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1.
J Vet Emerg Crit Care (San Antonio) ; 32(2): 260-266, 2022 Mar.
Article in English | MEDLINE | ID: mdl-34766713

ABSTRACT

OBJECTIVE: (1) To report an unusual etiology for nontraumatic hemoabdomen in cats, and (2) to describe onset and recovery from severe, unexpected pancytopenia seen after surgical removal of a large intra-abdominal myelolipoma. CASE SUMMARY: A 14-year-old neutered male domestic shorthair cat was presented for emergent treatment of suspected nontraumatic hemoabdomen. A hyperechoic mass, with ultrasonographic echogenicity similar to fat, was found in the right cranial abdomen and believed to be associated with the mesentery. Cytological examination of abdominal fluid identified marked extramedullary hematopoiesis within the hemorrhagic effusion. Exploratory laparotomy identified a hepatic mass, which was resected, and revealed to be a hepatic myelolipoma on histopathological examination. The patient's initial recovery was uneventful. However, continued hyporexia resulted in readmission 4 days postoperatively, at which time the patient was found to have a profound, tri-lineage pancytopenia, and cytological evidence indicative of bone marrow recovery. The pancytopenia resolved with continued medical management and supportive care. NEW OR UNIQUE INFORMATION PROVIDED: Ruptured myelolipoma is not a commonly considered differential for nontraumatic hemoabdomen in cats. Furthermore, severe pancytopenia is unexpected following surgical resection of a myelolipoma. This case provides a unique clinical presentation of both nontraumatic hemoabdomen and bone marrow recovery.


Subject(s)
Adrenal Gland Neoplasms , Cat Diseases , Myelolipoma , Pancytopenia , Abdomen , Adrenal Gland Neoplasms/diagnosis , Adrenal Gland Neoplasms/veterinary , Animals , Cat Diseases/diagnosis , Cat Diseases/etiology , Cat Diseases/surgery , Cats , Hemoperitoneum/veterinary , Male , Myelolipoma/complications , Myelolipoma/diagnosis , Myelolipoma/surgery , Myelolipoma/veterinary , Pancytopenia/diagnosis , Pancytopenia/etiology , Pancytopenia/veterinary
2.
J Am Vet Med Assoc ; 257(11): 1148-1156, 2020 Dec 01.
Article in English | MEDLINE | ID: mdl-33226294

ABSTRACT

CASE DESCRIPTION: A 6-month-old sexually intact male Clumber Spaniel was evaluated because of small stature, recurrent dermatitis of the head, and progressive pigmentary hepatopathy. CLINICAL FINDINGS: Clinicopathologic findings included nonanemic hypochromic microcytosis, hypocholesterolemia, persistently high serum liver enzyme activities, and anicteric hyperbilirubinemia. Histologic examination of liver biopsy specimens collected when the dog was 6 months and 2 years of age revealed expansion and bridging of portal tracts, occasional centrilobular parenchymal collapse, scattered lymphoplasmacytic infiltrates, and dark red to brown pigment within large aggregates of macrophages, engorged bile canaliculi, and hepatocytes. The pigment failed to stain for the presence of iron, copper, bile, and glycoprotein and, when examined with polarized microscopy, emitted a yellow to green birefringence with occasional Maltese cross configurations. Further analyses confirmed marked porphyrin accumulation in blood, urine, feces, and liver tissue; protoporphyrin accumulation in RBCs and liver tissue; and a signature porphyrin profile and fluorescence peak consistent with erythropoietic protoporphyria. Advanced protoporphyric hepatopathy was diagnosed. The chronic dermatopathy was presumed to reflect protoporphyric photosensitivity. TREATMENT AND OUTCOME: Management was focused on avoiding conditions known to induce heme synthesis and catabolism, administrating ursodeoxycholic acid and antioxidants S-adenosylmethionine and vitamin E, and avoiding sunlight exposure. At follow-up at 4 years of age, the dog was stable without evidence of jaundice but with probable persistent erythropoietic protoporphyria-related solar dermatopathy. CLINICAL RELEVANCE: Clinical and histologic features of congenital erythropoietic protoporphyria and resultant protoporphyric hepatopathy, the diagnosis, and the successful management of a dog with these conditions over 4 years were described. Veterinarians should consider porphyric syndromes when unusual pigmentary hepatopathies are encountered.


Subject(s)
Dog Diseases , Liver Diseases , Protoporphyria, Erythropoietic , Animals , Bile , Dog Diseases/drug therapy , Dogs , Liver , Liver Diseases/veterinary , Male , Protoporphyria, Erythropoietic/complications , Protoporphyria, Erythropoietic/veterinary , Ursodeoxycholic Acid
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