ABSTRACT
Correlation between a degree of activation of hormonal secretion and the expression of a pathological process in the gastroduodenal area was established in patients with peptic ulcer, chronic gastroduodenitis with raised secretory gastric function and in patients after vagotomy. A sequence of involvement in the reaction to disease of the regulatory systems of the local (gastrin, serotonin and histamine mechanisms), systemic (enteroinsular axis) and organic (glucocorticoid and adrenal function of the adrenal glands) levels was revealed.
Subject(s)
Duodenal Ulcer/physiopathology , Duodenitis/physiopathology , Endocrine Glands/metabolism , Gastritis/physiopathology , Adrenal Cortex/metabolism , Chronic Disease , Duodenal Ulcer/blood , Duodenal Ulcer/surgery , Duodenitis/blood , Gastric Mucosa/metabolism , Gastritis/blood , Humans , Islets of Langerhans/metabolism , Postoperative Period , Recurrence , Remission InductionABSTRACT
The level of gastrin, serotonin, insulin and cortisol in the blood was raised after different types of vagotomy. Raised hormone secretion depends on the time following operation, the severity of a pathological process, to a lesser degree, on the type of surgical intervention and nature of postvagotomic disturbance. Shifts in the hormonal apparatus are caused by operation and associated with it functional-morphological changes of the digestive organs, the preservation of preoperative changes and developing compensatory-adaptive reactions. An excess of intestinal hormone secretion in the postoperative period can be responsible for the development of pathological disorders, in particular the dumping syndrome.
Subject(s)
Duodenal Ulcer/surgery , Gastrointestinal Hormones/metabolism , Vagotomy , Adult , Duodenal Ulcer/physiopathology , Female , Humans , Hydrocortisone/metabolism , Insulin/metabolism , Insulin Secretion , Male , Middle Aged , Postoperative Period , Serotonin/metabolismSubject(s)
Endocrine Glands/drug effects , Mineral Waters , Animals , Digestive System/drug effects , Digestive System/metabolism , Duodenal Ulcer/physiopathology , Duodenal Ulcer/therapy , Endocrine Glands/metabolism , Health Resorts , Humans , Pancreas/drug effects , Pancreas/metabolism , Rats , Time Factors , USSRSubject(s)
Adrenal Cortex Hormones/metabolism , Health Resorts , Insulin/blood , Scleroderma, Localized/metabolism , Scleroderma, Systemic/metabolism , Adolescent , Catecholamines/urine , Child , Chronic Disease , Combined Modality Therapy , Humans , Russia , Scleroderma, Localized/therapy , Scleroderma, Systemic/therapy , Time FactorsSubject(s)
Aldosterone/blood , Asthma/therapy , Health Resorts , Hydrocortisone/blood , Insulin/blood , Adolescent , Child , Humans , RussiaABSTRACT
It has been demonstrated that the basal gastrin level in the blood of patients with peptic ulcer of the duodenum is similar to that in normal subjects. Food stimulation raises blood gastrin in normal subjects and patients. However, in patients, the peak of the blood hormone rise is higher, with this rise lasting for a longer time. Besides, the total output of the hormone is greater. These changes are most marked during an incomplete disease remission, being less remarkable when exacerbation gets attenuated and during a complete remission. A correlation has been noticed between the acid-forming function of the stomach and basal blood gastrin level that increases as the acid content in gastric juice descends. In patients experiencing a complete remission and in those in the stage of an incomplete remission and attenuated exacerbation, a direct correlation was ascertained between the stimulated hypergastrinemia and duration of the intragastral pH elevation in response to food intake. It is suggested that in peptic ulcer of the duodenum, hypergastrinemia occurs as a defence reaction aimed at the activation of trophic processes in the mucous membrane of the gastroduodenal zone.
