ABSTRACT
A study was made of 73 Wisconsin cases of canine blastomycosis. Each case was studied with respect to the life history of the animal. It was considered that a large percentage of the dogs were infected while in Wisconsin, since 40 had never left the state, and it was highly probable that in a large percentage of the other 33 cases the disease was contracted while the dog resided in Wisconsin. A study of the cases with respect to county of residence, birth and visitation revealed that there were three regions in the state where blastomycosis was prevalent: one region in the southeast and two regions in the northern parts of the state. An increase in the number of canine cases of blastomycosis over the years was considered to result from an increase in the skill of the veterinarian in diagnosing the disease. It was thought that a similar increase in number of human cases reported in recent years resulted from improvements in isolation techniques. The number of canine cases, 75, and human cases, 182, published up to now were considered to be minimum figures since many cases remain unpublished. A study of contiguous human and canine cases of blastomycosis lent support to the hypothesis that Ajellomyces (Blastomyces) dermatitidis conidia may be disseminated in fog or mist. Two cases of feline blastomycosis diagnosed in Wisconsin are reported for the first time. One cat acquired the disease in the state: the origin of the infection of the second cat was equivocal since it spent its summers in Wisconsin and its winters in another endemic state.
Subject(s)
Blastomycosis/epidemiology , Cat Diseases/epidemiology , Dog Diseases/epidemiology , Animals , Blastomycosis/transmission , Blastomycosis/veterinary , Cats , Dogs , Humans , Time Factors , WisconsinABSTRACT
Evidence for dehydrogenation by fecal bacteria in the genesis of colon cancer suggested that an antioxidant might modify these mechanisms. Ascorbic acid, 3 Gm. daily, was given to five patients who had active rectal adenomatous polyp formation long after ileorectal anastomosis for familial polyposis. During a 4 to 13 month study, rectal polyps disappeared in two, regressed partially in two, and increased in one. Among three additional treated patients with rectal polyps, one had a reduction in polyps and two were unaffected.
Subject(s)
Ascorbic Acid/therapeutic use , Intestinal Polyps/drug therapy , Rectal Neoplasms/drug therapy , Adolescent , Adult , Antioxidants , Colectomy , Drug Evaluation , Female , Humans , Intestinal Polyps/genetics , Male , Rectal Neoplasms/genetics , Remission, SpontaneousABSTRACT
Improved cellular collection method and cytologic criteria for diagnosis of Paget's disease of the breast are presented. When indicated, the cytologic test is highly recommended for the early detection and pre-operative diagnosis of the minimal breast cancer10.
Subject(s)
Carcinoma, Intraductal, Noninfiltrating/diagnosis , Paget's Disease, Mammary/diagnosis , Specimen Handling/methods , Aged , Cytodiagnosis , Diagnosis, Differential , Evaluation Studies as Topic , Female , Histological Techniques , Humans , Mastectomy , Nipples/pathology , Paget's Disease, Mammary/pathology , Paget's Disease, Mammary/surgeryABSTRACT
A murine mammary tumor was cultured in vitro for 14 days, either in direct combination with various embryonic murine inductive tissues or separated by a Millipore filter from these tissues. From 456 test cultures and 269 control cultures of tumor alone, morphologic, histochemical, and autoradiographic evidence for cytodifferentiation was obtained in the tumor after exposure to inductive tissues directly or through the filter. There appeared to be a gradient in potency of the inductive tissues; embryonic mammary mesenchyme was the most active of the tissues tested. Tumor growth was not different from that of controls, however, when the cultured, inductive tissue-exposed neoplasm was returned to the murine host.
Subject(s)
Adenocarcinoma/pathology , Cell Transformation, Neoplastic , Germ Layers , Mammary Neoplasms, Experimental/pathology , Animals , Brain , Cell Division , Culture Techniques , Mammary Glands, Animal , Mice , Mice, Inbred C57BL , Micropore FiltersABSTRACT
A mouse mammary tumor, adenocarcinoma BW 10232, was maintained in vitro for 14 days, separated from embryonic mammary mesenchyme by a Millipore filter. Tubules developed in the tumor; deoxyibonucleic acid synthisis declined; and a presumptive acid mucopolysaccharide matrix, not evident in the controls, appeared.
