ABSTRACT
In order to assess the real significance of some plasma and vascular indices in disorders of the stable course of coronary heart disease (CHD) in chronic bacterial- and viral infection-invasion, we determined the blood plasma lipid hydrogen peroxide (LHP) activity, a direct index of the lipid peroxidation degree, and measured the concentration of specific antibodies to Chlamydia pneumoniae (C. pneunoniae), herpes simplex virus type 1 (HSV-1), cytomegalovirus (CMV) and Epstein-Barr virus (EBV) by means of the enzyme-linked immunosorbent assay (ELISA). We examined a total of 70 patients presenting with CHD combined with a concomitant infection both with a stable course of the disease (Group One) and acute coronary syndrome (Group Two), as well as 50 infected people without verified signs of coronary atherosclerosis (Group Three). The comparison group consisted of patients with CHD, being seronegative for the causative agents referred to above. The condition of the major vessels was appropriately assessed by means of duplex ultrasonography (DU). Resulting from the findings of the carried out investigation, we singled out a triad of symptoms characteristic of the transformation of the chronic infectious process into the recurrent phase, which for the CHD patients with the presence of the conventional risk factors of atherosclerosis might become a cause of the disordered stable course of the disease and development of acute ischaemic attacks. The revealed alterations seemed to have been based upon an infectious-origin inflammatory lesion of the vessels, which was duly confirmed by duplex ultrasonography.
Subject(s)
Coronary Artery Disease/microbiology , Vasculitis/microbiology , Adult , Aged , Chlamydia Infections/microbiology , Chronic Disease , Coronary Artery Disease/diagnostic imaging , Coronary Artery Disease/virology , Cytomegalovirus Infections/virology , Echocardiography, Doppler , Enzyme-Linked Immunosorbent Assay , Epstein-Barr Virus Infections/virology , Female , Herpes Simplex/virology , Herpesvirus 1, Human/isolation & purification , Humans , Lipid Peroxidation/physiology , Male , Middle Aged , Risk Factors , Vasculitis/diagnostic imaging , Vasculitis/virologyABSTRACT
A relationship between the emergence of ventricular arrhythmias and other signs of myocardial ischemia was assessed in 96 coronary patients on the basis of comparative results of the physical and psychoemotional stressful tests, and the nitroglycerin and aspirin tests. Ventricular rhythm disorders may develop in the course of mental exercise in some coronary patients with low hemodynamic values as the only manifestation of myocardial ischemia. Large-scale use of the mental stressful test is advocated for cardiologic medical institutions.
Subject(s)
Arrhythmias, Cardiac/diagnosis , Coronary Disease/diagnosis , Stress, Physiological/psychology , Stress, Psychological/psychology , Adult , Arrhythmias, Cardiac/etiology , Arrhythmias, Cardiac/psychology , Aspirin , Coronary Disease/complications , Coronary Disease/etiology , Coronary Disease/psychology , Diagnosis, Computer-Assisted , Electrocardiography , Exercise Test , Hemodynamics , Humans , Male , Middle Aged , Nitroglycerin , PsychophysiologyABSTRACT
Reactions of heart ectopic activity in psychological exercise were similar to those in bicycle ergometry, but the values of pulse and arterial pressure increase were lower. The advantages of the psychological exercise test in detecting disorders of cardiac rhythm in patients, particularly in those hypersensitive to psychogenic effects, is noted. The importance of using psychological exercises in patients with high tolerance to physical exercises, by means of which latent forms of arrhythmias cannot always be detected, is pointed out.
Subject(s)
Coronary Disease/diagnosis , Exercise Test , Psychological Tests , Adult , Angina Pectoris/diagnosis , Blood Pressure , Coronary Disease/psychology , Heart Rate , Humans , Male , Middle AgedABSTRACT
Mental and emotional load consisting of several psychological tests was used in 35 patients with ischemic heart disease to disclose hazardous and latent forms of disorders of cardiac rhythm as possible forewarning of sudden death and to study the role of the psychological factor and stress situation in their origin. The reaction of extopic myocardial activity to the load proved different. In distinction to patients with functional cardiovascular disorders, patients with organic affections of the myocardium responded to the load by the appearance of extrasystoles during the load or by their greated frequency. In patients with functional cardiovascular disorders there was mostly a decrease in the number of initial extrasystoles and in some cases their total disappearance.
