ABSTRACT
The aim of this work was to study colonic microbiocenosis, endotoxin level, intensity of systemic inflammation and the state of matrix metalloproteinase (MMP) system and MMP tissue inhibitors (TIMP) in 75 patients with post-infarction cardiosclerosis at different stages of chronic cardiac failure (CCF). The patients were examined by clinical, echocardiographic and laboratory methods including bacteriological analysis of feces and measurement of amino-terminal brain natriuruetic peptide, endotoxin, TNF-alpha, MMP-9, and TIMP-4. The progress of CCF was shown to be associated with increasing colonic dysbiosis, endotoxin and TNF-alpha levels, disbalance in the MMO and TIMP systems.
Subject(s)
Colon/microbiology , Colon/pathology , Heart Failure/microbiology , Heart Failure/pathology , Inflammation Mediators/physiology , Chronic Disease , Colon/enzymology , Comorbidity , Cytokines/blood , Endotoxins/blood , Female , Heart Failure/enzymology , Humans , Inflammation Mediators/blood , Inflammation Mediators/metabolism , Male , Matrix Metalloproteinase 9/blood , Middle Aged , Severity of Illness Index , Tissue Inhibitor of Metalloproteinases/blood , Tumor Necrosis Factor-alpha/bloodABSTRACT
The article discusses the results of detection of activity of matrix metalloproteinase-9, tissue inhibitors of metalloproteinases-4, endotoxin, tumor necrosis factor-alpha, C-reactive protein, sE-selectine in blood of patients with chronic cardiac failure depending on severity of disease. It is demonstrated that progressing of chronic cardiac failure is associated with the increase of level of endotoxemia, activation of systemic inflammation and misbalance in the system of matrix metalloproteinase and tissue inhibitors of metalloproteinase.
Subject(s)
Chronic Disease , Endotoxins/blood , Heart Failure/blood , Inflammation/blood , C-Reactive Protein/analysis , Female , Humans , Male , Matrix Metalloproteinase 9/blood , Middle Aged , Natriuretic Peptide, Brain/blood , Peptide Fragments/blood , Tissue Inhibitor of Metalloproteinases/blood , Tumor Necrosis Factor-alpha/blood , Tissue Inhibitor of Metalloproteinase-4ABSTRACT
AIM: To study trends in systemic inflammatory factors and aminoterminal brain natriuretic propeptide (NT-proBNP) in the blood of patients with stage IIA and IIB chronic heart failure (CHF) during therapy aimed at reducing venous congestion. MATERIAL AND METHODS: The study enrolled 52 patients with postinfarction cardiosclerosis (PICS). Clinical, echocardiographic and laboratory studies were conducted. The levels of TNF-alpha, IL-6, IL-10 and C-reactive protein (CRP) were measured by enzyme immunoassay. The concentration of endotoxin (ET) was estimated by the end-point chromogenic LAL test, that of NT-proBNP--by immunochromotographic assay. RESULTS: In the patients with CHF, clinical signs of pulmonary venous congestion are associated with a statistically significant increase in the blood levels of TNF-alpha and CRP, those of systemic venous congestion are related to a further rise in TNF-alpha levels and elevation of blood concentrations of NT-proBNP, ET and IL-10. Treatment-related reduction in pulmonary venous congection is associated with a decrease in the levels of TNF-alpha, CRP and IL-6; that in systemic venous congestion--with lower concentrations of NT-proBNP, TNF-alpha and ET. CONCLUSION: Specific changes in the levels of systemic inflammatory factors and NT-proBNP were found in patients with CHF in the presence of pulmonary and systemic venous congestion. Treatment aimed at elimination of the latter leads to reduction in the levels of systemic inflammatory factors and NT-proBNP.
