[An immunochemical analysis of the function of the hemato-encephalic barrier in acute fetal hypoxia and asphyxia neonatorum]. / Immunokhimicheskii analiz sostoianiia gematoéntsefalicheskogo bar'era pri ostroi gipoksii plodov i asfiksii novorozhdennykh.

The neurospecific protein alpha 1-globulin has been assayed in serum in order to evaluate the blood-brain barrier in newborns with acute intrapartum hypoxia. The study involved 35 term newborns with birth asphyxia of variable severity. The alpha 1-globulin levels correlated with severity of condition at birth, duration of intrauterine exposure to hypoxia and the presence of obstetric complications and clinical severity of cerebral circulatory disorders. A normal early adaptation and effective therapy reduced serum alpha 1-globulin levels 4-8-fold on the 3rd postnatal day and 6-16-fold on the 5th day. Deterioration of neurological symptoms was parallelled by a significant increase in protein levels (to 6400 ng/ml) at day 5. This evidence may confirm the fact that permeability of the blood-brain barrier is impaired by intrapartum hypoxia.

[The mechanism of the disorder in the cytoarchitectonics and structural organization of the erythrocyte membranes in gestoses]. / Mekhanizm narusheniia tsitoarkhitektoniki i strukturnoi organizatsii éritrotsitarnykh membran pri gestozakh.

Mechanisms underlying gestosis-associated changes in architectonics of the erythrocytes and structural pattern of their membranes have been identified. The changes were related to the rates of lipid peroxidation in the erythrocyte membranes. Phospholipase A2 activation and tissue hypoxia were identified as important determinants of cell membrane abnormalities in progressive and moderate-to-severe nephropathy.

[Antioxidant therapy in the complex treatment of late pregnancy toxemia]. / Antioksidantnaia terapiia v kompleksnom lechenii pozdnikh toksikozov beremennykh.

Lipid oxidation blood levels, activity of serum antioxidative system and erythrocytic membranes were investigated in the time-course of treatment of 145 pregnant females with nephropathies of various severity. More pronounced improvement of the parameters studied and elimination of late gestosis symptoms were revealed in the treatment with antioxidative preparations, lipostabil and solcoseryl. Regardless of treatment pattern in pregnancies complicated by severe nephropathy there were improvements noted, as a rule, in presence of pharmacological management but after its withdrawal the signs of the diseases relapsed (2-6 days after). Continuation of pregnancy up to the terms when the fetus was expected to be born viable was considered as the main target of the aforementioned treatment.