ABSTRACT
The authors share their experiences with diagnosing and surgical treatment of chronic postoperative osteomyelitis of sternum developed in 36 patients after operations on the heart, lungs and organs of mediastinum. The purulent process can be liquidated in all the patients due to performing saving resection of the sternum and plasty of the bone defect with local tissues, application of a gauze-cotton roll pressing the subcutaneous fat into the bone defects formed after treatment of the affected portions of the sternum, administration of antibiotics according to sensitivity of the microflora.
Subject(s)
Osteomyelitis/surgery , Postoperative Complications/surgery , Sternum/surgery , Thoracic Diseases/surgery , Thoracic Surgical Procedures/methods , Adult , Aged , Cartilage/surgery , Chronic Disease , Female , Humans , Male , Middle Aged , Osteomyelitis/microbiology , Postoperative Care/methods , Postoperative Complications/microbiology , Ribs/surgery , Sternum/microbiology , Suture Techniques , Thoracic Diseases/microbiologyABSTRACT
DNA level measured by flow cytometry and estrogen and progesterone receptors assayed in tissue samples obtained from 85 malignant and 16 benign lesions of the breast. All the benign tumors revealed 2c DNA content and most of them were receptor-negative, while 74.1% of breast carcinomas displayed aneuploidy. Three patients (3.5%) had two lines of aneuploid cells. Many aneuploid tumors were receptor-negative. Preoperative radiation treatment (14-20 Gy) did not significantly influence the level of steroid hormone receptors in tumors. Estrogen receptor level was higher in menopausal patients than in premenopausal ones.
Subject(s)
Breast Neoplasms/analysis , DNA, Neoplasm/analysis , Receptors, Estrogen/analysis , Receptors, Progesterone/analysis , Adult , Aged , Aneuploidy , Breast Neoplasms/genetics , DNA, Neoplasm/genetics , Diploidy , Female , Flow Cytometry , Humans , Menopause , Middle AgedABSTRACT
The content of estrogen (ER) and progesteron receptors (PR) were studied as related to histological type, the degree of malignancy and growth rate of spontaneous canine mammary carcinomas. No correlation was found between the ER and PR amount, histological type and degree of malignancy. Inverse correlation was detected between ER and PR and the growth rate. These results correspond to those obtained for human mammary tumours. Therefore canine mammary carcinomas can be considered as an adequate model for experimental therapy of this type of tumours.
