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1.
J Nippon Med Sch ; 80(3): 184-91, 2013.
Article in English | MEDLINE | ID: mdl-23832402

ABSTRACT

INTRODUCTION: The Utstein-style guidelines have been used in various countries around the world, because they are suitable for evaluating regional emergency medical systems (EMSs) for patients who have an out-of-hospital cardiac arrest (OHCA). This report examined the present status of treating OHCA in Saga Prefecture and examined policies that can contribute to improving the rate of the return of spontaneous circulation (ROSC). METHODS: This study examined 800 cases of OHCA by means of the Utstein-style guidelines submitted for medical control verification by firefighting organizations in Saga Prefecture from July 1, 2010, to June 30, 2011. The firefighting organizations were divided into 5 areas (A-E) according to each medical classification. The 5 areas were compared in terms of the ROSC rate and background factors (patient age and sex, cardiac arrest cause, place, witnesses, initial electrocardiogram [ECG], hospital ECG, prehospital medical treatment, transfer time, oral instruction, and bystander cardiopulmonary resuscitation [CPR]). RESULTS: The ROSC rate was significantly lower in areas D (24.2%) and E (26.8%). Age, sex, cardiac arrest cause, place, witnesses, initial ECG, hospital ECG, shock, and adrenaline administration did not differ significantly among the 5 areas. The response time was significantly shorter in areas A (8: 25), D (8: 07), and E (8: 12). There were significantly fewer examples of oral CPR instruction in area E (42.1%), and there were fewer examples of CPR in areas A (44.0%), D (41.9%), and E (37.9%). CPR was performed by lay person in approximately 70% of the cases in which oral instructions were provided, but it was not performed in 90% of cases in which no oral instructions were provided. CONCLUSIONS: The Utstein-style guidelines were used to clarify differences in the ROSC rate in Saga Prefecture, thus making improvements in regional EMSs possible. Improvements in the quality of oral instruction and a reexamination of the oral instruction manual are expected to improve the ROSC rate, in parallel with education in basic life support for lay person and in advanced cardiac life support for medical personnel. In addition, it is important to reaffirm the effectiveness of CPR and encourage the participation of lay person by providing instructions by telephone from an ambulance that is en route to the scene.


Subject(s)
Out-of-Hospital Cardiac Arrest/diagnosis , Out-of-Hospital Cardiac Arrest/epidemiology , Aged , Cardiology/standards , Cardiopulmonary Resuscitation/methods , Emergency Medical Services , Female , Humans , Japan/epidemiology , Male , Middle Aged , Retrospective Studies
2.
Gen Thorac Cardiovasc Surg ; 60(1): 31-5, 2012 Jan.
Article in English | MEDLINE | ID: mdl-22237736

ABSTRACT

PURPOSE: This study investigated the relation between the cause of blunt cardiac injury and areas of damage. For the purpose of injury prevention, we also examined traffic accident cases in a micro study using engineering-based medicine. METHODS: Among the 2673 patients transported to our facility within the 15-month period from February 2009 to April 2010, there were 12 cases of cardiac perforation. We studied these cases anatomically to evaluate the morphology of the damaged cardiac areas. We conducted a detailed micro-study in two cases regarding the circumstances surrounding the traffic accident and the vehicular damage. RESULTS: Subjects were nine men (mean age 64 years). The mean Injury Severity Score was 54.0 ± 19.6, and the probability of survival was 0.147. The actual survival rate was 16.7% (2 survivors, 10 deaths). Lesion sites in the 12 cases (21 sites in total) were the right atrium in 8 cases, superior and inferior vena cava in 5 cases, right ventricle in 4 cases, pulmonary artery and left atrium in 1 case each, and pulmonary vein in 2 cases, excluding the left ventricle and ascending aorta. In three cases, the aortic isthmus was also injured. CONCLUSION: Blunt cardiac injury was more common on the right side chamber. The survival rate was extremely close to the calculated survival probability. Proper seatbelt usage is important for the prevention of blunt cardiac injury due to traffic accidents. Increased severity of injury may be associated with accidents involving light motor vehicles.


