1.
Aquat Toxicol
; 58(3-4): 131-6, 2002 Aug.
Article
in English
| MEDLINE
| ID: mdl-12007869
ABSTRACT
Effect of copper ions on lipid matrix organization of synaptosomal membrane of the marine fish Theragra chalcogramma was investigated. It was demonstrated that interaction of copper ions with these membrane stimulated the process of lipid peroxidation and caused changes in the transbilayer distribution of aminophospholipids. Accessibility of phosphatidylethanolamine was increased more than twice, and of phosphatidylserine more than ten times, that can be explained by changes in asymmetrical structure of lipid matrix of synaptosomal membrane. We suggested, that the main mechanism of copper-stimulated damage in transbilayer organization of the membrane is oxidation of membrane protein sulfhydryl groups.
Subject(s)
Copper/toxicity , Lipid Peroxidation/drug effects , Phosphatidylethanolamines/metabolism , Phosphatidylserines/metabolism , Synaptic Membranes/drug effects , Synaptosomes/metabolism , Animals , Fishes , In Vitro Techniques , Kinetics , Membrane Lipids/chemistry , Membrane Lipids/metabolism , Oxidation-Reduction/drug effects , Phosphatidylethanolamines/chemistry , Phosphatidylserines/chemistry , Sulfhydryl Compounds/chemistry , Sulfhydryl Compounds/metabolism , Synaptic Membranes/chemistry , Synaptic Membranes/metabolism , Synaptosomes/chemistry , Synaptosomes/drug effects
2.
Farmatsiia
; 27(5): 50-2, 1978.
Article
in Russian
| MEDLINE
| ID: mdl-700186
3.
Veterinariia
; (8): 85-7, 1976 Aug.
Article
in Russian
| MEDLINE
| ID: mdl-1027219