ABSTRACT
We studied specific features of erythrocyte membrane response to short-term occlusion of the brachial artery in patients with cardiovascular pathology. Under ischemic conditions, processes of sorption were primarily intensified in patients with effort angina and processes of hemoglobin binding with erythrocyte membrane predominated in patients with essential hypertension. These changes in the cell membrane were related to modulation of aggregation properties of erythrocytes (in patients with angina) and plasminogen activity (in patients with essential hypertension). They can also be associated with changes in glucose levels (effort angina) and uric acid (essential hypertension) whose effects can be significantly modified by other endogenous factors.
Subject(s)
Angina, Stable/blood , Coronary Disease/blood , Erythrocyte Membrane/physiology , Adsorption , Adult , Arm/blood supply , Blood Viscosity , Brachial Artery , Constriction , Fibrinogen/analysis , Hemoglobins/analysis , Humans , Ischemia/etiology , Lipids/blood , Male , Malondialdehyde/blood , Middle Aged , Nucleotides/blood , Plasminogen/analysis , Platelet Adhesiveness , von Willebrand Factor/analysisABSTRACT
We present the results of comparative analysis of functional and morphological changes in the liver of animals with experimental CCl(4)-induced hepatitis under conditions of transplantation of neonatal liver cells and nuclei. It was found that transplantation of neonatal liver cell nuclei in acute toxic hepatitis provides better functional and structural state of the target organ.