Subject(s)
Accidents, Traffic , Heart Injuries/diagnosis , Wounds, Nonpenetrating/diagnosis , Accidents, Traffic/mortality , Accidents, Traffic/prevention & control , Aged , Aged, 80 and over , Female , Heart Atria/injuries , Heart Atria/pathology , Heart Injuries/etiology , Heart Injuries/mortality , Heart Injuries/pathology , Heart Injuries/prevention & control , Heart Ventricles/injuries , Heart Ventricles/pathology , Humans , Japan/epidemiology , Male , Middle Aged , Pulmonary Artery/injuries , Pulmonary Artery/pathology , Pulmonary Veins/injuries , Pulmonary Veins/pathology , Seat Belts , Severity of Illness Index , Survival Rate , Vena Cava, Inferior/injuries , Vena Cava, Inferior/pathology , Vena Cava, Superior/injuries , Vena Cava, Superior/pathology , Wounds, Nonpenetrating/etiology , Wounds, Nonpenetrating/mortality , Wounds, Nonpenetrating/pathology , Wounds, Nonpenetrating/prevention & control
3.
J Nippon Med Sch ; 77(4): 218-20, 2010 Aug.
Article in English | MEDLINE | ID: mdl-20818141

ABSTRACT

We report a rare case of commotio cordis caused by traffic injury. The patient was a 60-year-old female driver who suffered severe steering wheel impact to the chest during a head-on collision in which her car overturned. She had no history of cardiac disease. Emergency medical services arrived at the scene within 12 minutes of the accident. Evidence of ventricular fibrillation led the paramedics to carry out immediate defibrillation with an automated external defibrillator. Restoration of spontaneous circulation was confirmed within 2 minutes, along with establishment of sinus rhythm and normal wave form on electrocardiography. The patient was transported to our hospital in an emergency helicopter. General examination revealed chest bruising, and computed tomography of the chest showed pulmonary contusions; there was no other evidence of critical injury. We performed endotracheal intubation, as the patient had consciousness disturbance, and then initiated hypothermic therapy in the intensive care unit. Meanwhile, the hemodynamics remained stable, and there was no recurrence of arrhythmia. On day 15, the patient's consciousness improved, and she was able to communicate. Two months later, she was transported to another hospital for rehabilitation.


Subject(s)
Accidents, Traffic , Commotio Cordis/etiology , Motor Vehicles , Female , Humans , Middle Aged , Ventricular Fibrillation/complications
4.
J Nippon Med Sch ; 77(3): 138-44, 2010 Jun.
Article in English | MEDLINE | ID: mdl-20610897

ABSTRACT

BACKGROUND: Systemic inflammatory response syndrome (SIRS) is a clinical condition representing the culmination of the activation of a complex network of acute endogenous mediators. MATERIALS AND METHODS: We investigated both the relationship between the results of SIRS assessments in 212 trauma patients at the time of hospital arrival and measures of trauma severity determined using the Injury Severity Score (ISS) and the Revised Trauma Score (RTS). We then considered the possibility of whether this assessment could be used to predict the development of organ dysfunction as a complication in trauma patients after admission. The serum neutrophil elastase (SNE) level was also measured in 47 cases. RESULTS: The cases with SIRS had a significantly higher ISS and a lower RTS. Organ dysfunction occurred in 22 cases, and a significant correlation was noted between the development of organ dysfunction and the presence of SIRS (86.4%; 19 cases/22 cases, p=0.0007) at the time of arrival. The SNE level was significantly higher among the patients who fulfilled the four SIRS criteria than among the other patients (p=0.0301). CONCLUSION: We concluded that the greater the SIRS score at the time of hospital arrival, the greater the anatomical and physiological severity of the trauma patient's condition.


Subject(s)
Leukocyte Elastase/blood , Systemic Inflammatory Response Syndrome/diagnosis , Wounds and Injuries/diagnosis , Aged , Female , Humans , Injury Severity Score , Male , Middle Aged , Patient Admission , Prevalence , Retrospective Studies , Systemic Inflammatory Response Syndrome/epidemiology , Treatment Outcome
5.
J Nippon Med Sch ; 77(3): 155-9, 2010 Jun.
Article in English | MEDLINE | ID: mdl-20610899

ABSTRACT

OBJECTIVE: Deep vein thrombosis (DVT) is a major risk factor for pulmonary thromboembolism (PTE). We carefully selected patients for surgical thrombectomy to treat acute-phase thrombosis and obtained favorable results. METHODS: Over the past 5 years, we have performed surgical thrombectomy via a minimum femoral skin incision in 11 patients. Surgery was considered for patients with persistent phlegmasia cerulea dolens, despite thrombolytic therapy. All of our patients underwent surgery within 14 days of the onset of symptoms. During the operation, the patients were kept in the supine anti-Trendelenburg position to prevent PTE, and general anesthesia was maintained with positive-pressure mechanical ventilation. Blood flow to the inferior vena cava was occluded with a blocking catheter, and thrombectomy was performed with a thrombectomy catheter inserted parallel to the blocking catheter. A cell separator device was used effectively for autologous blood transfusion. To prevent reocclusion and promote collateral perfusion, we constructed an arteriovenous fistula for an iliac venous spur. RESULTS: There were no major postoperative complications, such as PTE or peritoneal bleeding, and no cases of postthrombotic syndrome after an average 38.4 months of follow-up. CONCLUSION: This surgical technique for venous thrombectomy is minimally invasive and safe for Japanese patients; surgical thrombectomy should be considered a treatment option for DVT in Japan.


