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9.
Vopr Virusol ; (5): 591-7, 1977.
Article in Russian | MEDLINE | ID: mdl-201102

ABSTRACT

The results of the study of reproduction, morphogenesis, and immunogenic properties of Aujeszky's disease virus (ADV) cultivated on an industrial scale in chick, duck and quail embryo explant suspensions are presented. A method for production of vaccine and virulent ADV strains with the activity of at least 7.5 log TCD50/ML in tanks of 5, 50, and 100 1 capacity was developed. A relationship between virion morphology and duration of cultivation was established. For ADV cultivated for 70 hours, a direct relationship between infectivity and immunogenicity was demonstrated.


Subject(s)
Culture Media , Herpesviridae/physiology , Herpesvirus 1, Suid/physiology , Animals , Chick Embryo , Culture Techniques , Dose-Response Relationship, Immunologic , Ducks , Herpesvirus 1, Suid/immunology , Morphogenesis , Quail , Suspensions , Time Factors , Viral Vaccines/isolation & purification , Virus Replication
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