[The formation of endocrinology in the ancient times].

The formation of endocrinology as an independent medical discipline was preceded by the accumulation of medical experience during many centuries. The medicine of the ancient times was developing on the basis of continuity according to the basic principle «relata refero¼ (I tell what I have been told). Medicine and pharmacy in the countries of the ancient world had many similarities, but at the same time each civilization had its own geographical, cultural and historical particularities. The pathology of the thyroid was among the most studied pathologies in Ancient world. There are frequent mentions of the endemic goiter in the works of doctors from Ancient China, Ancient India and Ancient Greece.Although the link between iodine and the thyroid was not known, algae and dried sea sponges were using for treating swollen neck.There are many descriptions of neuroendocrine pathologies in historical sources, for example the Bible describes gigantism and the Talmud - hypoprolactinaemia.Special attention was paid to the study of diabetes mellitus, although the pathogenesis and treatment of the disease remained unknown until the 20th century.

[Comparative impact analysis of risk factors on the course and outcomes of pregnancy with gestational diabetes mellitus].

BACKGROUND: The increasing prevalence of gestational diabetes mellitus (GDM), the high probability of unfavorable pregnancy outcomes for the mother and the fetus, as well as a number of long-term consequences in GDM are a serious medical and social problem and require the need for its prevention by correcting risk factors, timely diagnosis and effective treatment. AIM: Analysis of risk factors for the development of gestational diabetes mellitus (GDM), the relationship between GDM, the course and outcomes of pregnancy. MATERIALS AND METHODS: Retrospective analysis of 79 case histories of patients with confirmed GDM in the period from 2015 to 2017. RESULTS: In the structure of risk factors for mother and fetus, age over 30 years (73.1%), burdened heredity for type 2 diabetes mellitus (T2DM) (30.8%), mother's pre-pregnancy body mass index (BMI) (overweight / obesity (26.9%)) had the greatest impact. Among the complications of pregnancy, the most common was the caesarean section (47.4%). The incidence of other complications (macrosomia (9%), premature birth (7.7%), congenital malformations of the fetus (5.1%), preeclampsia (5.1%) was lower than the average frequency of these complications in GDM, described in the literature. Nevertheless, it is 1.5-2 times higher than the average population indicators. In the course of statistical analysis of the data it was revealed, that the higher the mother's pre-pregnancy BMI, the lower the Apgar score for the first minute in the newborn. CONCLUSION: Women with GDM require intensive monitoring of the course of pregnancy and timely hospitalization for planned delivery, and the provision of competent obstetric benefits.