Subject(s)
Thrombectomy/methods , Venous Thrombosis/surgery , Acute Disease , Adult , Aged , Female , Humans , Japan , Male , Middle Aged , Risk Factors , Surgical Procedures, Operative , Time Factors , Treatment Outcome
6.
Indian J Crit Care Med ; 14(1): 35-9, 2010 Jan.
Article in English | MEDLINE | ID: mdl-20606907

ABSTRACT

BACKGROUND: Septic shock remains a major cause of multiple organ failure and is associated with a high mortality rate. In 1994, direct hemoperfusion using a polymyxin B-immobilized fiber column (PMX; Toray Industries Inc., Tokyo Japan) was developed in Japan and has since been used for the treatment of septic shock arising from endotoxemia. MATERIALS AND METHOD: We treated 36 patients with septic shock using direct hemoperfusion with PMX. The patients were analyzed in two groups based on whether they had undergone surgery prior to DHP-PMX treatment (surgical group: surgical treatment before DHP-PMX, medical group: no surgical treatment). In surgical group, DHP-PMX was started within three hours after the surgical treatment. Various factors were measured before and after DHP-PMX. RESULTS: The mean Acute Physiology and Chronic Health Evaluation (APACHE) II score was 27.4 +/- 8.8, and the mean sepsis-related organ failure assessment (SOFA) score was 11.8 +/- 4.9 before DHP-PMX. The SOFA score was significantly higher (P = 0.0091) and the PaO2/FiO2 ratio (P/F ratio) was significantly lower (P = 0.0037) in medical group than in surgical group prior to DHP-PMX. A chi-square test showed that the survival rate in surgical group was significantly better than in medical group (P = 0.0027). The survival rate of surgical group (84.2%) was judged to be very good because the predicated survival rate based on the APACHE II score (25.0) was only 46.5%. On the other hand, the survival rate of medical group (35.3%) was almost equal to that predicted by the APACHE II score (30.6; predicted survival rate, 27.4%). CONCLUSION: The results of this study suggest the utility of early DHP-PMX in surgical group.

7.
J Nippon Med Sch ; 77(2): 123-5, 2010 Apr.
Article in English | MEDLINE | ID: mdl-20453427

ABSTRACT

We report on a patient with spontaneous rupture of a nonaneurysmal left common iliac artery in whom hemorrhagic shock developed. A 64-year-old woman presented with hemodynamic collapse accompanied by sudden abdominal pain. She was transported to the emergency department. Angiography showed a penetrating atherosclerotic ulcer in the left common iliac artery. Emergency surgery was performed with graft replacement (14 x 7 mm woven Dacron graft). Severe calcification was observed in the left common iliac artery, and an ulcer of the iliac artery was confirmed as the source of hemorrhage. The postoperative course was uneventful, and the patient was discharged on postoperative day 14. We conclude that rupture may occur in patients with severe atherosclerotic change, even in the absence of aneurysm.


Subject(s)
Aortic Diseases/complications , Atherosclerosis/complications , Iliac Artery/pathology , Ulcer/complications , Abdominal Pain/etiology , Aortic Diseases/diagnostic imaging , Aortic Diseases/surgery , Atherosclerosis/diagnostic imaging , Atherosclerosis/surgery , Blood Vessel Prosthesis Implantation , Calcinosis/complications , Calcinosis/pathology , Female , Hematoma/etiology , Humans , Iliac Artery/diagnostic imaging , Iliac Artery/surgery , Middle Aged , Rupture, Spontaneous , Shock, Hemorrhagic/etiology , Tomography, X-Ray Computed , Treatment Outcome , Ulcer/diagnostic imaging , Ulcer/surgery
8.
Yonsei Med J ; 51(3): 354-9, 2010 May.
Article in English | MEDLINE | ID: mdl-20376887

