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A mouse atlas of gene expression: large-scale digital gene-expression profiles from precisely defined developing C57BL/6J mouse tissues and cells.

Siddiqui, Asim S; Khattra, Jaswinder; Delaney, Allen D; Zhao, Yongjun; Astell, Caroline; Asano, Jennifer; Babakaiff, Ryan; Barber, Sarah; Beland, Jaclyn; Bohacec, Slavita; Brown-John, Mabel; Chand, Steve; Charest, David; Charters, Anita M; Cullum, Rebecca; Dhalla, Noreen; Featherstone, Ruth; Gerhard, Daniela S; Hoffman, Brad; Holt, Robert A; Hou, Juan; Kuo, Byron Y-L; Lee, Lisa L C; Lee, Stephanie; Leung, Derek; Ma, Kevin; Matsuo, Corey; Mayo, Michael; McDonald, Helen; Prabhu, Anna-liisa; Pandoh, Pawan; Riggins, Gregory J; de Algara, Teresa Ruiz; Rupert, James L; Smailus, Duane; Stott, Jeff; Tsai, Miranda; Varhol, Richard; Vrljicak, Pavle; Wong, David; Wu, Mona K; Xie, Yuan-Yun; Yang, George; Zhang, Ida; Hirst, Martin; Jones, Steven J M; Helgason, Cheryl D; Simpson, Elizabeth M; Hoodless, Pamela A; Marra, Marco A.

Proc Natl Acad Sci U S A ; 102(51): 18485-90, 2005 Dec 20.

Article in English | MEDLINE | ID: mdl-16352711

ABSTRACT

We analyzed 8.55 million LongSAGE tags generated from 72 libraries. Each LongSAGE library was prepared from a different mouse tissue. Analysis of the data revealed extensive overlap with existing gene data sets and evidence for the existence of approximately 24,000 previously undescribed genomic loci. The visual cortex, pancreas, mammary gland, preimplantation embryo, and placenta contain the largest number of differentially expressed transcripts, 25% of which are previously undescribed loci.

Subject(s)

Gene Expression Profiling , Gene Expression Regulation, Developmental/genetics , Mice, Inbred C57BL/genetics , Mice/genetics , Alternative Splicing/genetics , Animals , Multigene Family/genetics , RNA, Untranslated/genetics , Reproducibility of Results , Transcription, Genetic/genetics

ABSTRACT

Subject(s)

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