ABSTRACT
In experiments on sodium pentobarbital (40 mg/kg, i.p.) anesthetized mongrel cats of either sex weighting from 2.0 to 4.0 kg, it was found, that in conditions of oil pulmonary microembolization, followed by pulmonary edema, the most suitable is rapid and shallow pattern of ventilation, ensuring optimal ventilation/perfusion interrelation. The oil microembolization was introduced with intravenous administration (1 mg per kg of body weight during 2 min) of olive oil. It is necessary to provide flexible regimens of artificial ventilation and conformity of respiratory pattern and body's demands can be controlled according to pHa and PaO2. It is desirable that pH and pO2 can be evaluated continuously.
Subject(s)
Embolism, Fat/therapy , Pulmonary Edema/therapy , Pulmonary Embolism/therapy , Respiration, Artificial , Animals , Cats , Embolism, Fat/complications , Embolism, Fat/physiopathology , Female , Hydrogen-Ion Concentration , Male , Oxygen/blood , Pulmonary Edema/etiology , Pulmonary Edema/physiopathology , Pulmonary Embolism/complications , Pulmonary Embolism/physiopathology , Respiration , Respiratory Function TestsSubject(s)
Bronchi/blood supply , Pulmonary Circulation/drug effects , Thyrotropin-Releasing Hormone/administration & dosage , Administration, Intranasal , Animals , Bronchi/drug effects , Cats , Dose-Response Relationship, Drug , Female , Hemodynamics/drug effects , Hemodynamics/physiology , Injections, Intravenous , Male , Pulmonary Circulation/physiology , Regional Blood Flow/drug effects , Time FactorsABSTRACT
The effect of TRH and its synthetic analogue (PR-546) devoid of hormonal activity was studied in acute experiments on rats on the model of neurogenic lung edema caused by skull injury. It was proved that the preliminary (for 30 min before the injury) i/p introduction of TRH (in doses 0.5-1 mg/kg) and PR-546 (in doses 4-8 mg/kg) prevented the development of acute edema and the changes of blood gas compositions as well as disorders in breathing after skull injury. It was assumed that the protective effect of studied peptides is possibly achieved through the intensification of breathing and cardiovascular centers activity.