[The use of microsurgery and balneotherapy in the treatment of hyperplastic laryngitis]. / Zastosowanie mikrochirurgii i balneoterapii w skojarzonym leczeniu hiperplastycznych niezytów krtani.

The study aimed at the assessment of the clinical value of using the combined method of laryngeal microsurgery and balneotherapy in the operative treatment and prevention of recurrences of limited hyperplastic changes of the laryngeal mucosa. The study material comprised two groups of patients diagnosed and treated in the years 1991-1997 in the Lublin E.N.T. Department and Laryngological Research-Consulting Center in Iwonicz Zdrój. The I clinical group consisted of 194 patients in whom, on definite indications, micro-surgeries with Kleinsasser's method were performed and the II control group consisting of 165 subjects suffering from chronic simple inflammation of pharyngo-laryngeal mucosa without morphologic hypertrophy. Inhalant treatment was performed by means of an individual method--using inhalant devices by Thomex L-2 producing high density mist of 1-4 mu degree comminution. Isotonic Iwonicz saline-Elin 7 was used. Uniform criteria of assessment were assumed and used of direct and distant therapeutic effect (in control studies) for the whole group of patients in the study period. Obtained results were analysed statistically.

Tumor angiogenesis in patients with laryngeal cancer.

Tumor angiogenesis was evaluated in 60 patients with primary laryngeal cancer by quantitating the microvessel density with antibodies against factor VIII. The microvessel density was then correlated with T stage, N stage, histologic grade and patient survival. A direct correlation was found between increased tumor angiogenesis and T stage, histologic grade and a shorter survival rate.

Expression of bcl-2 protein in lymphocytes of patients with laryngeal carcinoma.

The aim of this study was to evaluate the expression of bcl-2 protein in lymphocytes of the peripheral blood of patients with laryngeal carcinoma. The protein product of the proto-oncogene bcl-2 is a physiological inhibitor of apoptosis or programmed cell death. Since we believe that apoptosis is involved in the regulation of an immune response to a cancer process, we tried to show how this mechanism works in laryngeal carcinoma in comparison with normal peripheral blood lymphocytes of healthy controls. To explain the significance of this molecule's expression, we used flow cytometry to examine the expression of bcl-2 in T lymphocytes from the peripheral blood of 23 patients with laryngeal carcinoma and 20 healthy controls. Our study revealed that the expression of bcl-2 protein in T lymphocytes from the cancer patients was significantly higher than in the controls (P < 0.05). This difference in the expression of bcl-2 protein was found in both CD4 and CD8 subpopulations and was significantly higher than in the control group. In patients with laryngeal carcinoma expression of bcl-2 protein in T lymphocytes was higher in CD4 than in CD8 cells (P < 0.05). These results suggest that bcl-2 protein may interact in the regulation of apoptosis of lymphocytes, taking part in anti-cancer defence.

[A case of laryngeal carcinoma recurrence in the neck lymphatic system after total laryngectomy and combined method treatment]. / Przypadek wznowy wezlowej raka krtani u chorego po laryngektomii leczonego metoda skojarzona.

A patient with inoperable recurrence of the larynx carcinoma in lymphatic neck system after total laryngectomy was described. Nonradical surgical treatment combined with radical radiotherapy allowed to achieve a five-year symptom-free survival in this case.

[Epidemiologic and clinical tests of patients suffering from laryngeal cancer in the Lublin macro-region in the years 1991-1995]. / Badania epidemiologiczne i kliniczne chorujacych na raka krtani w latach 1991-1995 w makroregionie lubelskim.

The study of registered morbidity of patients suffering from laryngeal cancer in the Lublin macro-region in the years 1991-95 was carried out. Morbidity rates in the population in consecutive years of investigated 5-year age groups were examined. In clinical investigations the conditions of clinical advancement of the disease in particular organs was determined and environmental factors and occupation were also revealed.

[Epidemiologic and clinical investigations of patients suffering from laryngeal neoplasms in the Lublin region in the years 1991-1994]. / Badania epidemiologiczne i kliniczne chorujacych na raka krtani w makroregionie lubelskim w latach 1991-1994.

Investigations of larynx cancer rate of Lublin population were carried out in the years 1991-1994. Factors of the community rates in each year and in five-years age group were determined. 681 suffering people were examined clinically. The clinical stage and degree of organ involvement were appointed.

Powdered diatrizoic acid for radiography of the respiratory tract. Part II. Clinical application.

The diagnostic and clinical value of 41 examinations using insufflation and/or inhalation of powdered diatrizoic acid for tracheobronchography, tracheography, laryngography, nasopharyngography, and sinusography was investigated in 35 patients. Diatrizoic acid was found to be useful when applied by insufflation for demonstration of the nasopharynx, trachea and greater bronchi, especially in patients with airway stenosis and low pulmonary reserve. Double contrast images were obtained with good demonstration of anatomic details and adequate diagnostic value. Visualization of the peripheral bronchi by insufflation was satisfactory only when excessive secretions were not present. The inhalation method was adequate only for visualization of the trachea and main bronchi. The method was found to be safe since diatrizoic acid produced no toxic, allergic or febrile reactions and was given in relatively small amounts without impairment of respiratory function.

[Use of computerized tomography in topographic diagnosis of salivary gland tumors]. / Zastosowanie tomografii komputerowej w ocenie topograficznej guzów slinianek.

In the radiologic assessment of extension tumors of parotid glands CT method was used and for comparative purposes sialography was performed. In comparative analysis there was assessed CT method and its usefulness in the preoperative assessment of tumor extension.