symptoms occur in many women with breast cancer. Identification of women with breast cancer and concomitant depressive symptoms and mood disorders requires particular attention by heath care providers, and may be aided by the administration of a variety of diagnostic and/or screening tools. Insomnia is also a significant problem for women with breast cancer at various stages of diagnosis and treatment, including after remission. Although many studies on the treatment of depression in women with breast cancer have been done, and the data do point to the efficacy of several antidepressants in this population, there are no data to support the widely held hypothesis that treatment of depression in patients with breast cancer may positively affect morbidity and mortality. Breast cancer treatments may give rise to depressive symptoms and this should be considered in the approach to pharmacotherapy. Several psychotherapeutic modalities offer relief of the symptoms and syndromes of depression in breast cancer. Future research can answer the question of which approach is most appropriate for which patients, and whether therapy can improve a variety of health outcomes and survival for women with breast cancer.


Subject(s)
Breast Neoplasms/psychology , Depression/diagnosis , Depression/therapy , Sleep Wake Disorders/diagnosis , Sleep Wake Disorders/therapy , Adult , Affect/drug effects , Antidepressive Agents/therapeutic use , Antineoplastic Agents, Hormonal/adverse effects , Breast Neoplasms/drug therapy , Depression/drug therapy , Depression/etiology , Female , Humans , Middle Aged , Psychotherapy/methods , Sleep Wake Disorders/drug therapy , Sleep Wake Disorders/etiology , Time Factors , Treatment Outcome
16.
Curr Psychiatry Rep ; 11(3): 205-10, 2009 Jun.
Article in English | MEDLINE | ID: mdl-19470282

ABSTRACT

Prostate cancer is now a chronic condition. Screening, diagnosis, and treatment pose specific psychosocial challenges for men diagnosed and surviving with prostate cancer. Depression, anxiety, and cognitive impairment lead to emotional distress and difficulty coping. Treatments for psychosocial distress are targeted at couples and individuals. Lifestyle modification may improve coping and quality-of-life indicators.


Subject(s)
Prostatic Neoplasms/diagnosis , Psychosomatic Medicine , Adaptation, Psychological , Aged , Aged, 80 and over , Androgen Antagonists/adverse effects , Androgen Antagonists/therapeutic use , Comorbidity , Depressive Disorder/epidemiology , Depressive Disorder/psychology , Erectile Dysfunction/epidemiology , Erectile Dysfunction/psychology , Humans , Life Change Events , Male , Prostatic Neoplasms/epidemiology , Prostatic Neoplasms/therapy , Quality of Life , Stress, Psychological/etiology , Stress, Psychological/psychology
17.
Psychosomatics ; 50(2): 93-107, 2009.
Article in English | MEDLINE | ID: mdl-19377017

ABSTRACT

BACKGROUND: In their current configuration, traditional reactive consultation-liaison services see a small percentage of the general-hospital patients who could benefit from their care. These services are poorly reimbursed and bring limited value in terms of clinical improvement and reduction in health-service use. METHOD: The authors examine models of cross-disciplinary, integrated health services that have been shown to promote health and lower cost in medically-complex patients, those with complicated admixtures of physical, mental, social, and health-system difficulties. CONCLUSION: Psychiatrists who specialize in the treatment of medically-complex patients must now consider a transition from traditional consultation to proactive, value-added programs and bill for services from medical, rather than behavioral, insurance dollars, since the majority of health-enhancement and cost-savings from these programs occur in the medical sector. The authors provide the clinical and financial arguments for such program-creation and the steps that can be taken as psychiatrists for medically-complex patients move to the next generation of interdisciplinary service.


Subject(s)
Psychiatry/methods , Psychophysiologic Disorders/epidemiology , Psychophysiologic Disorders/therapy , Referral and Consultation , Substance-Related Disorders/epidemiology , Substance-Related Disorders/therapy , Comorbidity , Cost-Benefit Analysis , Health Status , Humans , Mental Health Services/economics , Patient Care Team , Program Development , Psychiatry/economics , Psychophysiologic Disorders/economics , Referral and Consultation/economics , Substance-Related Disorders/economics
18.
Psychiatr Clin North Am ; 30(4): 739-59, 2007 Dec.
Article in English | MEDLINE | ID: mdl-17938043

ABSTRACT

Vitamin B12 deficiency is associated with problems in cognition, mood, psychosis, and less commonly, anxiety. Folate deficiency primarily is associated with problems in mood. Patients who have sickle cell disease, a disease of chronic pain, experience difficulties with depression, anxiety, stigma, and are at risk for substance abuse and dependence. Patients with hemophilia have benefited from advances in treatment; however, their morbidity and mortality were compounded in those who received blood products contaminated with HIV, or hepatitis B and C. Psychiatrists who practice psychosomatic medicine should expect to encounter patients with the above problems, as they are frequently seen in medical settings. Finally, most of the commonly used psychotropic medications have uncommon but potentially important hematologic side effects or may interact with the anticoagulants used in medically ill patients.


Subject(s)
Anemia, Sickle Cell/epidemiology , Central Nervous System Diseases/epidemiology , Folic Acid Deficiency/diagnosis , Folic Acid Deficiency/epidemiology , Mood Disorders/epidemiology , Pain/epidemiology , Psychophysiologic Disorders/diagnosis , Psychophysiologic Disorders/epidemiology , Vitamin B 12 Deficiency/diagnosis , Vitamin B 12 Deficiency/epidemiology , Anemia, Sickle Cell/diagnosis , Anemia, Sickle Cell/therapy , Central Nervous System Diseases/diagnosis , Central Nervous System Diseases/therapy , Comorbidity , Diagnosis, Differential , Folic Acid Deficiency/therapy , Humans , Mood Disorders/diagnosis , Mood Disorders/therapy , Pain/diagnosis , Pain Management , Vitamin B 12 Deficiency/therapy
20.
Exp Cell Res ; 312(17): 3349-59, 2006 Oct 15.
Article in English | MEDLINE | ID: mdl-16950245

ABSTRACT

HP1 is an essential heterochromatin-associated protein known to play an important role in the organization of heterochromatin as well as in the transcriptional regulation of heterochromatic and euchromatic genes both in repression and activation. Using the yeast two-hybrid system and immunoprecipitation, we report here that murine HP1alpha interacts with the preRC proteins ORC1, ORC2 and CDC6. Immunofluorescence staining and EGFP/DsRed fusion proteins revealed a colocalization of HP1alpha with ORC1, ORC2 and CDC6 in heterochromatin, supporting the notion that ORC and probably CDC6 play an important role in murine HP1alpha function. Besides that, we also observed a colocalization of HP1alpha with gamma-tubulin suggesting a centrosomal localization of HP1alpha in murine cells. To gain insight into HP1alpha function, we applied the RNAi technique. Depletion of HP1alpha leads to a slow down of cell proliferation, an aberrant cell cycle progression as well as to multinucleated cells with insufficiently organized microtubule. These results together indicate that HP1alpha exerts functions in mitosis and cytokinesis.


Subject(s)
Cell Proliferation , Chromosomal Proteins, Non-Histone/metabolism , Cytokinesis/physiology , Mitosis/physiology , Origin Recognition Complex/metabolism , Animals , Cell Cycle Proteins/metabolism , Cell Line, Tumor , Centrosome/chemistry , Chromobox Protein Homolog 5 , Chromosomal Proteins, Non-Histone/analysis , Chromosomal Proteins, Non-Histone/genetics , Mice , NIH 3T3 Cells , Nuclear Proteins/metabolism , RNA Interference , RNA, Small Interfering , Transfection , Tubulin/analysis
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