ABSTRACT
Erythema multiforme (EM) is a rare cell-mediated immune response characterized by target or iris patches or plaques that present symmetrically on the extremities. This condition may be associated with pruritus but is usually self-limited and spontaneously resolves within 5 weeks of onset; prodromal symptoms are rare. Several known cases have been linked to vaccination, but many vaccines used in pediatric care have been reported as causative agents of EM. This case study offers an association of EM following administration of the hepatitis A and pneumococcal vaccines.
Subject(s)
Erythema Multiforme , Hepatitis A Vaccines/adverse effects , Hepatitis A , Pneumococcal Vaccines/adverse effects , Child , Erythema Multiforme/diagnosis , Erythema Multiforme/etiology , Hepatitis A/complications , Hepatitis A/prevention & control , Humans , Immunity, Cellular , Vaccination/adverse effectsABSTRACT
Cryptococcus neoformans is a yeastlike encapsulated basidiomycetous fungus that is able to cross the blood-brain barrier and cause meningitis in both immunocompetent and immunocompromised individuals. Cryptococcus neoformans has emerged as a major opportunistic pathogen because of the widespread use of immunosuppressive therapy. It causes most cryptococcal infections in humans, and disseminated infection can have cutaneous manifestations. We report a rare case of disseminated C neoformans in a 52-year-old man who underwent an orthotopic liver transplant. We also provide a concise review of the literature on C neoformans, including its associations, histology, and treatment.
