Spectroscopic and electrochemical analysis of psychotropic drugs.

Psychotropic drugs are an important family of compounds from a medical point of view. Their application in therapy requires methods for the determination in pharmaceutical dosage forms and body fluids. Several methods for their analysis have been reported in the literature. Among the methods, spectrophotometric and electrochemical are very useful for the determination of the drugs. Some of the spectrophotometric methods are based on the formation of the binary and ternary compounds with complexes of metals. The formed compounds are sparingly soluble in water, but quantitatively extracted from aqueous phase into organic solvents and the extracts are intensely colored and stable for a few days. These complexes have been employed in pharmaceutical analysis. The electrochemical procedures are very useful in determination of the psychotropic substances in pharmaceutical preparations.

Application of reinecke salt and alizarin S for the determination of promazine.

Reinecke salt and alizarin S have been tested as reagents for the determination of promazine. They react in neutral and acidic media with promazine forming a reddish and brown crystalline compounds. The compounds are sparingly soluble in water but fairly soluble in acetone and methanol. The quantitative extraction of compound of promazine with alizarin S has been used for the extractive spectrophotometric determination of promazine. Formation of promazine ion-association complex with Reinecke salt has been applied for indirect determination of low concentrations of promazine by AAS measurement of the chromium content of the reineckate counter - anion.

Examination of iron (III) and hexacyanoferrate (III) ions as reagents for the spectrophotometric determination of promazine and perazine.

Iron (III) chloride and potassium hexacyanoferrate (III) have been tested as reagents for the determination of promazine hydrochloride and perazine. The methods are based on the oxidation of phenothiazines by FeCl3 and K3[Fe(CN)6] in perchloric acid medium. The optimal conditions for the formation of oxidation products of promazine and perazine were examined. The absorption spectra in the UV-VIS region were recorded.