[Prenatal and postnatal prevention of iodine deficiency in the first year of life]. / Prenatal'naia i postnatal'naia profilaktika iodnogo defitsita u detei pervogo godi zhizni.

A total of 260 females were studied in an iodine-deficient regions in different periods of gestation. Among them, 123 females were examined during pregnancy and within 3 months of lactation. Iodine deficiency during pregnancy was shown to form a high risk for diseases in both a child and a mother. There is an increased risk for severe complications of pregnancy and labor, for decreased weight and height, and for the worse status of a fetus and a baby of the first year of life. The use of iodine-containing drugs (100 micrograms iodine a day) is highly effective.

[Prevalence of somatic diseases in children with endemic goiter]. / Rasprostranennost' somaticheskikh zabolevanii u detei s éndemicheskim zobom.

A total of 1649 children aged 0 to 16 years were examined in the Khvalynsk district of the Saratov region endemic for goiter. Age-specific features of prevalence of goiter and chronic somatic diseases were studied. Goiter was found to form starting from the first years of life, with its morbidity peaks observed at the age of 3, 5, 7, and 12. Disease incidence in children with endemic goiter was found to be higher than in those without thyroid abnormalities.

[Characteristics of sexual maturation of girls with juvenile hyperplasia of the thyroid gland]. / Osobennosti polovogo sozrevaniia devochek pri iuvenil'noi giperplazii shchitovidnoi zhelezy.

Overall 69 girls with stage II and III juvenile hyperplasia of the thyroid without any clinical signs of pubertal abnormality were examined. Of these, 2/3 had the normal content of circulating thyroid and thyrotropic hormones in the blood serum. In prepubertal girls, the age-associated basal concentrations of gonadotropins and sexual steroid were discovered, whereas in puberty, there was a significant increase of the content of luteinizing hormone, prolactin, estradiol (a two-fold increase) and progesterone (a ten-fold increase) in the second phase of the menstrual cycle, which attested to its ovulatory nature. In 1/3 of the girls, subclinical hypothyrosis with a significant rise of the level of thyrotropic hormone associated with normal or lowered concentrations of triiodothyronine or thyroxine was diagnosed. In addition, the metabolic markers of the discoordination of the hypothalamo-hypophyseal-gonadal system were revealed: an increase of the content of luteinizing hormone and prolactin associated with the low levels of estradiol and progesterone.