Design of sonochemical assisted synthesis of Zr-MOF/g-C3N4-modified electrode for ultrasensitive detection of antipsychotic drug chlorpromazine from biological samples.

The rapid fabrication is described of binary electrocatalyst based on a highly porous metal-organic framework with zirconium metal core (Zr-MOF) decorated over the graphitic carbon nitride (g-C3N4) nanosheets via facile ultrasonication method. It is used for the robust determination of antipsychotic drug chlorpromazine (CLP) from environmental samples. The electrochemical behaviour of 2D Zr-MOF@g-C3N4 was characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) studies. The crystalline and porous nature of the composite was characterized by XRD and SEM analysis. The functional groups and surface characteristics were investigated by FT-IR, Raman and XPS. The major electrochemical properties of the Zr-MOF@g-C3N4 composite towards CLP detection were analyzed by CV, chronocoulometric (CC), chronoamperometric (CA) and differential pulse voltammetry (DPV) techniques. The composite exhibits a low detection limit (LOD) of 2.45 nM with a linear range of 0.02 to 2.99 µM and attractive sensitivity for CLP. The sensor system shows higher selectivity towards the possible interferences of CLP drug and exhibits better repeatability and stability. Finally, the fabricated sensor system shows a high recovery range varying from 96.2 to 98.9% towards the real samples. The proposed electrochemical probe might be a promising alternative to the prevailing diagnostic tools for the detection of CLP.

Photophysical Behaviour of Novel Quaternary Pyrenoyl Salts and Their Sensitivity Towards Bile Salt Micellization.

The present work describes the synthesis and characterization of pyrene derivatives, N-(1-Pyrenoylmethyl) pyridinium bromide (PM-PB) and N-(1-Pyrenoylmethyl)-N,N,N-triethylammonium bromide (PM-TAB). The photophysical behavior of these molecules has been studied in various protic and aprotic solvents. Using steady state fluorescence intensity, fluorescence anisotropy and dynamic fluorescence lifetime studies, the sensitivity of these molecules towards the micellization process of bile salts has been monitored. These derivatives have been effectively used in estimating critical micellar concentration (CMC) of bile salt, sodium deoxycholate (NaDC).

Green synthesis of silver nanoparticles from plant latex and their antibacterial and photocatalytic studies.

The present work describes a facile synthesis of silver nanoparticles from calotropis procera (CP-AgNPs). The CP-AgNPs were well characterized by many methods. The synthesized CP-AgNPs are stable for more than 5 months. Then we have used CP-AgNPs as photo catalysts for the degradation of methyl orange (MO) dye. The photocatalytic degradation efficiency was 0.0076. Moreover, we also have studied the antibacterial activity against pseudomonas aeruginosa (PA), klebsiella pneumonia (KP), staphylococcus aureus (SA) and bacillus subtilis (BS) bacteria. Interestingly, all four different bacteria causing biofilm were inhibited by CP-AgNPs by 80%. To the best of our knowledge, this is the first report for the synthesis of silver nanoparticles from calotropis procera plant latex. Furthermore, CP-AgNPs effectively were applied as photo catalysts for the degradation of MO dye and also as anti-biofilm agents.

Synthesis, spectroscopic characterization, electrochemical behaviour and antibacterial activity of Ru(III) complexes of 2-[(4-N,N'-dimethylaminophenylimino)-methyl]-4-halophenol.

The reaction of the chelating Schiff base ligands 2-[(4-N,N'-dimethylaminophenylimino)-methyl]-4-X-phenol with [Ru(Cl)(3)(EPh(3))(3)]; (E=P or As); (X=Cl, Br or I) in the benzene afforded new stable ruthenium complexes of the general formula [Ru(Cl)(2)(EPh(3))(2)(L)] (L=anion of bidentate Schiff bases). The newly synthesized complexes were characterized using molar conductivity, spectral (UV-vis, FT-IR and EPR) and electrochemical studies. The molar conductance measurements proved that all these complexes are non-electrolytes. All complexes show strong d-d transition in the visible region. The coordination of imine nitrogen and phenolic oxygen of ligands to ruthenium metal was confirmed with the change in the IR stretching frequency values. The EPR spectral data showed that the complexes are paramagnetic with one unpaired electrons. The redox behaviour of the complexes have been investigated by the cyclic voltammetric technique. All the complexes display an irreversible reduction (Ru(III)/Ru(II)) in the range of -0.826 to -0.971V. In view of the biological activity, the ligands and the complexes were observed that all the complexes showed moderate activity. Also the antibacterial activity of the ligand increased on chelation with metal ion.