Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 4 de 4
Filter
Add more filters










Database
Language
Publication year range
1.
Asian J Anesthesiol ; 61(4): 194-197, 2023 Dec 01.
Article in English | MEDLINE | ID: mdl-38695070

ABSTRACT

Infective endocarditis (IE) remains a rare yet critically severe condition, representing a considerable diagnostic challenge, especially among patients with pre-existing structural heart anomalies. This report details the clinical journal of a 49-year-old male with a known bicuspid aortic valve who initially exhibited nonspecific symptoms, leading to rapid clinical deterioration and the emergence of uncommon complications. The patient experienced an aortic root rupture and pericardial tamponade, necessitating urgent surgical intervention. Transesophageal echocardiography (TEE) was instrumental in confirming the diagnosis and facilitating the decision to perform a Bentall's procedure. This care highlights the critical role of TEE in diagnosing complex cases of IE and the imperative for swift intervention.


Subject(s)
Cardiac Tamponade , Echocardiography, Transesophageal , Endocarditis , Humans , Male , Cardiac Tamponade/etiology , Cardiac Tamponade/diagnostic imaging , Middle Aged , Endocarditis/complications , Endocarditis/diagnostic imaging , Aortic Rupture/diagnostic imaging , Aortic Valve/diagnostic imaging , Aortic Valve/surgery
2.
J Intensive Care Med ; 34(6): 495-502, 2019 Jun.
Article in English | MEDLINE | ID: mdl-28372500

ABSTRACT

BACKGROUND: Early fluid resuscitation is a key aspect in the successful management of critically ill patients, but the optimal goal for volume control after the acute stage of critical illness remains unclear. This study aimed to evaluate the prognostic value of bioimpedance spectrometry for fluid management in critically ill patients. METHODS: In this prospective observational study, patients who consented to participate were screened within the first 24 hours of admission to a medical intensive care unit (ICU) from February 4, 2015, to January 31, 2016. Information on demographics, comorbidities, primary reasons for admission, baseline laboratory data, and ventilator or inotropic use were documented. Data of fluid intake, fluid output, and body weight were recorded for the first 3 days of ICU admission. Bioimpedance spectrometry was performed on the first and third days after ICU admission. All participants were followed until death or hospital discharge. RESULTS: Of the 140 enrolled patients (median age: 70 years, interquartile range: 60-77 years), 23 (16.4%) patients died during hospitalization. Independent predictors of hospital mortality were Acute Physiology and Chronic Health Evaluation II scores (per 1 point increase, odds ratio [OR]: 1.101) and overhydration (OH) volume on the first day (per 1 L increase, OR: 1.216). Compared to normal OH status (OH volume between -1 and 1 L), hyper OH status (OH volume < -1 L) on the third day after ICU admission was an independent predictor of hospital death (OR: 7.609). Normal OH status on the third day was associated with greater numbers of ICU-free and ventilator-free days. CONCLUSION: Bioimpedance spectrometry can be used to predict outcomes in critically ill patients. Increased OH volume on day 1 and hyper OH volume on day 3 of ICU admission are associated with a greater risk of hospital mortality. Volume status on day 3 is associated with durations of ventilator use and ICU stay.


Subject(s)
Critical Care/methods , Critical Illness/therapy , Fluid Therapy/methods , Intensive Care Units , Spectrum Analysis , Adult , Aged , Aged, 80 and over , Female , Fluid Therapy/adverse effects , Humans , Male , Middle Aged , Patient Selection , Prospective Studies , Water-Electrolyte Balance
3.
PLoS One ; 11(3): e0150061, 2016.
Article in English | MEDLINE | ID: mdl-26934189

ABSTRACT

Infection with Helicobacter pylori (H. pylori) has been linked to various gastro-intestinal diseases; nevertheless it remains to be clarified why only a minority of infected individuals develop illness. Studies from the West have indicated that the cagA gene and the associated EPIYA genotype of H. pylori is closely linked to the development of severe gastritis and gastric carcinoma; however, as yet no consistent correlation has been found among the bacteria from East Asia. In addition to genotype variation, the CagA protein undergoes fragmentation; however, the functional significance of fragmentation with respect to H. pylori infection remains unknown. In this study, we isolated 594 H. pylori colonies from 99 patients and examined the fragmentation patterns of CagA protein using immunoblotting. By analyzing the ability of the isolates to induce the host cell morphological transition to the highly invasive hummingbird phenotype, we demonstrated that H. pylori colonies with substantial CagA fragmentation are less potent in terms of causing this morphological transition. Our results uncovered a functional role for CagA fragmentation with respect to H. pylori-induced hummingbird phenotype formation and these findings suggest the possibility that the post-translational processing of CagA may be involved in H. pylori infection pathogenesis.


Subject(s)
Antigens, Bacterial/genetics , Bacterial Proteins/genetics , Helicobacter Infections/microbiology , Helicobacter pylori/genetics , Adolescent , Adult , Aged , Aged, 80 and over , DNA Fragmentation , Female , Gastric Mucosa/microbiology , Gastritis/microbiology , Genotype , Humans , Male , Middle Aged , Phenotype , Protein Processing, Post-Translational/genetics , Stomach Neoplasms/microbiology , Young Adult
4.
J Microbiol Immunol Infect ; 38(6): 409-16, 2005 Dec.
Article in English | MEDLINE | ID: mdl-16341341

ABSTRACT

Butachlor is the most commonly used herbicide in Taiwan and many other countries. It has been reported to be an indirect mutagen and carcinogen in various in vitro assay systems. Previous investigation has also demonstrated that butachlor stimulates cell proliferation, transforms normal embryonic cells, and induces stomach tumors in Spraque-Dawley rats. However, the mechanism of butachlor carcinogenicity is still not clear. In order to clarify the toxicologic and carcinogenic properties of butachlor, we proposed a metabolic pathway, and synthesized the authentic metabolites by chemical methods. In addition, we tested the mutagenicity of butachlor and these metabolites on Salmonella typhimurium. The results indicate that butachlor might manifest its carcinogenicity via the mutagenicity of its metabolic products. Although the molecular mechanism of butachlor-induced cellular toxicity is still not clear, it is likely that the cellular transformation ability of butachlor is partly associated with its mutagenicity.


Subject(s)
Acetanilides/metabolism , Acetanilides/toxicity , Herbicides/metabolism , Herbicides/toxicity , Mutagens/metabolism , Mutagens/toxicity , Salmonella typhimurium/drug effects , Salmonella typhimurium/genetics , Acetanilides/chemistry , Animals , Carcinogens/chemistry , Carcinogens/metabolism , Carcinogens/toxicity , Cell Transformation, Neoplastic , Gas Chromatography-Mass Spectrometry , Herbicides/chemistry , In Vitro Techniques , Male , Microsomes, Liver/metabolism , Mutagenicity Tests , Mutagens/chemistry , Rats , Rats, Sprague-Dawley
SELECTION OF CITATIONS
SEARCH DETAIL
...