ABSTRACT
Experiments were performed in 9 dogs and 20 rats. The effect of heparin (3-4 mg/kg of the body weight) on the lung surfactant was studied under conditions of bacterial endotoxic shock. Heparin was found to decrease the surfactant content in lungs by 57.6% in intact animals, while under conditions of endotoxic shock by 92.2% as compared with the initial level.
Subject(s)
Heparin/adverse effects , Pulmonary Surfactants/antagonists & inhibitors , Shock, Septic/therapy , Animals , Dogs , Endotoxins , Hemoperfusion/methods , Heparin/administration & dosage , Pulmonary Surfactants/biosynthesis , Rats , Respiratory Insufficiency/chemically induced , Shigella sonnei , Shock, Septic/etiologyABSTRACT
The experiments were carried out in 27 dogs with endotoxic shock under conditions of the artificial ventilation of the lungs and barbital anesthesia. It was established that under the above conditions the metabolic functions of the lungs were the first to be impaired. The artificial ventilation of the lungs fails to prevent the development of the impairment of the surfactant-synthesizing function of the lungs as well as the serotonin-inactivating function of the lungs. Two stages of the development of the shock lung syndrome were distinguished: the first one is the disturbance of the metabolic functions of the lungs; the second one is the disturbance of the gas exchange function of the lungs.
