1.
Anticancer Res
; 10(2A): 433-6, 1990.
Article
in English
| MEDLINE
| ID: mdl-2161201
ABSTRACT
We have studied the effect of retinoids, forskolin and TNF-alpha on two sublines of U937 cells, U937/clone 4 and U937/GTB. Retinoids induced differentiation of U937/clone 4, while the U937/GTB cells were resistant to induction of differentiation by retinoids. Retinoids effectively reduced the proliferation of both U937/clone 4 and U937/GTB, and decreased the steady state levels of c-myc mRNA in both sublines. Furthermore, the retinoid resistant U937/GTB cells were hypersensitive to the cytotoxic effect of TNF-alpha. Forskolin increased the cAMP level in the U937/clone 4 cells 14 times above basal level, but did not change the cAMP concentration in the U937/GTB cells.
Subject(s)
Cyclic AMP/biosynthesis , Leukemia, Myeloid/pathology , Tumor Necrosis Factor-alpha/pharmacology , Cell Differentiation/drug effects , Cell Division/drug effects , Cell Line , Colforsin/pharmacology , Drug Resistance , Leukemia, Myeloid/metabolism , Oncogenes , RNA, Messenger/metabolism , Tretinoin/pharmacology , Vitamin A/pharmacology
2.
Geriatrics
; 21(8): 164-79, 1966 Aug.
Article
in English
| MEDLINE
| ID: mdl-5946408
