ABSTRACT
The paper presents an evaluation of the results of surgical and combined treatment received by 961 patients at the Center's Clinics within 28 years. The analysis was based on 3 protocols of prospective randomized study. It dealt with assessment of the end results of surgical and combined treatment for operable rectal cancer using one preoperative hyperfractonated STD of 5-25 Gy. That was combined with local microwave hyperthermia and two radio modifiers--local microwave hyperthermia+intrarectal administration of a preparation containing metronidazolum. Due to the latter factor, the rate of 3-year relapse-free survival rose considerably. Also, loco-regional and distant metastasis incidence was cut down due to superior ablasticity of surgery.
Subject(s)
Rectal Neoplasms/mortality , Rectal Neoplasms/therapy , Combined Modality Therapy , Disease-Free Survival , Female , Humans , Male , Prospective Studies , Randomized Controlled Trials as Topic , Retrospective Studies , Survival RateABSTRACT
Active surgical intervention in patients with kidney carcinoma and metastases in the bones helped in prolonging the life of previously doomed patients for several years. Of course, we are far from the idea that such tactics is justified in all patients. An individual approach is necessary. The fundamentals of successful treatment is thorough diagnosis. The extent of the neoplastic process cannot always be determined, errors are often made in establishing the diagnosis, which leads to faulty choice of the therapeutic tactics.
Subject(s)
Bone Neoplasms/secondary , Kidney Neoplasms/surgery , Bone Neoplasms/diagnosis , Bone Neoplasms/mortality , Bone Neoplasms/surgery , Combined Modality Therapy , Humans , Kidney Neoplasms/mortality , Nephrectomy , Postoperative Care , Time FactorsABSTRACT
A total of 120 cases with Stages I (n = 32) and IIa (n = 88) mammary carcinoma who later developed metastases to the bones are analyzed. The authors come to a conclusion that the time course of the metastases development directly depends on the tumor process stage. Postoperative thiophosphamide chemotherapy is the most effective method for the prevention of metastases to the bones; postoperative radiotherapy is conducive to a most rapid dissemination of the metastases in the bones.
Subject(s)
Bone Neoplasms/secondary , Breast Neoplasms/pathology , Bone Neoplasms/etiology , Bone Neoplasms/prevention & control , Breast Neoplasms/surgery , Female , Humans , Mastectomy, Radical , Neoplasm Staging , Postoperative Care , Radiotherapy/adverse effects , Thiotepa/therapeutic use , Time FactorsABSTRACT
The effect of adjuvant chemotherapy on survival and prognosis in osteogenic sarcoma versus basic clinico-roentgenomorphological characteristics of tumor was studied in 108 cases. Prognosis was found to depend on patient's age, site and size of tumor, but mainly on the roentgeno-morphological pattern of the latter. Osteolytic form appeared to have a better course in cases of adjuvant chemotherapy. This was matched by osteoplastic form requiring surgical treatment only. The results suggest a strictly differentiated approach to selection of treatment modality, particularly in cases of post-operative chemotherapy.