[Local application of recombinant activated factor VII for massive surgical bleeding]. / Lokal'noe primenenie rekombinantnogo aktivirovannogo faktora svertyvaniya krovi VII dlya ostanovki massivnogo operatsionnogo krovotecheniya.

The authors report resection of anaplastic convexital meningioma in a middle-aged woman complicated by expected massive blood loss. The most intense bleeding occurred at the final stage of resection and it was impossible to stop it with traditional approaches. The surgeon pressed a standard tachocomb plate moistened with a diluted solution of recombinant activated factor VII (coagil, Russia) to the most bleeding area for 5 minutes. Subsequently, surgeon replaced finger pressure with a permanent napkin. Hemostatic effect of recombinant activated factor VII following its systemic administration is well known and convincingly proven in many surgical areas including neurosurgery. However, we do not know any descriptions of its local application in neurosurgical patients.

[Brain tissue relaxation in craniotomy: a modern view of the perennial problem]. / Relaksatsiia tkani mozga pri kraniotomii: sovremennyi vzgliad na vechnuiu problemu.

Intraoperative relaxation of brain tissue is one of the important factors affecting the quality and successful outcome of neurosurgical interventions. Despite many clinical studies on the problem of brain bulging, many issues remain not fully resolved. First of all, these are safety aspects of the preventive and therapeutic use of various strategies to fight this phenomenon, development of indications for introduction of hyperosmotic solutions, and use of hyperventilation or lifting of the head end of the operating table.