ABSTRACT
The nutritive status features and the main parameters of nitrogen metabolism were investigated in 212 children with acute leukemia at varying stages of the disease. A study was made of the patients' body mass, nitrogen balance, excretion of nitrogenous compounds with urine and feces, total protein and albumin content in the blood, as well as blood content of urea, creatinine, amino nitrogen and uric acid. The results of the study have shown a negative influence of both leukemia and its therapy on the nutritive status of the patients, that was manifested in protein-energy deficiency and in protein assimilation disorders. A relationship has been revealed between infectious complications, preventing the successful treatment, and the nutritive status of the patients. Clarification of these pathogenetic mechanisms of the negative action of the disease itself and antileukemic therapy will help in the realization of the purposeful correction.
Subject(s)
Dietary Proteins/metabolism , Leukemia/metabolism , Nutritional Status , Acute Disease , Adolescent , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Body Weight/drug effects , Child , Dietary Proteins/drug effects , Female , Humans , Leukemia/drug therapy , Male , Nitrogen/urine , Nutritional Status/drug effects , Remission Induction , Time FactorsSubject(s)
Homeostasis , Leukemia/therapy , Acute Disease , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Child , Combined Modality Therapy , Humans , Leukemia/drug therapy , Leukemia/physiopathology , Remission InductionABSTRACT
A study was made of the content of ubiquinone, vitamins A, E, ascorbic, dehydroascorbic and diketogulonic acids (DKGA), and malonic dialdehyde (MDA) in the liver, of the content of glutathione, the activity of superoxide dismutase (SOD) and glutathione reductase in red blood cells, of the content of vitamins A, E and ubiquinone in the spleen of C57Bl/6jG mice with inoculated leukemia La. It was found that in red blood cells of the animals with leukemia, the content of vitamin E and DKGA reduced, the MDA level increased, and the content of glutathione dropped whereas SOD activity rose. Application of the antioxidant complex of vitamins A, E, C appreciably improved the characteristics of enzymatic and non-enzymatic antioxidant protection of the liver and red blood cells of the leukemic animals without exerting any noticeable effect on the content of vitamin E and ubiquinone in the leukemic spleen tissue.