ABSTRACT

PURPOSE: Atrial natriuretic peptide (ANP) has a variety of pharmacologic effects, including natriuresis, diuresis, vasodilatation, and suppression of the reninangiotensin system. A recent study showed that ANP infusion improved hypoxemia and pulmonary hypertension in a lung injury model. On the other hand, the pulse contour cardiac output (PiCCO(TM)) system (Pulsion Medical Systems, Munich, Germany) allows monitoring of the intravascular volume status and may be used to guide volume therapy in severe sepsis and critically ill patients. MATERIALS AND METHODS: We treated 10 pulmonary edema patients without heart disease with human ANP (HANP). The patients were divided into two groups: a group with normal Intrathoracic Blood Volume (ITBV) (900-1100 mL/m(2)) (n = 6), and a group with abnormal ITBV (n = 4), as measured by the PiCCO(TM) device; the extravascular lung water (EVLW) and pulmonary vascular permeability index (PVPI) in the two groups were compared. RESULTS: The average patient age was 63.9 +/- 14.4 years. The normal ITBV group showed significant improvement of the EVLW (before, 16.7 +/- 2.7 mL/kg; after, 10.5 +/- 3.6 mL/kg; p = 0.0020) and PVPI (before, 3.2 +/- 0.3; after, 2.1 +/- 0.7; p = 0.0214) after the treatment. The abnormal ITBV group showed no significant improvement of either the EVLW (before, 16.3 +/- 8.9 mL/kg; after, 18.8 +/- 9.6 mL/kg; p = 0.8387) or PVPI (before, 2.3 +/- 0.8; after, 2.7 +/- 1.3; p = 0.2782) after the treatment. In both groups, the EVLW and PVPI were strongly correlated with the chest X-ray findings. CONCLUSION: We conclude that HANP supplementation may improve the EVLW and PVPI in pulmonary edema patients without heart disease with a normal ITBV. The PiCCO(TM) system seems to be a useful device for the management of pulmonary edema.


Subject(s)
Atrial Natriuretic Factor/therapeutic use , Cardiac Output/drug effects , Cardiac Output/physiology , Monitoring, Physiologic/instrumentation , Pulmonary Edema/drug therapy , Pulmonary Edema/physiopathology , Aged , Atrial Natriuretic Factor/administration & dosage , Female , Humans , Injections, Intravenous , Male , Middle Aged
9.
Indian J Gastroenterol ; 29(1): 34-6, 2010 Jan.
Article in English | MEDLINE | ID: mdl-20373085

ABSTRACT

Infected pancreatic necrosis is a severe complication of acute pancreatitis; this complication is the major cause of death. We used the 'pipe-organ' -like retroperitoneal drainage, which is usually used in the management of open pelvic fracture, successfully in a patient with severe infected pancreatic necrosis. This procedure can avoid gastrointestinal fistula and local bleeding without necessitating surgery.


Subject(s)
Drainage/methods , Pancreatitis, Acute Necrotizing/therapy , Adult , Drainage/instrumentation , Humans , Male , Pancreatitis, Acute Necrotizing/microbiology , Retroperitoneal Space
10.
J Nippon Med Sch ; 77(1): 13-20, 2010 Feb.
Article in English | MEDLINE | ID: mdl-20154453

ABSTRACT

BACKGROUND: Several reports have validated the criteria for damage control surgery (DCS). However, although metabolic acidosis and body temperature can be measured quickly, tests for predicting the severity of coagulopathy require special laboratory equipment and take 15 to 30 minutes. Such delays could be life-threatening for patients requiring DCS. The aim of this study was to establish simplified and practical criteria to enable rapid decision-making regarding the need for DCS. METHODS: Thirty-four consecutive patients with unstable hemodynamics after initial fluid resuscitation who had undergone DCS for severe abdominal or pelvic injuries were retrospectively analyzed. The patients' characteristics, clinical courses, laboratory data, and outcomes were reviewed using the data contained in their medical records. RESULTS: The overall survival rate was 55.9% (survivors group: n=19; nonsurvivors group: n=15), which was similar to the calculated mean probability of survival (Ps=0.5671). At the start of surgery, the systolic blood pressure (SBP) was less than 90 mm Hg in all cases in which surgery failed, and the mean SBP in the nonsurvivors group (69.6 +/- 14.8 mm Hg) was significantly lower than that in the survivors group (93.2 +/- 22.9 mm Hg, p=0.006). Except in two cases, the value of the base excess in the nonsurvivors group was less than -7.5 mmol/L, and the mean base excess (-11.5 +/- 5.3 mmol/L) in the nonsurvivors group was significantly less than that in the survivors group (-5.5 +/- 4.9 mmol/L, p=0.008) at the start of surgery. The core temperature at the start of surgery was less than 35.5 degrees C in all cases in the nonsurvivors group. On the basis of these results, three indicators (SBP less than 90 mm Hg, base excess less than -7.5 mmol/L, and core temperature less than 35.5 degrees C at the start of surgery) were identified. The success rate of DCS in patients who possessed all three indicators (28.6% ) was significantly lower than that in patients who did not possess all three indicators (75.0%; p=0.014). CONCLUSION: Our results indicate that surgeons should decide to perform DCS when only one or two criteria defined in this study are met and should not wait for all three criteria. Although our proposed criteria are not strict and may broaden the indications for DCS, leading to an increase in the number of DCS procedures, saving the lives of patients who have sustained severe torso trauma must be the priority; 'over-triage' may be acceptable in situations where an appropriate decision-making protocol has been followed.


