ABSTRACT
Non-Hodgkin's Lymphomas (NHL) have been reported in association with autoimmune disorders particularly Sjogren's syndrome. We report a case of renal MALToma, an unusual NHL in an 84-year-old Caucasian lady with long-standing, non-aggressive Systemic Lupus Erythematosis with no associated Sjorgen's syndrome and who never received cytotoxics.
Subject(s)
Kidney Neoplasms/diagnosis , Lupus Erythematosus, Systemic/complications , Lymphoma, B-Cell, Marginal Zone/diagnosis , Aged, 80 and over , Antigens, Differentiation, B-Lymphocyte/metabolism , Antigens, Differentiation, T-Lymphocyte/metabolism , Biomarkers, Tumor/metabolism , Biopsy, Needle/methods , Female , Humans , Immunohistochemistry , Kidney Neoplasms/metabolism , Kidney Neoplasms/pathology , Lupus Erythematosus, Systemic/metabolism , Lymphoma, B-Cell, Marginal Zone/metabolism , Lymphoma, B-Cell, Marginal Zone/pathology , Proto-Oncogene Proteins c-bcl-2/metabolism , Proto-Oncogene Proteins c-bcl-6/metabolism , Tomography, X-Ray ComputedSubject(s)
Arthritis, Rheumatoid/pathology , Fever of Unknown Origin/pathology , Pancytopenia/pathology , Vasculitis/pathology , Arthritis, Rheumatoid/complications , Arthritis, Rheumatoid/immunology , Blood Cell Count , Bone Marrow/pathology , Fatal Outcome , Fever of Unknown Origin/complications , Fever of Unknown Origin/immunology , Humans , Immunohistochemistry/methods , Male , Middle Aged , Necrosis , Pancytopenia/complications , Pancytopenia/immunology , Platelet Count , Skin/pathology , Vasculitis/complications , Vasculitis/immunologyABSTRACT
Wegener's granulomatosis (WG) and sarcoidosis are two distinct granulomatous diseases characterized by multisystem involvement. We report a patient who initially presented with symptoms of limited WG predominantly affecting the nose, followed by a facial rash, which was histologically proven to be due to sarcoidosis. The sequential development of these two diseases in one patient is very rare, and to our knowledge, only one such case has been reported in the last 50 years (Am J Kidney Dis 28:893-898, 1996).
