ABSTRACT
Pathogenic Candida and infections caused by those species are now considered as a serious threat to public health. The treatment of candidiasis is significantly complicated by the increasing resistance of pathogenic strains to current treatments and the stagnant development of new antimycotic drugs. Many species, such as Candida auris, have a wide range of resistance mechanisms. Among the currently used synthetic and semi-synthetic antifungal drugs, the most effective are azoles, echinocandins, polyenes, nucleotide analogs, and their combinations. However, the use of probiotic microorganisms and/or the compounds they produce is quite promising, although underestimated by modern pharmacology, to control the spread of pathogenic Candida species.
Subject(s)
Antifungal Agents/pharmacology , Candida/drug effects , Drug Resistance, Fungal , Probiotics , Candida aurisABSTRACT
Development of sustainable bio-based materials for removal of toxic contaminants from water is a high priority goal. Novel bio-based binary and ternary copolymers with enhanced ion-exchange, adsorption and antibacterial properties were obtained by using plant biomass-derived diallyl esters of furandicarboxylic acid (FDCA) as crosslinking agents and easily available vinyl monomers. The synthesized copolymer materials showed higher sorption capacities for NiII , CoII and CuII compared to the commercial ion-exchange resins, and they maintained their high metal adsorption capacities for over 10â cycles of regeneration. The synthesized copolymer gels containing 1-5â wt % of the crosslinker showed excellent water absorption capacities. The synthesized copolymers with 1 % crosslinker content showed swelling ratios high enough to also act as moisture absorbents. Synthesized copolymers with crosslinker content of 10â wt % performed as contact-active antibacterials by inhibiting the growth of Gram-positive (S.â aureus) and Gram-negative bacteria (E.â coli, K.â pneumonia) in suspension tests.