Subject(s)
Abdominal Injuries/surgery , Acidosis/therapy , Blood Coagulation Disorders/therapy , Hypothermia/therapy , Triage/methods , Abdominal Injuries/mortality , Acidosis/mortality , Adult , Aged , Aged, 80 and over , Blood Coagulation Disorders/mortality , Child , Emergency Medical Services/methods , Female , Humans , Hypotension/mortality , Hypotension/therapy , Hypothermia/mortality , Male , Middle Aged , Pelvis/injuries , Resuscitation , Retrospective Studies , Trauma Severity Indices , Young Adult
11.
Indian J Crit Care Med ; 14(4): 175-9, 2010 Oct.
Article in English | MEDLINE | ID: mdl-21572747

ABSTRACT

AIM: As an alternative method for acute blood purification therapy, continuous venovenous hemodiafiltration (CVVHDF) has been reported as an effective clinical treatment for critically ill patients, but the optimal column for performing CVVHDF remains controversial. PATIENTS AND METHODS: We used direct hemoperfusion using a polymyxin B-immobilized fiber column (DHP-PMX) to treat 88 patients with septic shock. To determine the optimal acute blood purification therapy, we subsequently divided the patients into three groups: the first group underwent CVVHDF using a polymethylmethacrylate membrane hemofilter (PMMA) after undergoing DHP-PMX (28 cases), the second group underwent CVVHDF using a polyacrylonitrile membrane hemofilter (PAN) after undergoing DHP-PMX (26 cases), and the third group did not undergo CVVHDF after undergoing DHP-PMX (34 cases). RESULTS: The overall survival rate was 54.5%, and patient outcome was significantly related to the Acute Physiology and Chronic Health Evaluation (APACHE) II score, the sepsis-related organ failure assessment (SOFA) score, and the blood lactic acid value before treatment (all P<0.0001). Only the PMMA-CVVHDF group showed a better outcome (survival rate of 78.6%) compared with the other groups (P = 0.0190). In addition, only the PMMA-CVVHDF group showed a significant improvement in the blood lactic acid level on day 3 (P = 0.0011). CONCLUSION: Our study suggests that the PMX column might be effective during the early phase of septic shock, before a high level of lactic acid is present. Furthermore, a PMMA column might be the most useful column for performing CVVHDF after DHP-PMX treatment, as suggested by the blood lactic acid value.

12.
Resuscitation ; 80(11): 1270-4, 2009 Nov.
Article in English | MEDLINE | ID: mdl-19744764

ABSTRACT

OBJECTIVE: We investigated whether emergency thoracotomy (ET) performed in pre-hospital settings contributed to saving the lives of blunt trauma patients with impending or recent cardiac arrest. METHODS: Eighty-one consecutive cardiac arrest patients with blunt trauma were performed ET before or after arrival at the emergency department (ED). These were reviewed retrospectively and were classified into the following three groups: (1) an emergency field thoracotomy was performed (EFT group, n=34); (2) a doctor dispatched to the scene, but the thoracotomy was performed in the ED (EDT-a group, n=10); and (3) no doctor dispatched to the scene, and the thoracotomy was performed in the ED (EDT-b group, n=37). The patients in the EFT and EDT-a groups were managed within the Japanese helicopter emergency medical service system with a doctor dispatched to the scene. RESULT: The time between the arrival of the EMT at the scene and the start of the thoracotomy was significantly shorter in the EFT group than in the EDT-b group (19.2+/-7.9 min vs. 30.7+/-6.8 min, p<0.001). In the EFT group, the "ICU admission" rate was significantly higher among the patients who experienced cardiac arrest after the EMT arrival than among the patients who experienced cardiac arrest before the EMT arrival (70% vs. 8%, p=0.001). Unfortunately, however, there were no survivors in this series. CONCLUSION: These findings indicate that "early access" to a doctor's expertise and the performance of an "emergency field thoracotomy" might be two important factors for improving the possibility of saving the lives of blunt trauma patients with impending or recent cardiac arrest.


