1.
Bull Exp Biol Med
; 143(3): 308-11, 2007 Mar.
Article
in English
| MEDLINE
| ID: mdl-18225749
ABSTRACT
Immunohistochemical study revealed overexpression of prolactin receptors in central and peripheral cells of intrahepatic grafts from H27 rat hepatoma without changes in compartmentalization compared to hepatocytes of intact animals. Experiments with gonadectomized animals showed that the hormonal regulation of prolactin receptors in both types of tumor cells does not differ from that in normal liver cells (positive estrogen-dependent regulation and negative androgen-dependent regulation).