ABSTRACT
The efficiency of bilidase (hyaluronidase preparation) was studied in guinea pigs with experimental postburn cicatrices. Bilidase promoted normalization of the structure and histochemical picture of new cicatricial tissue. The drug can be used for the treatment of hypertrophic postburn cicatrices.
Subject(s)
Burns/complications , Cicatrix, Hypertrophic/drug therapy , Hyaluronoglucosaminidase/therapeutic use , Skin/injuries , Animals , Cicatrix, Hypertrophic/etiology , Guinea Pigs , Skin/pathologyABSTRACT
Histochemical and immunohistochemical methods were used to examine 29 malignant tumors (18 lobular and 11 invasive carcinomas) and 34 fibroadenomas of the mammary gland (MG). APUD cells containing serotonin, melatonin, and beta-endorphine were shown to be present in the duct epithelium of the normal MG and its pericanalicular fibroadenoma. APUD cells were detected in 21 of the 29 malignant tumours of MG. Hormonal differences of APUD cells were found in poorly and well differentiated carcinomas: the former contained serotonin, melatonin, and beta-endorphine (inhibitors of proliferation), the latter--insulin and adrenocorticotropic hormone (stimulators of cell division). Such differences in the endocrine function of MG malignant tumors are likely to be significant in the clinical course and determination of prognosis for carcinomas of various differentiation.
Subject(s)
APUD Cells/pathology , Adenofibroma/pathology , Breast Neoplasms/pathology , Carcinoma/pathology , Fibrocystic Breast Disease/pathology , APUD Cells/analysis , Adrenocorticotropic Hormone/analysis , Humans , Immunohistochemistry , Melatonin/analysis , Serotonin/analysis , beta-Endorphin/analysisABSTRACT
It has been concluded from the studies on the activity and location of ATPase and 5-nucleotidase in mammary and gastric tumours that some neoplasms of the mammary gland and stomach showing a high ATPase activity are histochemically related, in the former case, to the lobular myoepithelium and in the latter case, to non-differentiated cells of gastric glands which acquired a capacity for intestinal metaplasia and preserved it in the course of malignant transformation. No essential changes have been recorded in the activity of 5-nucleotidase, depending on the tumour histologic structure and degree of its maturity.
