The influence of colloid formation in a granite groundwater bentonite porewater mixing zone on radionuclide speciation.

In the context of deep geological storage of high level nuclear waste the repository will be designed as multiple barrier system including bentonite as buffer/backfill material and the host rock formation as geological barrier. The engineered barrier (bentonite) will be in contact with the host rock formation and consequently it can be expected that bentonite porewater will mix with formation groundwater. We simulate in this study the mixing of Grimsel groundwater (glacial melt water) with synthetic Febex porewater (assuming already saturated state) in a batch-type study and investigate the formation of colloids by laser-induced breakdown detection (LIBD) and SEM-EDX as well as the changes in radionuclide (U, Th, Eu) speciation via ultrafiltration or via time-resolved laser fluorescence spectroscopy (TRLFS) analysis in the case of Cm(III). Based on PHREEQC saturation index (SI) calculations a precipitation of calcite might be expected at low Febex porewater (FPW) content (<20%), fluorite precipitation at FPW contents <60% and gibbsite precipitation at FPW contents above 10%. The colloids generated in the mixing zone aggregate when the synthetic FPW content exceeds 10%. LIBD analysis of the time-dependent colloid generation/aggregation revealed a low concentration of colloids to be stable with an estimated plateau value around 100-200 ppt and an average colloid diameter around 30 nm after 140 days reaction time at FPW admixture >10%. SEM/EDX mostly identifies Al/Si containing colloidal phases and some sulfates could be found under certain admixture ratios. TRLFS studies show that the Cm speciation is strongly influenced by colloid formation in all solutions. In the Febex pore water/GGW mixing zone with high groundwater contents (>80%) colloids are newly formed and Cm is almost quantitatively associated with most likely polysilicilic acid colloids.

Traduzindo Freud / Traslating Freud

Após breve relato do percurso que a levou a ser tradutora de Freud, a autora apresenta alguns momentos da história da edição das obras completas de Freud e da tradução destas para o inglês pela Standard edition e para o português a partir desta. Comenta algumas críticas a estas e a partir destas e de aportes vindos, também, da tradução para o francês, reflete sobre alguns critérios de tradução para uma nova tradução. É apresentado o projeto da Nova tradução das obras psicológicas de Sigmund Freud para o português pela editora Imago e alguns de seus parâmetros. A autora encerra com algumas reflexões sobre sua experiência e uma correlação entre os ofícios de traduzir e psicanalisar. Segue como apêndice um resumo dos parâmetros adotados na nova tradução acompanhados de discussão de alguns exemplos esclarecedores (AU)

Ecdysone-controlled mRNA stability in Drosophila salivary glands: deadenylation-independent degradation of larval glue protein gene message during the larval/prepupal transition.

20-Hydroxyecdysone induces poly(A) shortening and the subsequent degradation of transcripts encoding the larval glue protein LGP-1 in Drosophila virilis late third larval instar salivary glands. Degradation concurs with the transient increase of ribonucleolytic activities in the gland cells. In vitro nuclease assays using crude cytoplasmic extracts of ecdysone-treated salivary glands demonstrate degradation to be deadenylation-independent and that the induced ribonucleolytic activities initiate the degradation of the Lgp-1 transcripts in putative single-stranded loop regions. The independence of degradation from deadenylation is also found in vivo in transformed D. melanogaster carrying a modified Lgp-1 gene.

Histologically proven extrinsic allergic alveolitis with severe obstructive pulmonary emphysema

Anamnesis: 61-year old man with progressive shortness of breath on exercise. Cough and expectoration during the last 6 years. - Exposure: Driver of cereals, massive exposure to mouldy and pest contaminated grains. Gave up his profession in 1979 due to dyspnea with short (2-3 h) latency after exposure. Since 1980 intermittent exposure during occasional jobs; renewed symptomatology. Aspergillus fumigatus detected on agar plates inoculated with material from wet areas in bathroom and kitchen. - Clinical symptoms: Barely audible vesicular breathing, barrel-shaped thorax, inspiratory-intercostal retraction. - Bodyplethysmography: Obstructive pulmonary emphysema with FEV1 0.8 l, TLC 7.8 l, RV/TLC relation 67%. - Precipitin-detection: Significantly increased IgG against Fusarium. Other moulds including Aspergillus: negative; thermophilic actinomycetes: negative; pigeon and chicken: negative; Ouchterlony with native material from patients flat: negative. - CT including HR-CT: Bilateral-substantial emphysema, no bullae, no ground glass-opacity, no signs for interstitial lung diseases, no mediastinal enlargement of lymph nodes. - Alpha-1-Antitrypsin: 1.67 to 2.3 g/l (normal range), phenotype M1. - Histology: In resected material from right-side lung-volume-resection detection of pulmonary emphysema as well as lymphocyte infiltration and numerous epitheloid cell granulomas with Langhans'giant cells without caseation assessed as residues of an exogenous allergic alveolitis. - Conclusion: In a patient with lung volume reduction surgery due to severe emphysema histologically a persistent exogenous allergic alveolitis was detected, which might have caused the emphysema.

