[Organ-preserving interventions in combined therapy of children and adolescents with osteosarcoma].

An analyzed cohort consists of 50 pediatric patients with osteosarcoma receiving combined therapy in N. N. Petrov Research Institute for Oncology (1999-2010). Thirty nine of them had localized disease, 11 patients had distant metastases. The treatment scheme included neoadjuvant therapy with cisplatin and doxorubicin, surgical treatment and adjuvant therapy depended on initial response and could include cisplatin, doxorubicin, high-dose methotrexate, ifosfamide, etoposide. Four-year overall and relapse-free survival in children with localized disease was 74.3% and 69.2% accordingly. In 62% of patients were performed organ-preserving surgical interventions, in 22 patients was performed endoprosthetics, in 4 patients the defect was replaced by a bone autograft on a vascular bundle. The effectiveness of initial treatment and secondary endoprosthetics were analyzed. Six patients with lung metastases received normotermic lung chemoperfusion, 4 of them are alive and disease-free for 8 to 24 months.

[Partial replantation following proximal limb injury]. / Réimplantations partielles après traumatisme proximal des membres.

PURPOSE OF THE STUDY: Proximal replantation is a technically feasible but life-threatening procedure. Indications must be restricted to patients in good condition with a good functional prognosis. The goal of replantation must be focused not only on reimplanting the amputated limb but also on achieving a good functional outcome. For the lower limb, simple terminalization remains the best choice in many cases. When a proximal amputation is not suitable for replantation, the main aim of the surgical procedure must be to reconstruct a stump long enough to permit fitting a prosthesis preserving the function of the adjacent joint. If the proximal stump beyond the last joint is very short, it may be possible to restore some length by partial replantation of spared tissues from the amputated part. We present here the results we obtained following this policy. MATERIALS AND METHODS: This series included 16 cases of partial replantations, 14 involving the lower limb and 2 the upper limb. All were osteocutaneous microsurgical transfers. For the lower limb, all transfers recovered protective sensitivity following tibial nerve repair. The functional calcaeoplantar unit was used in 13 cases. The transfer of this specialized weight bearing tissue provided a stable distal surface making higher support unnecessary. In one case, we raised a 13-cm vascularized tibial segment covered with foot skin for additional length. For the upper limb, the osteocutaneous transfer, based on the radial artery, was not reinnervated, but this lack of sensitivity did not impair prosthesis fitting. RESULTS: One vascular failure was finally amputated. This was the only unsuccessful result. For all other patients, the surgical procedure facilitated prosthesis fitting and preserved the proximal joint function despite an initially very proximal amputation. DISCUSSION: The advantages of partial replantation are obvious compared with simple terminalization or secondary reconstruction. There is no secondary donor site and, because there is no major muscle mass in the distal fragment, the overall risk is very low compared with the risk of total proximal leg replantation.

[Current problems of vascular surgery in childhood]. / Aktual'nye voprosy angiokhirurgii detskogo vozrasta.

Under analysis are remote results of treatment of 751 children with congenital and acquired diseases of the vessels. Grounds are given for treatment of these diseases in the light of the classical syndromes of disturbed hemodynamics. The investigation of developmental and individual peculiarities of these syndromes is thought to be necessary. The leading role of microsurgical methods of treatment of such diseases of the vessels in children is stressed.

[Reconstructive plastic surgery of the esophagus in children]. / Rekonstruktivno-plasticheskaia khirurgiia pishchevoda u detei.

The article presents the authors' experiences with reconstructive-plastic operations of the esophagus in children. The esophagoplasty was performed in 60 patients with congenital and acquired diseases. Among the congenital diseases are esophageal atresia, short esophagus and Barrett's esophagus, the acquired diseases include postburn scarry injuries. The optimum method of creation of the artificial esophagus are described. Of great significance are thought to be angiosurgical and microsurgical methods of cutting out the intestinal transplants. Cases of free autotransplantation of the intestinal segments for the substitution of the injured esophagus are described. Positive results were obtained in most cases.

[Current problems in the reconstructive surgery of the locomotor apparatus in children]. / Aktual'nye voprosy rekonstruktivnoi khirurgii oporno-dvigatel'nogo apparata u detei.

The authors analyze results of treatment of 778 children with malignant and benign tumors of the bones, pseudoarthroses, amputations of lower extremities and fingers, injuries of the tendons, vessels and contused-lacerated wounds of distal phalanges of fingers. The possibility to use a precision technique for the reconstructive operations of the vessels in children is shown.

[Clinical aspects, diagnosis and surgical treatment in injuries of the iliofemoral venous segment in children]. / Klinika, diagnostika i khirurgicheskoe lechenie povrezhdenii podvzdoshno-bedrennogo venoznogo segmenta u detei.

In 1985-1991 forty patients aged from 12 days to 14 years were treated for sequelae of iatrogenic injury to the iliofemoral venous segment. Twenty-five various operations for autovenous shunting were performed: cross shunt after Palma in 15, autovenous shunt in the anatomical projection in 3, phlebolysis and ligation of the collaterals in 5 cases, extravasal correction with A. N. Vedensky's casing spiral in one case, and direct anastomosis in a newborn infant.

[Surgical treatment of extrahepatic portal hypertension in children]. / Khirurgicheskoe lechenie vnepechenochnoi portalnoi gipertenzii u detei.

In the period from 1985 to 1992 sixty-three patients aged from 7 months to 15 years were treated for the portal hypertension syndrome, 60 had the extrahepatie form. Forty-five various operations for portosystemic shunting were carried out: formation of proximal splenorenal anastomosis in 31, distal splenorenal anastomosis in 4, mesentericocaval anastomosis in 6, gastrocaval anastomisis in 2, and an atypical vascular shunt in 2 cases. Nonshunting operations were performed on 8 patients. Since 1986 39 sessions of endoscopic sclerotherapy were conducted, 16 of them were carried out in cases with esophagogastric bleeding.

[A clinico-social study of peripheral vessel anomalies in children]. / Kliniko-sotsial'noe issledovanie anomalii perifericheskikh sosudov u detei.

The authors generalize results of examinations and operative treatment of 310 children with abnormalities of the venous and lymphatic vessels. References for differential diagnostics are described and term for operative interventions are given.

[Autologous transfusion of UV-irradiated blood in the complex treatment of children with dysplasia of deep veins of the extremities]. / Autotransfuziia obluchennoi ul'travioletom krovi v kompleksnom lechenii detei s displaziei glubokikh ven konechnostei.

Under examination there were 12 patients aged from 5 till 14 years. An investigation of hemostatic potential of blood in the diseased extremity and peripheral blood was performed. A mosaic character of blood coagulative alterations in this category of patients was detected. Autotransfusion of UV-irradiated blood is a pathogenetically grounded and accessible method of correction of hemocoagulation and may be included in the complex treatment of patients with dysplasia of the profound veins of lower extremities.

[Vascular microsurgery during esophagoplasty in children]. / Mikrososudistaia khirurgiia pri ézofagoplastike u detei.

Clinico-experimental data on using the microvascular technique in plastic operations on the esophagus are described. Experiments in puppies have revealed specific features of the surgical technique, the morphology of intestinal grafts and their taking under conditions of growing organism. The microvascular technique was used in 3 patients. In 2 patients additional nutrition of the grafts was performed, in 1 patient free transplantation of small intestine grafts to the cervical and thoracic parts of the esophagus was fulfilled. Results were good.