[Indicators of arterial blood pressure during hormonal contraception]. / Pokazeteli arterial'nogo davleniia pri gormonal'noi kontratseptsii.

PIP: The effect of oral contraceptives (OCs) on changes in arterial pressure (AP) was studied in 160 healthy women, 22-35 years of age, with ovulatory menstrual cycles. They took Ovidan and Non-ovlon for 12 months to prevent unwanted pregnancy. These steroidal preparations contain equal doses (.05 mg) of ethinyl estradiol and different doses of gestagenic components: .25 mg of levonorgestrel in Ovidan and 1 mg of norethisterone acetate in Non-ovlon. Measurements of AP parameters were taken with a mercury sphygmomanometer, and complications caused by OCs were recorded. Results were processed by the usual methods of variational statistics. With Ovidan, a significant increase (p .05) in systolic and diastolic AP was recorded after 3 and 6 months. Systolic and diastolic APs exceeded the initial levels by 7 and 6 mm Hg, respectively. Non-ovlon caused a less pronounced effect; a significant increase (p .05) of systolic and diastolic AP was recorded during the 12th month of contraception only. Thus, the results indicate that OCs can cause an increase in AP, and the gestagenic component increases the risk of hypertension. Levonorgestrel causes a more marked effect than norethisterone. Periodic AP measurements (every 3 months) are recommended for women using OCs. In cases of a steady increase in AP, use of this contraceptive method should be terminated.^ieng

[Systemic changes during the use of hormonal contraceptives]. / Izuchenie sistemnykh izmenenii pri primenenii gormonal'nykh kontratseptivov.

PIP: Systemic changes in the female were investigated before and during treatment with the combined oral contraceptives Ovidon and Rigevidon. The latter compound, with its estrogen/gestagen component reduced by 1/3 as compared to Ovidon, was shown to be less frequently associated with gastrointestinal disorders, headaches, weight changes, and produce smaller systemic changes. (author's modified)^ieng