ABSTRACT
The present study was motivated by the lack of data on the role ofvariations in the levels of leptin and its soluble receptors and their interaction with proinflammatory factors in the development of acute coronary syndrome. The study included patients suffering myocardial infarction with and without type 2 diabetes mellitus. Hyperleptinemia and its relationship with myocardial necrosis markers (creatine phosphokinase, creatine phosphokinase-MB, troponin) give reason to suggest the important role of leptin in the development of inflammatory process associated with myocardial infarction in patients with and without diabetes mellitus. The results of the study provide a basis for the elaboration of a new therapeutic strategy for the correction of metabolic disorders in patients with acute coronary syndrome.
Subject(s)
Diabetes Mellitus, Type 2/blood , Diabetes Mellitus, Type 2/immunology , Leptin/blood , Myocardial Infarction/blood , Myocardial Infarction/immunology , Receptors, Leptin/blood , Aged , Female , Humans , Male , Middle AgedABSTRACT
AIM: Summarization of the results of family studies of inherited predisposition to myocardial infarction (MI) in young subjects from families with antigen Cw4 in phenotype. MATERIALS AND METHODS: Young probands (32, 37 and 46 years of age) with MI and the family members were examined. RESULTS: Antigen Cw4 predicts MI in young males living in the city of Kazan with MI hereditary load. CONCLUSION: The findings enable localization of at least one gene involved in development of hereditary predisposition to MI in the group of HLA link on the short arm of human chromosome 6.