Subject(s)
Air Ambulances , Cardiopulmonary Resuscitation/methods , Emergency Medical Services/organization & administration , Thoracic Injuries/surgery , Thoracotomy/methods , Wounds, Nonpenetrating/surgery , Adult , Clinical Competence , Female , Follow-Up Studies , Humans , Incidence , Japan/epidemiology , Male , Middle Aged , Retrospective Studies , Thoracic Injuries/epidemiology , Thoracotomy/nursing , Time Factors , Wounds, Nonpenetrating/epidemiology
13.
Ann Vasc Dis ; 2(2): 114-7, 2009.
Article in English | MEDLINE | ID: mdl-23555369

ABSTRACT

A 42-year-old woman complained of a sudden swelling and pain in her left lower extremity. Her lower abdomen was distended, and the thrombosis of iliac vein caused by giant myoma was detected by magnetic resonance imaging. A laparotomy was performed under general anesthesia with positive-pressure ventilation, anterior total hysterectomy and thrombectomy of iliofemoral vein simultaneously were performed. A postoperative venography revealed excellent recanalization of iliofemoral vein and she was subsequently discharged from hospital. Her clinical course has been extremely good, with no symptoms of post-thrombotic syndrome for two years.

14.
ASAIO J ; 54(4): 412-5, 2008.
Article in English | MEDLINE | ID: mdl-18645360

ABSTRACT

Recently, the existence of a relationship was reported between the severity of lung injury and the serum level of F2-isoprostane, a known oxidative stress marker. Recent reports have suggested that direct hemoperfusion with a polymyxin B-immobilized fiber column (DHP-PMX) may improve the oxygenation in patients with acute lung injury and acute respiratory distress syndrome. Because cases of septic shock associated with respiratory diseases have poor outcomes, we selected cases of septic shock associated with respiratory disease to review the characteristics of the treatment-resistant cases. We treated 13 septic shock cases due to respiratory disease using DHP-PMX. The patients were separated into 2 groups for analysis from oxygenation effect immediately after DHP-PMX: A group (7 cases) PaO2/FiO2 ratio increased more than 20%; B group (6 cases) PaO2/FiO2 ratio did not increase more than 20%. Factors were measured before DHP-PMX. The average Acute Physiology and Chronic Health Evaluation II score was 31.2 +/- 9.4, and the average sequential organ failure assessment score was 15.1 +/- 5.3 before DHP-PMX. Four patients survived and 9 died. Only the F2-Isoprostane level was significantly high in B group (p = 0.0228). A relationship between F2-Isoplostane and rebellious cases by DHP-PMX in severe respiratory disease patients became clear.


Subject(s)
Anti-Bacterial Agents/therapeutic use , Hemoperfusion , Oxidative Stress/physiology , Polymyxin B/therapeutic use , Respiratory Distress Syndrome/therapy , Drug Resistance/physiology , F2-Isoprostanes/blood , Female , Hemoperfusion/methods , Humans , Male , Middle Aged , Respiratory Distress Syndrome/blood , Respiratory Distress Syndrome/etiology , Shock, Septic/complications
15.
ASAIO J ; 54(1): 129-32, 2008.
Article in English | MEDLINE | ID: mdl-18204329

ABSTRACT

Septic shock is a condition associated with diffuse coagulopathy and multiple organ failure, and frequently ends in death. Direct hemoperfusion using a polymyxin B-immobilized fiber column (DHP-PMX) was first developed in Japan in 1994 and has since been used for the treatment of septic shock. On the other hand, the effectiveness of continuous hemodiafiltration using a polymethylmethacrylate membrane hemofilter (PMMA- CHDF) for critically ill patients has also been reported. We treated 27 septic shock patients by DHP-PMX. The patients, except for the nine in whom CHDF was not performed after DHP-PMX, were divided into two groups: namely, a group in which PMMA-CHDF therapy was added after DHP-PMX (11 cases), and a group in which continuous hemodiafiltration using a polyacrylonitrile membrane hemofilter (PAN-CHDF) therapy was added after DHP-PMX (7 cases). The outcomes in the two groups were compared. The average Acute Physiology and Chronic Health Evaluation (APACHE) II score and the average sepsis-related organ failure assessment (SOFA) score were not significantly different between the two groups. The PMMA-CHDF group showed significantly better outcomes, with significant improvements of the serum PAI-1, protein C, IL-6 and N-arachidonoylethanolamine (AEA) levels. We conclude that PMMA-CHDF may be more effective than PAN-CHDF in the management of septic shock.


