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[Protection from the effect of cadmium chloride of human cells, pretreated with vitamins, interferon and preliminary low-dose gamma irradiation]. / Zashchita ot deistviia khloristogo kadmiia kletok cheloveka, predobrabotannykh vitaminami, interferonom i predvaritel'nym gamma-oblucheniem v malykh dozakh.

Kusainova, K A; Vasil'eva, I M; Chekova, V V; Akhmatullina, N B; Zasukhina, G D.

Dokl Akad Nauk SSSR ; 322(2): 398-401, 1992.

Article in Russian | MEDLINE | ID: mdl-1376229

Subject(s)

Cadmium/toxicity , Chlorides/toxicity , DNA/drug effects , Interferons/pharmacology , Vitamins/pharmacology , Antimutagenic Agents , Cadmium/antagonists & inhibitors , Cadmium Chloride , Chlorides/antagonists & inhibitors , DNA/radiation effects , DNA Damage , DNA Repair/drug effects , Humans , Lymphocytes/drug effects , Lymphocytes/radiation effects , Radiation-Protective Agents/pharmacology

[The stimulation of DNA repair in workers in contact with cadmium chloride by vitamins used as antimutagens]. / Stimuliatsiia reparatsii DNK u rabochikh, kontaktiruiushchikh s khloristym kadmiem, vitaminami, ispol'zuemymi v kachestve antimutagenov.

Vasil'eva, I M; Chekova, V V; L'vova, G N; Kusainova, K A; Chopikashvili, L V; Zasukhina, G D.

Dokl Akad Nauk SSSR ; 318(2): 441-5, 1991.

Article in Russian | MEDLINE | ID: mdl-1909950

Subject(s)

Ascorbic Acid/therapeutic use , Cadmium/adverse effects , DNA Damage , DNA Repair/drug effects , DNA, Single-Stranded/drug effects , DNA/drug effects , Mutation/drug effects , Occupational Exposure/adverse effects , Vitamin A/therapeutic use , 4-Nitroquinoline-1-oxide/pharmacology , Cadmium Chloride , Cells, Cultured/drug effects , Cells, Cultured/metabolism , Cells, Cultured/radiation effects , DNA/biosynthesis , DNA/radiation effects , DNA Repair/radiation effects , DNA, Single-Stranded/biosynthesis , DNA, Single-Stranded/radiation effects , Drug Evaluation, Preclinical , Humans , Lymphocytes/drug effects , Lymphocytes/metabolism , Lymphocytes/radiation effects , Mutation/radiation effects , Stimulation, Chemical , Ultraviolet Rays

[Mechanisms of disrupting DNA repair in human cells. IV. Interferon protects DNA of noninfected and chronically infected human cells from damage caused by cadmium chloride]. / Mekhanizmy narushenii reparatsii DNK v kletkakh chelovka. Soobshchenie IV. Interferon zashchishchaet DNK neinfitsirovannykh i khronicheski infitsirovannykh kletok cheloveka ot povrezhdenii, vyzyvaemykh khloristym kadmiem.

Vasil'eva, I M; Kolonina, I V; Kusainova, K A; Bogomolova, N N; Zasukhina, G D.

Genetika ; 25(10): 1872-7, 1989 Oct.

Article in Russian | MEDLINE | ID: mdl-2482823

ABSTRACT

The protective activity of interferon on the cadmium chloride-treated human cells (Hep-2), infected chronically with meals virus and uninfected, was studied. It was found that cadmium chloride induced the formation of partially non-repairable DNA lesions. Decrease in cell repair activity was observed in the cells chronically infected with virus. Pretreatment of cells with interferon protected cell DNA from formation of DNA breaks and caused more effective resynthesis of DNA breaks.

Subject(s)

Cadmium/toxicity , DNA Damage , DNA Repair , Interferons/pharmacology , Mutagens , Cadmium Chloride , DNA/drug effects , Humans , Measles virus/isolation & purification , Tumor Cells, Cultured/drug effects , Tumor Cells, Cultured/microbiology

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