ABSTRACT
Incidence of lung cancer associated with secondary paracancerous changes is known to range 13.7-30%. Since they reveal such clinical symptoms as pneumonia or empyema, most out-patients with complicated cancers are referred to general wards. Inflammatory parenchymal pathology may be conducive to false-positive or -negative diagnosis even when highly-sophisticated radiation procedures are used.
Subject(s)
Lung Neoplasms/diagnosis , Lung Neoplasms/therapy , Precancerous Conditions/complications , Thoracic Cavity , Thoracic Neoplasms/complications , Aged , Diagnosis, Differential , Empyema/etiology , False Negative Reactions , False Positive Reactions , Female , Humans , Lung Neoplasms/complications , Male , Middle Aged , Pneumonia/etiologyABSTRACT
An experience with diagnostics and surgical treatment of 291 patients with complicated course of lung cancer is described with special reference to specificities of the clinical course, preoperative management and operation technique. It was shown that the purposeful preoperative management allowed the assessment of the patients, previously thought to be inoperable, to be revised in 25% of cases, and the frequency of postoperative complications and lethality to be reduced to 14 and 3.5% respectively. The 5 year survival of lung cancer patients with paracancrous alterations was 20.7%.
Subject(s)
Carcinoma, Non-Small-Cell Lung/pathology , Carcinoma, Non-Small-Cell Lung/surgery , Lung Neoplasms/pathology , Lung Neoplasms/surgery , Paraneoplastic Syndromes/pathology , Streptococcal Infections/pathology , Thoracic Neoplasms/pathology , Carcinoma, Non-Small-Cell Lung/epidemiology , Humans , Lung Neoplasms/epidemiology , Neoplasm Staging , Paraneoplastic Syndromes/epidemiology , Postoperative Complications/mortality , Streptococcal Infections/chemically induced , Streptococcal Infections/epidemiology , Thoracic Neoplasms/epidemiologyABSTRACT
The work presents an experience with the diagnosing of synchronous tumors of double localization in 256 patients. Operations were performed on 146 of them. Single-stage operations were made in 55 cases. When performing single-stage operations, 20 patients were found to have cancer of the lung with distant metastases or cancer of other localization with a metastasis in the lung. In the other 35 patients the diagnosis of true polyneoplasia was made followed by radical operations. Advantages of single-stage operations are shown, performing the first stage of the operation on the lung being substantiated. The five year survival after surgical treatment of multiple primary cancer was 15%.
Subject(s)
Brain Neoplasms/surgery , Digestive System Surgical Procedures/methods , Gastrointestinal Neoplasms/surgery , Lung Neoplasms/secondary , Neoplasms, Multiple Primary/surgery , Neurosurgical Procedures/methods , Pneumonectomy/methods , Adult , Aged , Biopsy , Brain Neoplasms/pathology , Diagnosis, Differential , Female , Follow-Up Studies , Gastrointestinal Neoplasms/pathology , Humans , Laparoscopy , Lung Neoplasms/surgery , Male , Middle Aged , Neoplasms, Multiple Primary/pathology , Retrospective Studies , Thoracoscopy , Treatment OutcomeABSTRACT
The results of the work showed the importance of developing methods for the prevention of ischemic damage to the bronchi and optimal methods for reinforcement of the bronchial suture in lung transplantation. Ischemia may be an important pathogenetic factor of incompetence of the bronchial suture in lung transplantation and may also facilitate disturbance of the transplant's mucociliary clearance with the development of postoperative atelectases, dystelectases, and bronchopneumonia. These data are based on the results of experiments obtained in mongrel dogs by electron microscopy. Prolonged ischemia of the lung (120-180 min) led to mass death of cells of the bronchial endothelium, their rejection from the basement membrane, and desquamation into the bronchial lumen.
