ABSTRACT
Cases of sepsis with bacteriemia detected in the S. P. Botkin State Clinical Hospital within 2000-2007 were analysed. The sources of the bacteriemia, the etiological pattern of the pathogens and their susceptibility to antibacterials were estimated. The study enrolled 256 patients with sepsis. The antibiotic susceptibility of 227 isolates from the blood samples was tested. More than a half of the infection sources was detected in the organs of the respiratory tract and abdominal cavity. All the grampositive pathogens were susceptible to vancomycin and linesolid. The overwhelming majority of the enterococcal isolates proved to be susceptible to carbapenem and cefepim.
Subject(s)
Acetamides/pharmacology , Anti-Bacterial Agents/pharmacology , Carbapenems/pharmacology , Cephalosporins/pharmacology , Gram-Negative Bacterial Infections , Gram-Positive Bacterial Infections , Oxazolidinones/pharmacology , Sepsis/etiology , Vancomycin/pharmacology , Acetamides/therapeutic use , Adolescent , Adult , Aged , Aged, 80 and over , Anti-Bacterial Agents/therapeutic use , Carbapenems/therapeutic use , Cefepime , Cephalosporins/therapeutic use , Drug Resistance, Microbial , Enterobacteriaceae/drug effects , Enterobacteriaceae/isolation & purification , Female , Gram-Negative Bacterial Infections/blood , Gram-Negative Bacterial Infections/complications , Gram-Negative Bacterial Infections/microbiology , Gram-Positive Bacteria/drug effects , Gram-Positive Bacteria/isolation & purification , Gram-Positive Bacterial Infections/blood , Gram-Positive Bacterial Infections/complications , Gram-Positive Bacterial Infections/microbiology , Hospitals/statistics & numerical data , Humans , Linezolid , Male , Microbial Sensitivity Tests , Middle Aged , Oxazolidinones/therapeutic use , Retrospective Studies , Russia/epidemiology , Sepsis/drug therapy , Vancomycin/therapeutic useABSTRACT
Simultaneous determination of aldolase fructose-1-phosphate activity in the liver and blood plasma of experimental rats gives possibility to judge of histohaematic permeability of liver barriers. The presence and advancement of the pathological process in liver is characterized by acid maltase activity. Normalization of histohaematic barrier permeability is observed after ultrasonic action of 0.2 wt/cm2 intensity on the liver area in experimentally induced immunological hepatitis.