Subject(s)
Hemofiltration/methods , Polymethyl Methacrylate/chemistry , Polymyxin B/chemistry , Shock, Septic/therapy , Acrylic Resins/chemistry , Adult , Aged , Arachidonic Acids/chemistry , Cytokines/metabolism , Endocannabinoids , Female , Humans , Male , Membranes, Artificial , Middle Aged , Polymyxin B/therapeutic use , Polyunsaturated Alkamides/chemistry , Treatment Outcome
16.
J Nippon Med Sch ; 75(6): 337-9, 2008 Dec.
Article in English | MEDLINE | ID: mdl-19155570

ABSTRACT

A 30-year-old man was injured when the large motorcycle he was riding crashed into a power pole. Upon arrival at our institution, the patient complained of abdominal pain; blood pressure at admission was 160/70 mmHg, and the heart rate was 112 bpm. Abdominal ultrasonography showed a small collection of fluid in Morrison's pouch. A chest X-ray film showed a right rib fracture. Multidetector computed tomography (MD-CT) revealed pleural effusion, a hepatic lesion, and a dissection of the abdominal aorta distal to the renal artery. Because of the complicated intraluminal injuries, the insertion of a stent graft was difficult. On the 34th day after injury, elective surgery was performed. Because dissection of the lumen was observed, the vessel was replaced with an artificial graft. Medial degeneration of the aorta wall was not observed upon pathological examination, and no degenerative disorders have occurred. The postoperative progress was favorable, and the patient was discharged from hospital.


Subject(s)
Accidents, Traffic , Aorta, Abdominal/injuries , Adult , Aortic Dissection/etiology , Aorta, Abdominal/surgery , Humans , Male , Wounds, Nonpenetrating
17.
ASAIO J ; 53(5): 646-50, 2007.
Article in English | MEDLINE | ID: mdl-17885340

ABSTRACT

Direct hemoperfusion using a polymyxin B-immobilized fiber column (PMX; Toray Industries Inc., Tokyo, Japan) was first developed in 1994 and has since been used for the treatment of septic shock. Positive clinical data, such as an increase in systolic blood pressure (SBP) and an improved Pao2/Fio2 ratio, have also been reported. We treated 27 septic shock patients using DHP-PMX. The patients were separated into two groups for analysis: those whose Pao2/Fio2 ratio increased after DHP-PMX (9 cases) and those whose Pao2/Fio2 ratio did not increase after DHP-PMX (18 cases). The patients were also separated into two other groups for analysis: those whose SBP increased by more than 30 mm Hg immediately after DHP-PMX (15 cases) and those whose SBP did not increase by more than 30 mm Hg after DHP-PMX (12 cases). The Pao2/Fio2 ratio increased significantly after DHP-PMX in the groups showing improved 2AG and PAI-1 levels (p = 0.0040). The SBP increased significantly in the group showing improved HMGB-1 levels (p < 0.0001). We observed a relationship between hemodynamic improvement and increase of the serum HMGB-1 levels and between improvement of respiratory functions and increase of the serum 2-AG and PAI-1 levels in septic shock patients treated with DHP-PMX.


Subject(s)
Anti-Bacterial Agents/therapeutic use , Arachidonic Acids/blood , Glycerides/blood , HMGB1 Protein/blood , Plasminogen Activator Inhibitor 1/blood , Polymyxin B/therapeutic use , Shock, Septic/therapy , APACHE , Aged , Blood Pressure/drug effects , Endocannabinoids , Enzyme-Linked Immunosorbent Assay , Female , Hemoperfusion/methods , Humans , Interleukin-6/blood , Male , Middle Aged , Polyunsaturated Alkamides/blood , Protein C/analysis , Severity of Illness Index , Shock, Septic/blood , Spectrometry, Mass, Electrospray Ionization , Treatment Outcome
18.
ASAIO J ; 53(3): 324-8, 2007.
Article in English | MEDLINE | ID: mdl-17515723

