[Changes in Na, K-ATPase activity following adrenoreceptor blockade]. / Izmenenie aktivnosti Na, K-ATFazy pri blokade adrenoretseptorov.

A regulatory factor released from the effector cell during blockade of postsynaptic alpha- and beta-adrenoreceptors with phentolamine and propranolol (5 X 10(7)-1 X 10(-6) M) and activating norepinephrine neuronal uptake and synthesis, was shown to activate, Na, K-ATPase of the rat isolated organs as well as the preparation of partly purified Na, K-ATPase extracted from the rat brain. Ouabain (1 X 10(-3) M) eliminated completely the activating effect of the regulatory factor on the ATPase.

[Reverse transsynaptic regulation of noradrenaline-H3 uptake in chronic sympathetic denervation]. / Obratnaia transsinapticheskaia reguliatsiia zakhvata noradrenalina-H3 pri khronicheskoi desimpatizatsii.

A change in the functional state of adrenoreceptors in conditions of chronic sympathectomy with guanethidine produces constant spontaneous release of chemical factors regulating the intensity of neuronal uptake of noradrenaline-H3 by an adrenergic neuron. In the first two months when adrenoreceptors experience constant deficit of excitation, the factors are released increasing by half the neuronal uptake of noradrenaline-H3 in atrium and v. deferens. Some increase of NA concentration in peripheral organs during the 3rd month seemingly creates conditions providing for constant activation of sensitized adrenoreceptors which results in the release of factors inhibiting the rate of NA--H3 uptake in atrium by 65%, in v. deferens by 38%. The release from effector cell of chemical agents regulating the intensity of neuronal NA uptake, is one of the local peripheral mechanisms regulating the adrenergic transmitter process.

[Effect of prednisolone on 3H-catecholamine synthesis in the adrenals of physically fatigued rats]. / Deistvie prednizolona na sintez 3H-katekholaminov v nadpochechnikakh krys pri fizicheskom utomlenii.

The effect of prednisolone on the synthesis of 3H-catecholamines by the adrenals of control and rats swimming for 8 hours was studied in experiments in vitro with the use of 3H-thyroxine as precursor. It was shown that in swimming rats, the synthesis of 3H-noradrenaline and 3H-adrenaline is inhibited by 25%, while the synthesis of 3H-dopamine remains unchanged. Addition of prednisolone to the incubation medium does not affect the rate of 3H-catecholamine synthesis by the adrenals of intact rats. Addition of prednisolone to the adrenals of swimming rats leads to the stimulation of the synthesis of 3H-noradrenaline and 3H-adrenaline by 72%, while the synthesis of 3H-dopamine gets stimulated by 56% relative to the synthesis rate of 3H-catecholamines during swimming. In the latter case the rate of 3H-catecholamine synthesis significantly exceeds the control level.

[Effect of desympathization on thrombocyte aggregation capacity and the blood clotting potential of rats]. / Vliianie desimpatizatsii na agregatsionnuiu sposobnost' trombotsitov i koaguliatsionnyi potentsial krovi u krys.

It was shown that platelet aggregation in partially (with stellate ganglia containing 25% neurons of normal amount) and completely (0,5% neurons) sympathectomized rats was significantly lower than in intact animals. Concurrently the blood coagulation system of sympathectomized rats was hyperactive. The reasons for sympathectomy-induced changes seems likely to be elevated adrenalin blood concentration in such rats.