[Ultrasound differential diagnostic aspects in cystadenoma of the pancreas]. / Sonographisch-differentialdiagnostische Aspekte beim Zystadenom des Pankreas.

AIM: Assessment of differential diagnostic criteria of cystic adenomas of the pancreas. METHOD: We rechecked on all diagnostic criteria of patients with pancreatic pseudocysts retrospectively who had been treated in our department between 1981 and 1993. RESULTS: 12 patients with cystic adenomas of the pancreas had been treated in our department i.a. 7.8% of all cystic pancreatic tumours. Histopathologically 1 microcystic and 4 macrocystic adenomas as well as 7 cystic adenocarcinomas were seen. CONCLUSION: Diagnostic ultrasound criteria are discussed. Ultrasound-guided fine--needle-biopsy (FNB) is necessary to diagnose the content as well as the status of the pancreatic cysts. The ultrasound and the fine-needle-biopsy findings are important for differentiating between cystic adenomas and pseudocysts of the pancreas.

HPLC-determination of apomorphine in a mormyrid fish, gnathonemus petersii.

Uptake of apomorphine and elimination kinetics in brain and muscle tissue of the weakly electric fish Gnathonemus petersii (Mormyridae) was determined by HPLC. 20 min exposure of the fish to apomorphine in the aquarium water (0.4 mg/l) resulted in a concentration factor of 1.09 for brain and 0.55 for muscle tissue. Elimination from brain tissue can be described with first order kinetics (t1/2 = 2.4 h).

[The histomorphology of granulomatous lipid pneumonia due to dietary fat aspiration in achalasia of the esophagus (megaesophagus)]. / Die Histomorphologie der granulomatösen Lipidpneumonie infolge Speisefettaspiration bei Achalasie des Osophagus (Megaoesophagus).

In some cases of achalasia, lungs may show characteristic granulomatous pneumonia, following non-symptomatic spill-over and aspiration of fat. The lesion is characterised by fat-containing vacuoles, necrosis, granulocytes, macrophages, some of them with lipid content, epithelioid and giant cells and fibrosis rich in lymphocytes. The histological pattern is pathognomonic and represents an entity. These alterations may be mistaken for tuberculosis and be distinguished from mineral-oil pneumonia (paraffinoma). Affected lung regions may be colonised by nontuberculous (atypical) mycobacteria.

Apomorphine and haloperidol influence electric behaviour of a mormyrid fish.

The electric behaviour of the mormyrid Gnathonemus petersii is changed by dopaminergic drugs applied to the aquarium water. The upper limit of the interpuls interval distributions is significantly shifted to shorter intervals by apomorphine-HCl (.082 - .328 mg/ml), and to longer intervals by haloperidol (.041 - .164 mg/ml). The effect of apomorphine is antagonized by haloperidol. Probably, a dopamine system is involved in the neural control of the electric organ.

[Drug-induced hepatitis after dihydralazine treatment with fatal consequences]. / Arzneimittelhepatitis nach Dihydralazin mit tödlichem Verlauf.

Adverse drug side effects of the antihypertensive substance dihydralazine have been increasingly observed in recent years. Damage is concentrated on the liver and is characterized by drug-induced hepatitis with confluent necrosis. Three cases (60 year old woman, 79 year old woman, 61 year old man) with lethal course after antihypertensive treatment, using dihydralazine are reported in this paper.

[Exogenous lipid pneumonia after occupational rapeseed oil inhalation]. / Exogene Lipidpneumonie nach beruflicher Rapsölinhalation.