ABSTRACT

Direct hemoperfusion (DHP) using a polymyxin B (PMX)-immobilized fiber column has been used for treatment of endotoxemia-induced septic shock in Japan since 1994 and is now an accepted therapy for reducing serum endotoxin levels. Although a reduction in inflammatory cytokines has been reported, the detailed mechanism of DHP-PMX is not known. We investigated the high-mobility group box-1 (HMGB-1) level in septic shock patients treated with DHP-PMX. Subjects (n = 20) were separated into two group: those whose systolic blood pressure increased to more than 30 mm Hg immediately after DHP-PMX (effective [E] group: nine cases) and those whose systolic blood pressure did not increase to more than 30 mm Hg (noneffective [N-E] group: 11 cases). The interleukin-6, plasminogen activator inhibitor-1, and HMGB-1 levels were measured in each group. The Pao2/Fio2 ratio and the Sepsis-Related Organ Failure Assessment (SOFA) score were also evaluated. Pretreatment interleukin-6, plasminogen activator inhibitor-1, and HMGB-1 levels were similar in the E and N-E groups, but mortality rate was significantly higher in the N-E group. Furthermore, posttreatment SOFA score was significantly lower in the E group. In the E group, only the HMGB-1 levels improved significantly after DHP-PMX. Present data suggest that the circulation dynamics of septic shock patients can be improved by reducing HMGB-1 levels by using DHP-PMX.


Subject(s)
Anti-Bacterial Agents , HMGB1 Protein/blood , Hemoperfusion/methods , Polymyxin B , Shock, Septic/therapy , Adult , Aged , Aged, 80 and over , Blood Pressure , Endotoxins/blood , Female , Humans , Interleukin-6/blood , Male , Middle Aged , Multiple Organ Failure/blood , Multiple Organ Failure/therapy , Plasminogen Activator Inhibitor 1/blood , Protein C/metabolism , Shock, Septic/blood
19.
Indian J Gastroenterol ; 25(5): 265-6, 2006.
Article in English | MEDLINE | ID: mdl-17090855

ABSTRACT

Superior mesenteric artery (SMA) syndrome is a condition where compression of the duodenum between the root of the SMA and the aorta results in intermittent obstruction of the third part of duodenum. Portal venous gas associated with nonischemic bowel is uncommon. We report an 81-year-old man who developed gastric pneumatosis and hepatoportal venous gas due to SMA syndrome, which healed without any sequelae.


Subject(s)
Duodenal Obstruction/complications , Gastric Dilatation/etiology , Superior Mesenteric Artery Syndrome/complications , Aged, 80 and over , Duodenal Obstruction/diagnostic imaging , Duodenal Obstruction/surgery , Gastric Dilatation/diagnostic imaging , Gastric Dilatation/surgery , Humans , Laparotomy , Male , Portal Vein/diagnostic imaging , Portal Vein/pathology , Superior Mesenteric Artery Syndrome/diagnostic imaging , Superior Mesenteric Artery Syndrome/surgery , Tomography, X-Ray Computed , Treatment Outcome
20.
Isr Med Assoc J ; 8(1): 8-11, 2006 Jan.
Article in English | MEDLINE | ID: mdl-16450743

ABSTRACT

BACKGROUND: In Japan, helicopters have rarely been used for emergency medical services. The use of helicopters not only ensures rapid evacuation but may also serve to provide emergency management to patients with life-threatening injuries in the prehospital setting. OBJECTIVES: To evaluate a Japanese helicopter-based emergency medical system including an onboard physician, particularly in terms of probability of survival. METHODS: We conducted a retrospective review of trauma victims, and calculated two estimates of PS--at the scene and on arrival at the emergency department--based on patient age, Injury Severity Score, and Revised Trauma Score. RESULTS: We identified trauma victims who had an ISS above 15 and were transported from the scene by helicopter. Excluding cardiopulmonary arrest at the scene, 151 cases were studied. Thirty-two patients had hemodynamic instability with systolic blood pressures below 90 mmHg, caused by hemorrhagic shock (29 cases) or obstructive shock (3 cases). Their PS values were 0.56 +/- 0.38 in the prehospital setting and 0.65 +/- 0.38 on arrival at the ED, representing a significant difference (P = 0.0003). Twenty-four of these patients survived, reflecting successful resuscitation during prehospital and ED management. CONCLUSIONS: A doctor-helicopter system was shown to improve probability of survival for life-threatening trauma in the Japanese emergency medical system.


Subject(s)
Air Ambulances/statistics & numerical data , Emergency Medical Services/statistics & numerical data , Wounds and Injuries/therapy , Adolescent , Adult , Aged , Aged, 80 and over , Blood Pressure , Child , Child, Preschool , Evaluation Studies as Topic , Female , Humans , Injury Severity Score , Japan , Male , Middle Aged , Retrospective Studies , Survival Analysis , Treatment Outcome , Wounds and Injuries/classification , Wounds and Injuries/mortality
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