The enzymatic studies of the liver in acute experimental pancreatitis in dogs treated with prostacyclin (PGI2).

The liver affection in acute experimental pancreatitis (AEP) could be reflected by changes of enzymatic activity in the liver and in serum. The histoenzymatic studies of the liver of dogs with AEP of different severity and time of duration induced according to Elliott's method were performed and the constellation of serum enzymatic activities considering treatment with prostacyclin was estimated. The histoenzymatic reactions on succinic dehydrogenase, lactic dehydrogenase and alkaline phosphatase were depressed with progression of time and severity of AEP. In contrast, the reaction on acid phosphatase was augmented at the same time. Serum AspAT, AlAT and alkaline phosphatase were augmented in the later phase of AEP, but acid phosphatase and beta-glucuronidase were not significantly changed. The treatment with PGI2 limited both histoenzymatic reactions and alterations of serum enzymatic activities. These results support the significance of changes in enzymatic activities in the course of liver reaction on pancreatogenic noxa during acute pancreatitis, and suggest the protective effect of PGI2 against liver injury in this disease.

[Stromal sarcoma--a contribution to the theory on the histoclinical aspects of neoplasms]. / Ginekologia i poloznictwo.

The authors report histological and clinical analysis of 7 patients with malignant proliferation of the stromal colls in the endometrium. In 3 patients the histological pattern differed form that in the remaining cases in a greater number of cell divisions and higher grade of cell atypia. Despite this, the clinical pattern was similar in nearly all cases. The reported material cannot support the hypothesis of two forms of the disease: stromal sarcoma and stromatosis. Both these diagnoses carry a poor prognosis.

[Results of treatment of patients with adenoacanthoma and mixed endometrial carcinoma]. / Wyniki leczenia chorych z rozpoznaniem adenoacanthoma i carcinoma mixtum endometrii.

The authors analysed 348 patients with endometrial carcinoma taking into account the diagnoses of adenocarcinoma, adenoacanthoma and mixed carcinoma. In evaluating these patients the degree of histological malignancy, extent of malignant infiltration in the uterus were considered, development of endometrial carcinoma in different phases of life of the women was studied, the hormonal profile and the methods of treatment were analysed. It is stressed that the prognosis of mixed carcinoma is worse than that of adenoacanthoma.