A 26 year-old man developed a lipid pneumonia with an intensely granulomatous inflammation following repeated occupational exposure to aerosolized rape seed oil. The intensity of the reaction, greater than that customarily seen with vegetable oil induced pneumonias, was attributed to specific components of rape seed oil.

[Intranuclear alpha 1-antitrypsin in HBs-Ag-seronegative hepatitis B with PAS-negative globular hyaline bodies containing the complements components C4, C3, and C3-activator (author's transl)]. / Intranucleäres alpha 1-Antitrypsin bei HBsAg-seronegativer Hepatitis B mit PAS-negativen, die Komplementkomponenten C4, C3 und C3-Aktivator enthaltenden globulären hyalinen Körpern.

In the liver biopsy specimen of a 16 year old patient with HBsAg-seronegative hepatitis B PAS-negative globular hyaline bodies reacted with antibodies to the complement components C4, C3, and C3-activator, but not with antibodies to alpha 1-antitrypsin. However, alpha 1-antitrypsin could be identified in the liver cell nuclei, cytoplasm, and cell membrane. Probably, these findings are caused by an hereditary or acquired metabolic disorder.

[Atypical location of a malignant mesonephrogenic tumor. A case contribution to the nosology of female bladder neck obstruction]. / Atypische Lokalisation eines malignen mesonephrogenen Tumors. Ein kasuistischer Beitrag zur Nosologie weiblicher Blasenhalsobstrucktionen.

Description of a case of mesonephrogenic adenocarcinoma with atypical dominance of urological manifestation of the vesical neck. Reference to the difficult problems of making the histological with the help of delimited excisions of tissue in such rare, extraordinarily differentiated tumours.

[So-called hypertrophic female bladder neck obstruction]. / Zur sogennanten hypertrophischen weiblichen Blasenhalsobstruktion.

The diagnosis of female obstruction of the vesical neck deserves more attention. The hypertrophic form may be established in form of a screening already in the excretion urogramme. It is remarkable that histologically here no hyperplasia of periurethral glands is found, but a vascular hyperplasia as a sequel of primary circulatory disturbances, the hormonal dependence of which remains to be discussed.

[Primary malignant lymphoma of the central nervous system]. / Primäres malignes Lymphom des Zentralnervensystems.

Clinical and morphological observation of 56-year-old man with a primary isolated malignant non-Hodgkin's lymphoma of the central nervous system in the hypothalamus, with the formation of metastases in the space of the cerebrospinal fluid and a solitary extraneural metastasis in the epicardium. No generalised lymphoma. The histological classification is discussed. The importance of the cytology of the cerebrospinal fluid to a climical diagnosis is pointed out.

[Postbronchographic cytological findings in lung (author's transl)]. / Postbronchografische zytologische Befunde der Lunge.

A review of literature is given on histological reactions by bronchograpyhic agents. Description of cytological changes after using Visotrast "B" in biopsy materials of bronches and lungs. Cytological reactions are characteristical. Their intensity is dependent on several factors.

[Sebaceous lymphadenoma of the parotid gland (author's transl)]. / Talgdrüsenlymphadenom der Glandula parotis.

A case of sebaceous lymphadenoma close to the parotid gland--the twelfth in the literature--is presented. The morphologic findings and histogenetic considerations are reported together with a short review of literature.

[Bone fluorosis without occupational exposure in chronic renal insufficiency]. / Knochenfluorose ohne berufliche Exposition bei chronischer Niereinsuffizienz.

Report on a 70-year-old male with bone fluorosis which was ascertained radiologically, by section and fluor analysis in the bone ash. With empty professional anamnesis as cause was found the presence of a chronic renal insufficiency with simultaneously increased fluor content of drinking water. The decreased renal excretion of fluoride might have led to the pathological development in the bones. It is referred to the significance of extra-medical fluor load and the knowledge of the renal function when halogen is therapeutically used.

[Idiopathic orthostatic hypotension]. / Idiopathische orthostatische Hypotonie

The disease picture of idiopathic orthostatic hypotonia is described from a clinical and histological point of view with reference to a case treated by the present authors. The independent character of this particular ailment may be considered as resulting from the virtually uncontrollable orthostatic decreases in blood pressure in connection with the progressive disorders especially of the motor system. Also, the etiology is not yet fully understood.